Nedd8 - neural precursor cell expressed, developmentally down-regulated gene 8 Gene

Also Known as Rub1; NEDD-8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18002

Summary

Predicted to enable protein tag and ubiquitin protein Ligase binding activity. Acts upstream of or within protein localization and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human NEDD8 (NEDD8 ubiquitin like modifier). [provided by Alliance of Genome Resources, Apr 2022]

Nedd8 Products (1)

mRNA Protein Name
NM_008683.4 NP_032709.1 NEDD8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
12215427 MGI
Biological Process GO Annotation Evidence Referencias Source
acts upstream of or within protein localization IDA
IDA: Inferred from direct assay
12215427 MGI
involved in regulation of postsynapse assembly EXP
EXP: Inferred from Experiment
25581363 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
25581363 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
25581363 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12215427 MGI
Cellular Component GO Annotation Evidence Referencias Source
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
25581363 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25581363 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25581363 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12215427 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NEDD8

  • neddylin

  • neural precursor cell expressed developmentally down-regulated protein 8

  • ubiquitin-like protein Nedd8

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-10484 Pevonedistat hydrochloride 99.19% Phase 3
HY-128586 TAS4464 99.21% Phase 1

Pre-clinical Phase

Bioactive Molecules (18)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-70062 Pevonedistat 99.98% Unkown
HY-108702 ML-792 Inhibitor 99.76% Unkown
HY-128586A TAS4464 hydrochloride 98.91% Unkown
HY-101790A ZM223 hydrochloride Inhibitor 98.93% Unkown
HY-115537 NAE-IN-M22 Activator 99.94% Unkown
HY-101790 ZM223 Inhibitor / Unkown
HY-163105 Tubulin/NEDDylation-IN-1 Inhibitor 98.03% Unkown
HY-RS09181 NEDD8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-70062R Pevonedistat (Standard) 99.51% Unkown
HY-148777 A031 Degrader / Unkown
HY-157426 PROTAC BRD4 Degrader-50 Degrader / Unkown
HY-159601 CSN5-IN-1 Inhibitor / Unkown
HY-168635 SJ46420 Inhibitor / Unkown
HY-175937 AR ligand-46 Ligand / Unkown
HY-181795 CSN5-IN-3 / Unkown
HY-177936 NAE-IN-3 Inhibitor / Unkown
HY-RS17081 Nedd8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23525 Nedd8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nedd8 NCBI NCBI:4738