Sms - spermine synthase Gene

Also Known as Gy; gyro; SPMSY; SpmST

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20603

Summary

Predicted to enable spermine synthase activity. Acts upstream of or within spermine metabolic process. Is expressed in several structures, including central nervous system; ganglia; limb; respiratory system; and tooth. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Snyder type. Orthologous to human SMS (spermine synthase). [provided by Alliance of Genome Resources, Apr 2022]

Sms Products (2)

mRNA	Protein	Name
NM_001359185.1	NP_001346114.1	spermine synthase isoform 2
NM_009214.4	NP_033240.3	spermine synthase isoform 1

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within spermine metabolic process	IMP IMP: Inferred from mutant phenotype	9467015	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
spermine synthase	spermidine aminopropyltransferase

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0036	Octreotide		99.96%	Unkown
HY-17365	Octreotide acetate	Agonist	99.93%	Unkown
HY-P0036B	Octreotide pamoate		/	Unkown

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163541	SMS121	Inhibitor	99.06%	Unkown
HY-114307	Ly93	Inhibitor	99.85%	Unkown
HY-N8518	Malabaricone C		99.46%	Unkown
HY-102041	SMS2-IN-1	Inhibitor	98.00%	Unkown
HY-135642	SMS1-IN-1	Inhibitor	98.38%	Unkown
HY-19625	MCB-613	Inducer	99.64%	Unkown
HY-112713	SMS2-IN-2	Inhibitor	98.0%	Unkown
HY-171160	WYFA-15	Inhibitor	98.77%	Unkown
HY-165136	Sphingomyelins, milk		99.20%	Unkown
HY-RS13454	SMS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-139995	Spermine Prodrug-1		/	Unkown
HY-150559	SMS2-IN-3	Inhibitor	/	Unkown
HY-157730	2-Myristyldistearin		/	Unkown
HY-P0036A	Octreotide dihydrochloride		/	Unkown
HY-RS11624	RAI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181568	PROTAC Aurora A Degrader-1		/	Unkown
HY-P0036S2	Octreotide-d8		/	Unkown
HY-P0036S3	Octreotide-13C9,15N		/	Unkown
HY-P0036S4	Octreotide-d8 acetate		/	Unkown
HY-RS17402	Sms Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23857	Sms Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P0036S	Octreotide-d8 TFA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sms	NCBI	NCBI:6611