ML243
ML243 is a selective small-molecule inhibitor of breast cancer stem cells. ML243 has 32-fold greater selective inhibition in the breast CSC-like cell line HMLE_shECad than the control cell line HMLE_shGFP. ML243 may target the Wnt pathway at the protein level without altering RNA expression levels.
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- No. CAS: 1426576-80-8
- Fòrmula: C14H16N2OS
- Peso molecular:260.35
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Breast CSCs[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HMLE | EC50 |
2 μM
Compound: 19d, ML243
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Cytotoxicity against human CSC-like HMLE cells expressing shRNA and epithelial cadherin after 70 to 74 hrs by Cell Titer Glo assay
Cytotoxicity against human CSC-like HMLE cells expressing shRNA and epithelial cadherin after 70 to 74 hrs by Cell Titer Glo assay
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[PMID: 23403082] |
| HMLE | EC50 |
63.98 μM
Compound: 19d, ML243
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Cytotoxicity against human HMLE cells expressing shRNA and GFP after 70 to 74 hrs by Cell Titer Glo assay
Cytotoxicity against human HMLE cells expressing shRNA and GFP after 70 to 74 hrs by Cell Titer Glo assay
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[PMID: 23403082] |
Chemical Information
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No. CAS 1426576-80-8
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Peso molecular 260.35
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Fòrmula C14H16N2OS
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SMILES
CCC1=CC=C(/C=C/C(NC2=NCCS2)=O)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ML243 Related Classifications
HY-19972 Related Classifications
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