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Referencia número: HY-P10234

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Poneratoxin

Name: Poneratoxin
Brand: MedChemExpress
SKU: HY-P10234
Availability: PreOrder

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Poneratoxin is the modulator for voltage-gated sodium channel (NaV, EC₅₀ for NaV1.6 and NaV1.7 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals.

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No. CAS: 137084-94-7
Fòrmula: C₁₂₉H₂₁₅N₃₃O₃₁S
Peso molecular:2756.35

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Poneratoxin Chemical Structure

No. CAS: 137084-94-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vivo
Chemical Information
Publications (3)
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Sodium Channel :

In Vivo

Poneratoxin causes immediate and long-lasting nocifensive behaviours (20 to 600 pmol, intraplantar injection, single dose) in C57BL/6 J mice model, and leads to paralysis with PD₅₀ (1 h) of 74.3 nmol/g in blowflies model (0-100 nmol/g, ip, single dose)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 J mice model^[1]
Dosage:

20 to 600 pmol
Administration:

intraplantar injection, single dose
Result:

Caused spontaneous nocifensive behaviours.

Animal Model:

blowflies model^[1]
Dosage:

0-100 nmol/g
Administration:

Ip, single dose
Result:

Caused paralysis.

Chemical Information

No. CAS 137084-94-7
Peso molecular 2756.35
Fòrmula C₁₂₉H₂₁₅N₃₃O₃₁S
Sequence

Phe-Leu-Pro-Leu-Leu-Ile-Leu-Gly-Ser-Leu-Leu-Met-Thr-Pro-Pro-Val-Ile-Gln-Ala-Ile-His-Asp-Ala-Gln-Arg-NH2
Sequence Shortening

FLPLLILGSLLMTPPVIQAIHDAQR-NH2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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PLoS Biol

Amyloid precursor protein modulates cerebellar Purkinje cell activity and motor function through regulation of Nav1.6 currents. [Abstract]

2025 Nov 24;23(11):e3003513. PMID: 41284713
Sci Rep

Poneratoxin as a key tool for investigating the relationship between sodium channel hypersensitivity and impaired nerve cell function. [Abstract]

2025 Jul 16;15(1):25854. PMID: 40670556
Bioorg Med Chem

D-DARTS: an alternative method for NaV1.5 affinity molecules identification based on dual-drug affinity responsive target stability. [Abstract]

2026 Jan 1:132:118436. PMID: 41086654

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Robinson SD, et al., Ant venoms contain vertebrate-selective pain-causing sodium channel toxins. Nat Commun. 2023 May 23;14(1):2977. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Poneratoxin

3 Cited Publications

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Actividad biológica
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Publications (3)
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Poneratoxin

Publications Citing Use of MedChemExpress (MCE) Poneratoxin

Ver todos los productos específicos de isoformas Sodium Channel

Actividad biológica

Chemical Information

Publications (3)

Pureza y Documentación

Referencias

Calculators

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Poneratoxin Related Classifications

HY-P10234 Related Classifications

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