SYHA1815
SYHA1815 is an orally active RET inhibitor (IC50=0.9 nmol/L) with antitumor activity. SYHA1815 is more selective for RET than KDR (IC50=15.9 nmol/L). SYHA1815 arrests the G1 cell cycle and inhibits RET-driven cell proliferation by downregulating c-Myc.
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- No. CAS: 2760195-67-1
- Fòrmula: C27H26ClF4N5O
- Peso molecular:547.97
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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RET 0.9 nM (IC50) |
KRD 15.9 nM (IC50) |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 2760195-67-1
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Peso molecular 547.97
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Fòrmula C27H26ClF4N5O
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SMILES
CN(CC1)CCN1CC2=C(C(F)(F)F)C=C(NC(C3=CC(F)=CC(C#CC4=CC=CN=C4N)=C3)=O)C=C2.Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SYHA1815 Related Classifications
HY-149451 Related Classifications
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