Lrp6 - low density lipoprotein receptor-related protein 6 Gene

Also Known as Cd; Gw; ska26; skax26; ska; C030016K15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16974

Summary

Enables Wnt-protein binding activity; Apolipoprotein binding activity; and toxin transmembrane transporter activity. Involved in cell surface receptor signaling pathway involved in cell-cell signaling; positive regulation of neuron projection development; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of Wnt signaling pathway, planar cell polarity pathway. Located in early endosome and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study fatty liver disease and neural tube defect. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human LRP6 (LDL receptor related protein 6). [provided by Alliance of Genome Resources, Apr 2022]

Lrp6 Products (1)

mRNA Protein Name
NM_008514.4 NP_032540.2 low-density lipoprotein receptor-related protein 6 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
18606138 MGI
enables apolipoprotein binding IPI
IPI: Inferred from physical interaction
18948618 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12573468 MGI
enables toxin transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
16564009 MGI
Biological Process GO Annotation Evidence References Source
involved in Norrin signaling pathway IDA
IDA: Inferred from direct assay
15035989 MGI
acts upstream of or within Wnt signaling pathway involved in forebrain neuroblast division IGI
IGI: Inferred from genetic interaction
14715945 MGI
acts upstream of or within Wnt signaling pathway involved in forebrain neuroblast division IMP
IMP: Inferred from mutant phenotype
16920270 MGI
acts upstream of or within Wnt signaling pathway involved in somitogenesis IMP
IMP: Inferred from mutant phenotype
15469977 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
15142971 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
16126904 MGI
acts upstream of or within axis elongation IMP
IMP: Inferred from mutant phenotype
19795512 MGI
acts upstream of or within axis elongation involved in somitogenesis IGI
IGI: Inferred from genetic interaction
11029008 MGI
acts upstream of or within bone remodeling IGI
IGI: Inferred from genetic interaction
15537447 MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
19503830 MGI
involved in canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
11029008 MGI
acts upstream of or within canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19705442 MGI
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
15064719 MGI
acts upstream of cardiac muscle tissue morphogenesis IGI
IGI: Inferred from genetic interaction
19056682 MGI
acts upstream of or within cell migration involved in gastrulation IGI
IGI: Inferred from genetic interaction
15142971 MGI
acts upstream of or within cerebellum morphogenesis IMP
IMP: Inferred from mutant phenotype
11029008 MGI
acts upstream of or within cerebral cortex cell migration IMP
IMP: Inferred from mutant phenotype
16920270 MGI
acts upstream of or within cerebral cortex development IMP
IMP: Inferred from mutant phenotype
16920270 MGI
acts upstream of or within convergent extension IGI
IGI: Inferred from genetic interaction
19795512 MGI
acts upstream of or within dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
19795519 MGI
acts upstream of or within dorsal/ventral axis specification IMP
IMP: Inferred from mutant phenotype
18985738 MGI
acts upstream of or within embryonic camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
18985738 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
15142971 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
19795512 MGI
acts upstream of or within embryonic forelimb morphogenesis IGI
IGI: Inferred from genetic interaction
15880584 MGI
acts upstream of or within embryonic forelimb morphogenesis IMP
IMP: Inferred from mutant phenotype
11029008 MGI
acts upstream of or within embryonic hindlimb morphogenesis IGI
IGI: Inferred from genetic interaction
15880584 MGI
acts upstream of or within embryonic hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
19653321 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
20359476 MGI
acts upstream of or within embryonic pattern specification IMP
IMP: Inferred from mutant phenotype
19653321 MGI
acts upstream of or within embryonic retina morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
19653321 MGI
acts upstream of or within establishment of blood-brain barrier IMP
IMP: Inferred from mutant phenotype
25083995 MGI
acts upstream of or within establishment of blood-retinal barrier IMP
IMP: Inferred from mutant phenotype
25083995 MGI
acts upstream of or within external genitalia morphogenesis IMP
IMP: Inferred from mutant phenotype
19653321 MGI
acts upstream of or within face morphogenesis IMP
IMP: Inferred from mutant phenotype
19653321 MGI
acts upstream of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
17888405 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
15384171 MGI
acts upstream of or within forebrain generation of neurons IMP
IMP: Inferred from mutant phenotype
14715945 MGI
acts upstream of or within forebrain radial glial cell differentiation IGI
IGI: Inferred from genetic interaction
14715945 MGI
acts upstream of or within formation of radial glial scaffolds IGI
IGI: Inferred from genetic interaction
14715945 MGI
acts upstream of or within gastrulation with mouth forming second IGI
IGI: Inferred from genetic interaction
15142971 MGI
acts upstream of or within generation of neurons IMP
IMP: Inferred from mutant phenotype
15342729 MGI
acts upstream of or within heart looping IGI
IGI: Inferred from genetic interaction
19795512 MGI
acts upstream of or within limb morphogenesis IGI
IGI: Inferred from genetic interaction
15537447 MGI
acts upstream of or within limb morphogenesis IMP
IMP: Inferred from mutant phenotype
15469977 MGI
acts upstream of or within mammary gland duct morphogenesis IGI
IGI: Inferred from genetic interaction
19503830 MGI
acts upstream of or within mammary placode formation IMP
IMP: Inferred from mutant phenotype
19503830 MGI
acts upstream of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
19700620 MGI
acts upstream of or within mesodermal cell migration IGI
IGI: Inferred from genetic interaction
15142971 MGI
acts upstream of or within midbrain development IMP
IMP: Inferred from mutant phenotype
11029008 MGI
acts upstream of or within midbrain-hindbrain boundary development IMP
IMP: Inferred from mutant phenotype
11029008 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
19700620 MGI
acts upstream of or within negative regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
17888405 MGI
acts upstream of or within negative regulation of non-canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19056682 MGI
acts upstream of neural tube closure IGI
IGI: Inferred from genetic interaction
19056682 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
19795512 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
10545599 MGI
acts upstream of or within neural tube development IGI
IGI: Inferred from genetic interaction
19795512 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
591875 MGI
acts upstream of outflow tract morphogenesis IGI
IGI: Inferred from genetic interaction
19056682 MGI
acts upstream of pericardium morphogenesis IGI
IGI: Inferred from genetic interaction
19056682 MGI
acts upstream of or within pericardium morphogenesis IGI
IGI: Inferred from genetic interaction
19795512 MGI
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
15035989 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15035989 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19700620 MGI
acts upstream of or within positive regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
18505367 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
19700620 MGI
involved in positive regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
23845000 MGI
acts upstream of or within positive regulation of ossification IMP
IMP: Inferred from mutant phenotype
15469977 MGI
acts upstream of or within positive regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
19700620 MGI
acts upstream of or within post-anal tail morphogenesis IGI
IGI: Inferred from genetic interaction
19795512 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
19653321 MGI
acts upstream of or within primitive streak formation IGI
IGI: Inferred from genetic interaction
19795512 MGI
acts upstream of or within receptor-mediated endocytosis involved in cholesterol transport IMP
IMP: Inferred from mutant phenotype
18948618 MGI
acts upstream of or within regulation of cell development IMP
IMP: Inferred from mutant phenotype
19795519 MGI
acts upstream of or within regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
591875 MGI
acts upstream of or within response to folic acid IMP
IMP: Inferred from mutant phenotype
17050573 MGI
acts upstream of or within retina morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
18985738 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
19653321 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
15469977 MGI
acts upstream of or within somitogenesis IGI
IGI: Inferred from genetic interaction
19795512 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
19700620 MGI
acts upstream of or within thalamus development IMP
IMP: Inferred from mutant phenotype
15342729 MGI
acts upstream of or within trachea cartilage morphogenesis IGI
IGI: Inferred from genetic interaction
18256198 MGI
acts upstream of ventricular septum morphogenesis IGI
IGI: Inferred from genetic interaction
19056682 MGI
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
18948618 MGI
located in membrane IDA
IDA: Inferred from direct assay
16126904 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18505367 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 6

  • LRP-6

  • crooked

  • low density lipoprotein receptor-related protein 6

  • low density lipoprotein-related protein 6

  • low density lipoprotein-related protein 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-17439 Salinomycin sodium salt 99.81% Yes
HY-15597 Salinomycin 99.74% Yes
HY-122816 HLY78 98.44% Unkown
HY-D0961 Gallocyanine chloride Activator 92.00% Unkown
HY-70005 CPA inhibitor 99.78% Unkown
HY-170035 GlcCer (d18:1/18:0) Activator 99.93% Unkown
HY-N0836 Jervine 99.28% Unkown
HY-100853 IWP-O1 Inhibitor 99.81% Unkown
HY-160709 Wnt/β-catenin-IN-2 Inhibitor 99.46% Unkown
HY-178335 SGC-CK1γ-1 Inhibitor 99.33% Unkown
HY-RS16293 Lrp6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-176488 Y-99 Inhibitor / Unkown
HY-181160 JNK3/Wnt/β-catenin modulator-1 / Unkown
HY-181560 SLD1121 Agonist / Unkown
HY-181586 CK1γ-IN-1 Inhibitor / Unkown
HY-181930 TNIK-IN-10 / Unkown
HY-184177 W2A-28 / Unkown
HY-E70390 C1s Enzyme Antagonist / Unkown
HY-E70661 CDK14/CycY Recombinant Human Active Protein Kinase / Unkown
HY-RS07801 LRP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124841 Gallocyanine / Unkown
HY-N0836A Jervine hydriodide / Unkown
HY-RS23672 Lrp6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991311 GSK3178022 Inhibitor / Unkown
HY-P992264 Anti-LRP6 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrp6 NCBI NCBI:4040