Nras - neuroblastoma ras oncogene Gene

Also Known as N-ras

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18176

About Nras

Chromosome 3: 102,965,601-102,975,230 forward strand.GRCm39:CM000996.3

This gene has 9 transcripts (splice variants), 152 orthologues, 35 paralogues and is associated with 18 phenotypes.

Summary

Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in positive regulation of angiogenesis. Acts upstream of or within several processes, including T cell receptor signaling pathway; defense response to protozoan; and positive regulation of interferon-gamma production. Located in membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland Cancer (multiple); hematologic Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Nras Products (7)

mRNA Protein Name
NM_001410509.1 NP_001397438.1 GTPase NRas
NM_001368638.2 NP_001355567.1 GTPase NRas
NM_001410512.1 NP_001397441.1 GTPase NRas
NM_001410511.1 NP_001397440.1 GTPase NRas
NM_010937.3 NP_035067.2 GTPase NRas
NM_001410510.1 NP_001397439.1 GTPase NRas
NM_001410513.1 NP_001397442.1 GTPase NRas

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21444916 MGI
acts upstream of or within defense response to protozoan IMP
IMP: Inferred from mutant phenotype
21444916 MGI
acts upstream of or within negative regulation of skeletal muscle tissue development IDA
IDA: Inferred from direct assay
20534588 MGI
acts upstream of or within negative regulation of skeletal muscle tissue development IGI
IGI: Inferred from genetic interaction
20534588 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
23619365 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
23871832 MGI
acts upstream of or within positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
21444916 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23871832 MGI
acts upstream of or within regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
23871832 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
10085069 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GTPase NRas

  • transforming protein N-Ras

Orthologs Information

Species Symbol Source ID
Homo sapiens Nras NCBI NCBI:4893