Tauromustine
Tauromustine is an orally active nitrosourea anticancer agent. Tauromustine has an alkylation effect and can damage the DNA function. Tauromustine has a high therapeutic index, especially in the study of Walker 256 rat sarcoma. It is also active against melanoma, breast cancer, pleural mesothelioma and ovarian cancer. Tauromustine is mainly metabolized in the liver, but some of its metabolites also have cytotoxicity.
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- No. CAS: 85977-49-7
- Fòrmula: C7H15ClN4O4S
- Peso molecular:286.74
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
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Actividad biológica
Chemical Information
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No. CAS 85977-49-7
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Peso molecular 286.74
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Fòrmula C7H15ClN4O4S
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SMILES
O=NN(CCCl)C(NCCS(=O)(N(C)C)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Gregor A, et al. Phase II study of tauromustine in malignant glioma. Eur J Cancer. 1992;28A(12):1959-62. [Content Brief]
[2]. Smyth JF, et al. Two phase III trials of tauromustine (TCNU) in advanced colorectal cancer. Ann Oncol. 1995 Nov;6(9):948-9. [Content Brief]
[3]. Bibby MC, et al. Influence of hydralazine on the pharmacokinetics of tauromustine (TCNU) in mice. Br J Cancer. 1992 Mar;65(3):347-50. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tauromustine Related Classifications
HY-119916 Related Classifications
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