VPC12249
VPC12249 is a competitive dual LPA1/LPA3 antagonist with Ki values of 137nM and 428 nM, respectively. VPC12249 inhibits calcium mobilization in HEK293T cells with a Ki value of ~130 nM. VPC12249 is promising for research of ovarian cancer and hypertensive diseases.
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- No. CAS: 403520-23-0
- Fòrmula: C34H52NO6P
- Peso molecular:601.75
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
>10000 nM
Compound: 14a
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In vitro antagonism of LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 3 in HEK293T cell lines
In vitro antagonism of LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 3 in HEK293T cell lines
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[PMID: 15125924] |
| HEK-293T | IC50 |
>10000 nM
Compound: 14a
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In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines
In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines
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[PMID: 15125924] |
| HEK-293T | IC50 |
5210 nM
Compound: 20
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Antagonist activity at mouse LPA1 receptor transfected in HEK293T cells
Antagonist activity at mouse LPA1 receptor transfected in HEK293T cells
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10.1039/C4MD00333K |
| HEK-293T | IC50 |
6450 nM
Compound: 20
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Antagonist activity at human LPA3 receptor transfected in HEK293T cells
Antagonist activity at human LPA3 receptor transfected in HEK293T cells
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10.1039/C4MD00333K |
Chemical Information
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No. CAS 403520-23-0
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Peso molecular 601.75
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Fòrmula C34H52NO6P
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SMILES
CCCCCCCC/C=C\CCCCCCCC(N[C@@H](CC1=CC=C(OCC2=CC=CC=C2)C=C1)COP(O)(O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VPC12249 Related Classifications
HY-129808 Related Classifications
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