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Referencia número: HY-122903S

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TK216-d₄

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TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 98.52%
No. CAS: 3034816-36-6
Fòrmula: C₁₉H₁₁D₄Cl₂NO₃
Peso molecular:380.26

Almacenamiento:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

TK216-d₄ Chemical Structure

No. CAS: 3034816-36-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- Aplicación
Chemical Information
Pureza y Documentación
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor^[1]. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity^[2].

IC₅₀ & Target

Helicase

Ver todos los productos específicos de isoformas DNA/RNA Synthesis :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aplicación

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

No. CAS 3034816-36-6
Unlabeled Cas 1903783-48-1
Appearance Solid
Peso molecular 380.26
Fòrmula C₁₉H₁₁D₄Cl₂NO₃
Color White to off-white
SMILES

O=C1NC2=C(C1(O)CC(C3=C([2H])C([2H])=C(C([2H])=C3[2H])C4CC4)=O)C(Cl)=CC=C2Cl
Envío

Room temperature in continental US; may vary elsewhere.