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Referencia número: HY-181828

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SePP

SePP is a blood-brain barrier-permeable NMDAR antagonist and dopamine/norepinephrine reuptake inhibitor, with a K_i of 28.7 nM for rat NMDAR. SePP exerts anticonvulsant effects. SePP can be used in research related to fragile X syndrome.

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Fòrmula: C₁₇H₂₁NSe
Peso molecular:318.32

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

SePP Chemical Structure

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

NMDA Receptor

28.7 nM (Ki)

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In Vitro

SePP (multiple concentrations; 2 h) potently binds to rat forebrain NMDARs with a K_i of 28.7 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	Plasma Concentration
Mice^[1]	10 mg/kg	i.p.	387.5 ng/mL

In Vivo

SePP (10 mg/kg; i.p.) completely suppresses audiogenic seizures in juvenile Fmr1 knockout mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

FVB.129P2-Pde6b+ Tyrc‑ch Fmr1tm1Cgr/J (Fmr1 knockout, 4 male and 4 female, postnatal day 23-25, audiogenic seizure induction)^[1]
Dosage:

10 mg/kg
Administration:

i.p.; single dose
Result:

Abolished wild running and jumping (WRJ), tonic-clonic seizure (TCS), and respiratory arrest (RA) in all treated mice, with statistically significant differences compared to vehicle controls (P < 0.0001 for WRJ and TCS, P = 0.0013 for RA).
Exhibited normal behaviors including exploring, rearing, grooming, and interacting with cage-mates during testing.

Chemical Information

Peso molecular 318.32
Fòrmula C₁₇H₂₁NSe
SMILES

C1(CC(N2CCCCC2)C3=CC=C[Se]3)=CC=CC=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Wallach J, et al. Bioisostere-Driven Discovery of SePP: A Selenium-Containing Polypharmacological Agent Relevant to Fragile X Syndrome. J Med Chem. 2026;69(4):4020-4036. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
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SePP

Ver todos los productos específicos de isoformas iGluR

Ver todos los productos específicos de isoformas Dopamine Receptor

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

SePP Related Classifications

HY-181828 Related Classifications