Mmp7 - matrix metallopeptidase 7 Gene

Also Known as MAT; MMP-7

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17393

About Mmp7

Chromosome 9: 7,692,091-7,699,586 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 163 orthologues, 23 paralogues and is associated with 18 phenotypes. Biased expression in large intestine adult (RPKM 146.), small intestine adult (RPKM 25.5) and 2 other tissues.

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein are deficient in functional cryptdins. This gene is located in a cluster of Other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]

Mmp7 Products (2)

mRNA	Protein	Name
NM_010810.5	NP_034940.2	matrilysin isoform 1 preproprotein
NM_001319986.1	NP_001306915.1	matrilysin isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables peptidase activity	IDA IDA: Inferred from direct assay	20056603	MGI
enables peptidase activity	IMP IMP: Inferred from mutant phenotype	20056603	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within antibacterial peptide biosynthetic process	IMP IMP: Inferred from mutant phenotype	20056603	MGI
acts upstream of or within antibacterial peptide secretion	IMP IMP: Inferred from mutant phenotype	11248802	MGI
acts upstream of or within defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	11248802	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	11248802	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	11248802	MGI
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	20056603	MGI
acts upstream of or within proteolysis	IMP IMP: Inferred from mutant phenotype	20056603	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	9037065	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	11248802	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp7 Protein Structure

PG_binding_1

Peptidase_M10

0
100
200
267 a.a.

Protein Preferred Names	Protein Names
matrilysin	matrilysin, uterine matrin matrix metalloproteinase 7 pump-1 protease uterine metalloproteinase

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12169	Marimastat	Inhibitor	99.90%	Phase 3

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13564	Batimastat	Inhibitor	98.92%	Unkown
HY-131498	Mca-PLGL-Dpa-AR-NH2	Substrate	99.86%	Unkown
HY-103444	ARP-100	Inhibitor	≥99.0%	Unkown
HY-N0774	Isofraxidin	Inhibitor	99.94%	Unkown
HY-151540	MMP-7-IN-1	Inhibitor	99.37%	Unkown
HY-119423	MMP Inhibitor II	Inhibitor	99.7%	Unkown
HY-156430	MMP-7-IN-3	Inhibitor	99.74%	Unkown
HY-153563	MMP-7-IN-2	Inhibitor	99.08%	Unkown
HY-161169A	TP0628103 TFA	Inhibitor	99.90%	Unkown
HY-15606	Tanaproget	Agonist	99.73%	Unkown
HY-RS08552	Mmp7 Mouse Pre-designed siRNA Set A		/	Unkown
HY-13564A	Batimastat sodium salt	Inhibitor	99.04%	Unkown
HY-130076	MMP-2 Inhibitor II	Inhibitor	98.0%	Unkown
HY-P3123A	Dnp-RPLALWRS TFA		99.04%	Unkown
HY-161169	TP0628103	Inhibitor	/	Unkown
HY-181769	Anticancer agent 306		/	Unkown
HY-184162	HSP110-IN-1		/	Unkown
HY-P3123	Dnp-RPLALWRS		/	Unkown
HY-P3699	TNO003	Substrate	/	Unkown
HY-P4931A	Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA		/	Unkown
HY-RS08551	MMP7 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08553	Mmp7 Rat Pre-designed siRNA Set A		/	Unkown
HY-P3699A	TNO003 TFA	Substrate	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mmp7	NCBI	NCBI:4316