VU6033685
VU6033685 is the orally active positive allosteric modulator (PAM) for mGlu1 that positively modulates human mGlu1 and human mGlu5 with EC50 of 39 nM and 3960 nM. VU6033685 also inhibits CYP1A2, CYP2C9 and CYP2D6 with IC50 of 26, 22.3 and 23.8 μM, respectively. VU6033685 reverses amphetamine-induced rats hyperlocomotion, protects rats from MK-801 (HY-15084B)-induced cognitive impairment. VU6033685 exhibits good pharmacokinetics characteristics in rats with an oral bioavailability of 42.8%.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C20H19ClN4O
- Peso molecular:366.84
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
EC50: human mGlu5 (39 nM); human mGlu5 (3960 nM)
IC50: CYP1A2 (26 μM); CYP2C9 (22.3 μM); CYP2D6 (23.8 μM)
Chemical Information
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Peso molecular 366.84
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Fòrmula C20H19ClN4O
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SMILES
CC1=NC(C2CC2)=CC=C1CNC(C3=CC(N4C=CC=N4)=CC=C3Cl)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VU6033685 Related Classifications
HY-173032 Related Classifications
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