Selepressin
Based on 1 Customer Validation
Selepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.17%
- No. CAS: 876296-47-8
- Fòrmula: C46H73N13O11S2
- Peso molecular:1048.28
-
Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas Vasopressin Receptor
More
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | EC50 |
1100 nM
Compound: 45, FE 202158
|
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
|
[PMID: 21688787] |
| Flp-In-293 | EC50 |
340 nM
Compound: 45, FE 202158
|
Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay
Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay
|
[PMID: 21688787] |
| HEK293 | EC50 |
0.55 nM
Compound: 45, FE 202158
|
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
|
[PMID: 21688787] |
| HEK293 | EC50 |
2.4 nM
Compound: 45, FE 202158
|
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
|
[PMID: 21688787] |
| HEK293 | EC50 |
2700 nM
Compound: 45, FE 202158
|
Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay
Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay
|
[PMID: 21688787] |
Selepressin (100 nM, 48 or 72 h) ameliorates thrombin or VEGF-induced HLMVECs barrier dysfunction[4].
Selepressin (1-1000 nM, 72 h) prevents the LPS-Induced loss of VE-cadherin and cortical actin in HLMVECs[4].
Selepressin (100 nM, 48 h) induces the expression of the barrier-protective p53 in HLMVECs[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HLMVECs
-
Concentration:1, 10, 100, 1000 nM
-
Incubation Time:24 h, 48 h
-
Result:Induced p53 expression levels, but only after treatment of 48 hours at 100 nM.
Selepressin (7 pmol/kg/min, 10 μL/min, i.v. infusion) blocks vascular leak in ovine severe sepsis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:LPS-induced, fluid-resuscitated rabbit endotoxemia model[2].
-
Dosage:1 μg/kg/min
-
Administration:Left jugular vein infusion for 12 min
-
Result:Decreased mesenteric blood flow (MBF) and increased mesenteric vascular resistance in non-endotoxemic and endotoxemic rabbits.
Chemical Information
-
No. CAS 876296-47-8
-
Appearance Solid
-
Peso molecular 1048.28
-
Fòrmula C46H73N13O11S2
-
Color White to off-white
-
Synonyms
FE 202158
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
DMSO : ≥ 100 mg/mL (95.39 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (280 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Russell JA, et al. Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients. Crit Care. 2017 Aug 15;21(1):213. [Content Brief]
[2]. Milano SP, et al. Selepressin, a novel selective V1A receptor agonist: Effect on mesenteric flow and gastric mucosa perfusion in the endotoxemic rabbit. Peptides. 2020 Jul;129:170318. [Content Brief]
[3]. Barabutis N, et al. Protective Mechanism of the Selective Vasopressin V1A Receptor Agonist Selepressin against Endothelial Barrier Dysfunction. J Pharmacol Exp Ther. 2020 Nov;375(2):286-295. [Content Brief]
[4]. Maybauer MO, et al. The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*. Crit Care Med. 2014 Jul;42(7):e525-e533. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9539 mL | 4.7697 mL | 9.5394 mL | 23.8486 mL |
| 5 mM | 0.1908 mL | 0.9539 mL | 1.9079 mL | 4.7697 mL | |
| 10 mM | 0.0954 mL | 0.4770 mL | 0.9539 mL | 2.3849 mL | |
| 15 mM | 0.0636 mL | 0.3180 mL | 0.6360 mL | 1.5899 mL | |
| 20 mM | 0.0477 mL | 0.2385 mL | 0.4770 mL | 1.1924 mL | |
| 25 mM | 0.0382 mL | 0.1908 mL | 0.3816 mL | 0.9539 mL | |
| 30 mM | 0.0318 mL | 0.1590 mL | 0.3180 mL | 0.7950 mL | |
| 40 mM | 0.0238 mL | 0.1192 mL | 0.2385 mL | 0.5962 mL | |
| 50 mM | 0.0191 mL | 0.0954 mL | 0.1908 mL | 0.4770 mL | |
| 60 mM | 0.0159 mL | 0.0795 mL | 0.1590 mL | 0.3975 mL | |
| 80 mM | 0.0119 mL | 0.0596 mL | 0.1192 mL | 0.2981 mL |
Selepressin Related Classifications
HY-105239 Related Classifications
Powered by Bioz