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Referencia número: HY-119407

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Terpendole E

Terpendole E is a mitotic kinesin Eg5 inhibitor. Terpendole E inhibits both motor and microtubule-stimulated ATPase activities of human Eg5. Terpendole E induces formation of a monoastral spindle in M phase.

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No. CAS: 167427-23-8
Fòrmula: C₂₈H₃₉NO₃
Peso molecular:437.61

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Terpendole E Chemical Structure

No. CAS: 167427-23-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

Eg5

Ver todos los productos específicos de isoformas Kinesin :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	31.1 μM Compound: 9	Cytotoxicity against human A2780 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A2780 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26356746]
A549	IC₅₀	18.82 μM Compound: 9	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26356746]
HeLa	IC₅₀	12.1 μM Compound: 10	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by SF-based cell counting method Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by SF-based cell counting method	[PMID: 27865702]
K562	IC₅₀	38.7 μM Compound: 9	Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26356746]
MDA-MB-231	IC₅₀	39.22 μM Compound: 9	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26356746]

Chemical Information

No. CAS 167427-23-8
Peso molecular 437.61
Fòrmula C₂₈H₃₉NO₃
SMILES

C[C@]12C3=C(C4=CC=CC=C4N3)C[C@]1([H])CC[C@]5([H])[C@@]2(CC[C@@]6([H])[C@]5([C@@H](C[C@H](O6)C(C)(O)C)O)C)C
Structure Classification
- Terpenoids
- Iridoids
Initial Source
- Microorganisms
soil-isolated fungus
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Junko Nakazawa, et al. A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5. Chem Biol. 2003 Feb;10(2):131-7. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Terpendole E

Ver todos los productos específicos de isoformas Kinesin

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Terpendole E Related Classifications

HY-119407 Related Classifications