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Referencia número: HY-69317

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RS14203

Name: RS14203
Brand: MedChemExpress
SKU: HY-69317
Availability: PreOrder

(Synonyms: PMNPQ)

RS14203 is an orally active type IV cyclic nucleotide phosphodiesterase (PDE IV) inhibitor which can induce emesis.

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No. CAS: 159925-31-2
Fòrmula: C₂₁H₁₅N₃O₂
Peso molecular:341.36

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

RS14203 Chemical Structure

No. CAS: 159925-31-2

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Descripciòn

RS14203 is an orally active type IV cyclic nucleotide phosphodiesterase (PDE IV) inhibitor which can induce emesis^[1].

IC₅₀ & Target

PDE4

Ver todos los productos específicos de isoformas Phosphodiesterase (PDE) :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	0.07 nM Compound: 5	Inhibition of recombinant human PDE4A expressed in Sf9 cells Inhibition of recombinant human PDE4A expressed in Sf9 cells	[PMID: 11052785]
Sf9	IC₅₀	5 nM Compound: 11; CHEMBL127944	Inhibition of recombinant human PDE4D7 catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate Inhibition of recombinant human PDE4D7 catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate	[PMID: 26908025]
Sf9	IC₅₀	70 pM Compound: 11; CHEMBL127944	Inhibition of recombinant human PDE4B catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate Inhibition of recombinant human PDE4B catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate	[PMID: 26908025]

Chemical Information

No. CAS 159925-31-2
Peso molecular 341.36
Fòrmula C₂₁H₁₅N₃O₂
SMILES

O=[N+]([O-])C1=CC=CC(C2=CC(CC3=CC=NC=C3)=CC4=C2N=CC=C4)=C1
Synonyms

PMNPQ
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Robichaud A, et al. Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret. Neuropharmacology. 1999 Feb;38(2):289-97. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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RS14203

Ver todos los productos específicos de isoformas Phosphodiesterase (PDE)

Actividad biológica

Descripciòn

IC50 & Target

Cellular Effect

Chemical Information

Pureza y Documentación

Referencias

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RS14203 Related Classifications

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