Zorevunersen
Based on 1 Customer Validation
Zorevunersen is an antisense oligonucleotide targeting the Scn1a gene based on TANGO technology. Zorevunersen increases Scn1a mRNA transcripts and elevates the expression level of NaV1.1 protein. Zorevunersen restores the excitability of PV interneurons, thereby reducing seizures and prolonging survival in mice. Zorevunersen can be used for research on Dravet syndrome.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.50%
- No. CAS: 2415330-04-8
- Fòrmula: C204H263N63O114P20S20
- Peso molecular:7197.20
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Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:75% C57BL/6:25% 129S6/SvEvTac (Scn1a+/− Dravet Syndrome model)[1]
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Dosage:20 μg
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Administration:i.c.v.; single unilateral injection; postnatal day 2 (P2)
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Result:Completely prevented seizures in pre-weaning cohort.
Significantly reduced seizure frequency in post-weaning cohort.
Prolonged survival in post-weaning cohort.
Restored PV interneuron intrinsic excitability to vehicle-treated wild-type levels.
Significantly elevated action potential firing frequencies compared to vehicle-treated Scn1a+/− mice .
Failed to rescue reduced AP upstroke velocity of vehicle-treated Scn1a+/− PV interneurons.
Caused no significant difference in seizure frequency compared to vehicle-treated WT mice in wild-type cohort.
Significantly reduced PV interneuron excitability relative to vehicle-treated WT mice in wild-type cohort.
Chemical Information
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No. CAS 2415330-04-8
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Appearance Solid
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Peso molecular 7197.20
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Fòrmula C204H263N63O114P20S20
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Color White to off-white
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SMILES
[Zorevunersen]
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Synonyms
STK-001
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2242 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Zorevunersen Related Classifications
HY-148410 Related Classifications
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