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Referencia número: HY-N21574

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Milliamine D

Milliamine D is a diterpenoid toxin of the ingenol ester class containing an anthraniloyl tripeptide, existing in the free base form and exhibiting molluscicidal activity. Milliamine D can be used in the study of schistosomiasis.

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No. CAS: 88524-59-8
Fòrmula: C₄₅H₄₉N₃O₁₀
Peso molecular:791.88

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Milliamine D Chemical Structure

No. CAS: 88524-59-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

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In Vitro

Milliamine D (compound 7) (100 μg/L; 24 h) kills 100% of Biomphalaria glabrata snails^[2].
Milliamine D is a 5,20-diester of ingenol, featuring an anthraniloyl tripeptide side chain with a terminal N,N-dimethylamino group and an acetyl group at position 20^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Milliamine D (0.18 nmol; topical application; single administration) induces ear irritation in mice, with an ID₅₀²⁴of 0.18 nmol^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NMRI (ear irritation assay; tumour promotion tests strain)^[1]
Dosage:

0.18 nmol
Administration:

topical; single application
Result:

Was determined to have a 24-hour irritant dose 50 of 0.18 nmol for ear irritation.
Exhibited an irritancy (I²⁴ = 1/ID₅₀²⁴) of 5.6 nmol^-1.

Chemical Information

No. CAS 88524-59-8
Peso molecular 791.88
Fòrmula C₄₅H₄₉N₃O₁₀
SMILES

O=C(O[C@@H]1C(COC(C)=O)=C[C@](C2=O)([H])[C@@]3([H])[C@@](C3(C)C)([H])C[C@@H](C)[C@@]42[C@]1(O)[C@@H](O)C(C)=C4)C5=CC=CC=C5NC(C6=CC=CC(O)=C6NC(C7=CC=CC=C7N(C)C)=O)=O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Marston A, et al. On the Active Principles of the Euphorbiaceae VI: Isolation and Biological Activities of Seven Milliamines from Euphorbia milii. Planta Med,1983,47(3):141-147.

[2]. Carlos Leomar Zani, et al. Molluscicidal milliamines from Euphorbia milii var. hislopii, Phytochemistry,
Volume 34, Issue 1, 1993, Pages 89-95, ISSN 0031-9422.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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