Tead1 - TEA domain family member 1 Gene

Also Known as TEF-1; Tcf13; TEAD-1; mTEF-1; Gtrgeo5; 2610024B07Rik; B230114H05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21676

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; cellular response to retinoic acid; and hippo signaling. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; musculature; and tooth. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to human TEAD1 (TEA domain transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tead1 Products (3)

mRNA Protein Name
NM_001166584.2 NP_001160056.2 transcriptional enhancer factor TEF-1 isoform 1
NM_001166585.2 NP_001160057.2 transcriptional enhancer factor TEF-1 isoform 3
NM_009346.4 NP_033372.2 transcriptional enhancer factor TEF-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14762206 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11306707 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14762206 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to retinoic acid IDA
IDA: Inferred from direct assay
21385842 MGI
acts upstream of or within embryonic heart tube morphogenesis IGI
IGI: Inferred from genetic interaction
18332127 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
7958896 MGI
acts upstream of or within hippo signaling IGI
IGI: Inferred from genetic interaction
19004856 MGI
acts upstream of or within lateral mesoderm development IGI
IGI: Inferred from genetic interaction
18332127 MGI
acts upstream of or within notochord development IGI
IGI: Inferred from genetic interaction
18332127 MGI
acts upstream of or within paraxial mesoderm development IGI
IGI: Inferred from genetic interaction
18332127 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
26902285 MGI
acts upstream of or within positive regulation of protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18978355 MGI
acts upstream of or within positive regulation of stem cell population maintenance IGI
IGI: Inferred from genetic interaction
20516196 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11358867 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16207754 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17689488 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14762206 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
19004856 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
27288457 MGI
acts upstream of or within transition between fast and slow fiber IDA
IDA: Inferred from direct assay
18978355 MGI
Cellular Component GO Annotation Evidence References Source
part of TEAD-YAP complex IPI
IPI: Inferred from physical interaction
11358867 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19004856 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
16207754 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcriptional enhancer factor TEF-1

  • NTEF-1

  • TCF-13

  • transcription factor 13

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-172113 H122 98.33% Phase 4

Pre-clinical Phase

Bioactive Molecules (51)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134956 VT104 Inhibitor 99.94% Unkown
HY-134955 VT103 Inhibitor 99.64% Unkown
HY-147135 MYF-03-69 98.11% Unkown
HY-147136 MYF-03-176 Inhibitor 99.72% Unkown
HY-P2244 YAP-TEAD-IN-1 Inhibitor 99.68% Unkown
HY-174275 TEAD1/3/4-IN-1 Inhibitor 99.04% Unkown
HY-P2244A YAP-TEAD-IN-1 TFA Inhibitor 99.99% Unkown
HY-147208 MSC-4106 Inhibitor 99.87% Unkown
HY-147088 TEAD-IN-2 Inhibitor 98.14% Unkown
HY-161569 TEAD-IN-11 Inhibitor 99.82% Unkown
HY-186117 KG-FP-003 Degrader / Unkown
HY-147209 DC-TEAD3in03 Inhibitor / Unkown
HY-161443 TEAD-IN-9 Inhibitor / Unkown
HY-161568 TEAD-IN-10 Inhibitor / Unkown
HY-168506 MSC-1254 Inhibitor / Unkown
HY-170764 M3686 Inhibitor / Unkown
HY-173139 TEAD-IN-19 Inhibitor / Unkown
HY-181530 IAP ligand 6 Ligand / Unkown
HY-181532 IAP ligand 8 Ligand / Unkown
HY-181533 IAP ligand 9 Ligand / Unkown
HY-181534 PROTAC TEAD1/IAP degrader-1 Degrader / Unkown
HY-181536 TEAD ligand 2 Ligand / Unkown
HY-181537 PROTAC TEAD1/IAP degrader-2 / Unkown
HY-181590 PROTAC TEAD1/IAP degrader-3 Degrader / Unkown
HY-181591 IAP ligand 10 / Unkown
HY-181592 TEAD ligand 4 Degrader / Unkown
HY-181593 IAP ligand-Linker Conjugate 2 / Unkown
HY-181594 PROTAC TEAD/IAP degrader-1 Degrader / Unkown
HY-182672 VT101 Inhibitor / Unkown
HY-182673 VT102 Inhibitor / Unkown
HY-183728 LC-TEAD01 Inhibitor / Unkown
HY-183753 LC-TD-05 / Unkown
HY-184225 PROTAC TEAD degrader-3 Degrader / Unkown
HY-185230 HC278 Degrader / Unkown
HY-186021 PROTAC TEAD degrader-2 Degrader / Unkown
HY-186022 YAP/TAZ-TEAD-IN-3 Inhibitor / Unkown
HY-186023 TEAD ligand-Linker Conjugate 1 / Unkown
HY-186118 TEAD ligand 6 Ligand / Unkown
HY-187180 GNE-8025 / Unkown
HY-187181 GNE-2181 Inhibitor / Unkown
HY-RS14342 TEAD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W803227 1-(2-Chloro-acetyl)-piperazine / Unkown
HY-168505 MSC-5046 Inhibitor / Unkown
HY-169316 YAP/TAZ inhibitor-4 Inhibitor / Unkown
HY-181535 IAP ligand-Linker Conjugate 1 Ligand / Unkown
HY-181538 TEAD ligand 3 Ligand / Unkown
HY-181539 TEAD ligand-Linker Conjugate 2 / Unkown
HY-181607 TEAD ligand-Linker Conjugate 3 Degrader / Unkown
HY-208734 YAP1/TEAD negative control-1 / Unkown
HY-RS17084 Tead1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23528 Tead1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tead1 NCBI NCBI:7003