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Referencia número: HY-175748

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MK-7337

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MK-7337 is an α-synuclein ligand with an affinity of < 1 nM. MK-7337 labeled with ¹¹C can be used as a PET tracer for neurodegenerative disorders like Parkinson’s disease imagination.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 98.14%
No. CAS: 3056154-69-6
Fòrmula: C₂₄H₂₅N₉O
Peso molecular:455.52

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MK-7337 Chemical Structure

No. CAS: 3056154-69-6

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- In Vitro
- In Vivo
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Actividad biológica

Descripciòn

MK-7337 is an α-synuclein ligand with an affinity of < 1 nM. MK-7337 labeled with ¹¹C can be used as a PET tracer for neurodegenerative disorders like Parkinson’s disease imagination^[1].

Ver todos los productos específicos de isoformas Radionuclide-Drug Conjugates (RDCs) :

Ver todos los productos específicos de isoformas α-synuclein :

In Vitro

MK-7337 binds with high affinity (< 1 nM) to alpha-synuclein pathology in postmortem human PD, Alzheimer’s disease, and non-diseased brain tissues, with moderate off-target binding liability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

^[11C]MK-7337 exhibits strongly displaceable binding to α-synuclein pathological structures in the brain/brainstem of aged A30P transgenic mice^[1].
^[11C]MK-7337 exhibits favorable brain kinetic properties and a moderate risk of off-target binding in non-human primates without pathological conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3056154-69-6
Appearance Solid
Peso molecular 455.52
Fòrmula C₂₄H₂₅N₉O
Color Off-white to light yellow
SMILES

COC[C@H]1CN(CCN1C2=NC=CC=N2)C3=NC=C(C=N3)/C=C/C4=CC=C(N=C4)N5C=CN=C5
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Helen Mitchell, et al. Discovery of [11C]MK-7337, a novel high-affinity alpha-synuclein PET ligand for imaging in idiopathic Parkinson’s disease patients. ACS. 2025 Aug 20.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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MK-7337

MCE Bioactive Compound Library

Ver todos los productos específicos de isoformas Radionuclide-Drug Conjugates (RDCs)

Ver todos los productos específicos de isoformas α-synuclein

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MK-7337 Related Classifications

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