oJak-989
oJak-989 is a selective JAK1 inhibitor with a Ki of 2.8 nM for JAK1, 110 nM for JAK3, and 31 nM for TYK2. oJak-989 is applicable to the research of inflammatory diseases.
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- No. CAS: 1315485-91-6
- Fòrmula: C15H18N4O2
- Peso molecular:286.34
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
JAK1 2.8 nM (Ki) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| TF-1 | EC50 |
110 nM
Compound: 21
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Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins
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[PMID: 23659214] |
| TF-1 | EC50 |
180 nM
Compound: 21
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Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins in presence of whole blood
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins in presence of whole blood
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[PMID: 23659214] |
In Vitro
oJak-989 (Compound 21) is a potent and highly JAK1-selective inhibitor with a JAK1 Ki of 2.8 nM. It exhibits 26-fold selectivity over JAK2 in biochemical assays and 51-fold selectivity in cellular assays. Additionally, it possesses favorable MDCK permeability, low whole blood potency shift, high water solubility, and shows no significant hERG or clinically relevant CYP inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1315485-91-6
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Peso molecular 286.34
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Fòrmula C15H18N4O2
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SMILES
[C@H](C)(O)C=1N(C2=C3C(NC=C2N1)=NC=C3)[C@H]4CCCOC4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
oJak-989 Related Classifications
HY-W635076 Related Classifications
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