Hmgcr - 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Gene

Also Known as Red; HMG-CoAR

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15357

About Hmgcr

Chromosome 13: 96,785,475-96,807,444 reverse strand.GRCm39:CM001006.3

This gene has 11 transcripts (splice variants), 206 orthologues and is associated with 3 phenotypes. Broad expression in CNS E18 (RPKM 39.9), CNS E11.5 (RPKM 3.5) and 25 other tissues.

Summary

Enables hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in negative regulation of amyloid-beta clearance; negative regulation of protein catabolic process; and negative regulation of protein secretion. Acts upstream of or within Cholesterol biosynthetic process; negative regulation of MAP kinase activity; and visual learning. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in several structures, including autopod; branchial arch; central nervous system; forelimb bud; and ganglia. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]

Hmgcr Products (3)

mRNA Protein Name
NM_001360166.1 NP_001347095.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 2
NM_001360165.1 NP_001347094.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1
NM_008255.2 NP_032281.2 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables GTPase regulator activity IGI
IGI: Inferred from genetic interaction
16271875 MGI
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IDA
IDA: Inferred from direct assay
1352323 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cholesterol biosynthetic process IDA
IDA: Inferred from direct assay
7798939 MGI
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
12920113 MGI
acts upstream of or within long-term synaptic potentiation IGI
IGI: Inferred from genetic interaction
16271875 MGI
acts upstream of or within negative regulation of MAP kinase activity IGI
IGI: Inferred from genetic interaction
12409258 MGI
involved in negative regulation of amyloid-beta clearance IMP
IMP: Inferred from mutant phenotype
20876579 MGI
involved in negative regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
20876579 MGI
involved in negative regulation of protein secretion IMP
IMP: Inferred from mutant phenotype
20876579 MGI
acts upstream of or within regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
16271875 MGI
acts upstream of or within visual learning IGI
IGI: Inferred from genetic interaction
16271875 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hmgcr Protein Structure

2A060605

2A060605: TIGR00920 (0 - 886)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 887 a.a.
Protein Preferred Names Protein Names

3-hydroxy-3-methylglutaryl-coenzyme A reductase

  • 3-hydroxy-3-methylglutaryl-CoA reductase

  • HMG-CoA reductase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17504 Rosuvastatin Calcium 99.62% Yes
HY-17504B Rosuvastatin Sodium 99.91% Yes
HY-119695A Simvastatin acid ammonium Inhibitor 99.70% Unkown
HY-115292 Simvastatin hydroxy acid sodium Inhibitor 99.86% Unkown
HY-119695 Simvastatin acid Inhibitor 98.99% Unkown
HY-119695B Simvastatin acid calcium hydrate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-N0466 Rebaudioside A 98.0% Phase 1

Pre-clinical Phase

Bioactive Molecules (40)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107855 DL-Mevalonolactone 99.15% Unkown
HY-15483 DY131 99.72% Unkown
HY-N6712 Thiolutin Inhibitor 99.27% Unkown
HY-N0686 Pseudoprotodioscin Inhibitor 99.17% Unkown
HY-111355 Cholesterol sulfate 98.49% Unkown
HY-135700 Mevalonolactone 98.0% Unkown
HY-N0430A Coptisine Sulfate 99.37% Unkown
HY-17504BS Rosuvastatin-d3 sodium 99.93% Unkown
HY-17504R Rosuvastatin Calcium (Standard) 99.94% Unkown
HY-W414548 7α,27-Dihydroxycholesterol 99.93% Unkown
HY-114316 HMG499 Inhibitor 96.12% Unkown
HY-142026 Vitisin A 97% Unkown
HY-17504BS1 Rosuvastatin-d6 sodium Inhibitor 99.9% Unkown
HY-106281 Bemfivastatin Inhibitor 99.48% Unkown
HY-106281A Bemfivastatin hemicalcium Inhibitor 98.00% Unkown
HY-17504S Rosuvastatin-d6 calcium 98.54% Unkown
HY-N0430 Coptisine / Unkown
HY-RS06238 HMGCR Human Pre-designed siRNA Set A / Unkown
HY-W740010 N-Desmethyl rosuvastatin disodium hydrate 99.1% Unkown
HY-17504BS2 Rosuvastatin-13C,d3 sodium 98.31% Unkown
HY-N11637 Ganoderenic acid K Inhibitor 99.64% Unkown
HY-107855S2 DL-Mevalonolactone-13C / Unkown
HY-107855S4 DL-Mevalonolactone-13C2 / Unkown
HY-115292S Simvastatin hydroxy acid-d6 sodium Inhibitor / Unkown
HY-116241 L-157012 Inhibitor / Unkown
HY-119695AS1 Simvastatin acid-d9 ammonium Inhibitor / Unkown
HY-147195 QH536 Inhibitor / Unkown
HY-171823 PROTAC HMGCR Degrader-1 Degrader / Unkown
HY-181134 PROTAC HMGCR Degrader-2 / Unkown
HY-184354 NO-Pravastatin / Unkown
HY-N11637A (Z)-Ganoderenic acid K Control / Unkown
HY-N16439 Phenicin Inhibitor / Unkown
HY-P11881 IUB288 / Unkown
HY-RS06239 Hmgcr Mouse Pre-designed siRNA Set A / Unkown
HY-RS06240 Hmgcr Rat Pre-designed siRNA Set A / Unkown
HY-W752587 DL-Mevalonolactone-d4 / Unkown
HY-107855R DL-Mevalonolactone (Standard) / Unkown
HY-119695S Simvastatin acid-d6 Inhibitor / Unkown
HY-136345A 3'-Hydroxy simvastatin 99.71% Unkown
HY-187569 (Rac)-3-OH-Simvastatin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmgcr NCBI NCBI:3156