GABARAPL1 - GABA type A receptor associated protein like 1 Gene
Also Known as ATG8; GEC1; APG8L; ATG8B; ATG8L; APG8-LIKE
Species: Homo sapiens
About GABARAPL1
This gene has 19 transcripts (splice variants), 202 orthologues and 6 paralogues. Broad expression in brain (RPKM 136.2), kidney (RPKM 101.2) and 23 other tissues.
Summary
Enables Tat protein binding activity and ubiquitin protein Ligase binding activity. Predicted to be involved in autophagosome assembly; Autophagy of mitochondrion; and cellular response to nitrogen starvation. Located in autophagosome. Colocalizes with mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
GABARAPL1 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001363598.2 | NP_001350527.1 | gamma-aminobutyric acid receptor-associated protein-like 1 isoform 1 |
| NM_031412.4 | NP_113600.1 | gamma-aminobutyric acid receptor-associated protein-like 1 isoform 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables Tat protein binding |
IPI
IPI: Inferred from physical interaction
|
22354992 | GOA |
| enables phospholipid binding |
IDA
IDA: Inferred from direct assay
|
20404487 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9892355 | GOA |
| enables ubiquitin protein ligase binding |
IPI
IPI: Inferred from physical interaction
|
25127057 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in autophagosome |
IDA
IDA: Inferred from direct assay
|
15292400 | GOA |
| colocalizes with mitochondrion |
IGI
IGI: Inferred from genetic interaction
|
20200478 | GOA |
GABARAPL1 Protein Structure
Atg8: Autophagy protein Atg8 ubiquitin like (14 - 116)
- 0
- 100
- 117 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
gamma-aminobutyric acid receptor-associated protein-like 1 |
|
GABARAPL1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
GABARAPL1 | Q9H0R8 | KRTAP10-9 | Homo sapiens | P60411 | 25416956 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | RETREG3 | Homo sapiens | Q86VR2 | 25416956 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | RETREG3 | Homo sapiens | Q86VR2 | 29892012 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | RETREG3 | Homo sapiens | Q86VR2 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | RETREG3 | Homo sapiens | Q86VR2 | 25416956 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TBC1D5 | Homo sapiens | B9A6K1 | 25416956 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | AHNAK2 | Homo sapiens | Q8IVF2-2 | 25416956 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | NEK9 | Homo sapiens | Q8TD19 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TBC1D15 | Homo sapiens | Q8TC07 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | OSBPL3 | Homo sapiens | Q9H4L5 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | OSBPL3 | Homo sapiens | Q9H4L5 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | OSBPL3 | Homo sapiens | Q9H4L5 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | STRN3 | Homo sapiens | Q13033-2 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | STRN3 | Homo sapiens | Q13033-2 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | STRN3 | Homo sapiens | Q13033-2 | 34524948 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | RABGAP1 | Homo sapiens | Q9Y3P9 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | RABGAP1 | Homo sapiens | Q9Y3P9 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | UMAD1 | Homo sapiens | C9J7I0 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | UMAD1 | Homo sapiens | C9J7I0 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | BSCL2 | Homo sapiens | J3KQ12 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | BSCL2 | Homo sapiens | J3KQ12 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | CLINT1 | Homo sapiens | Q14677 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TBC1D25 | Homo sapiens | Q3MII6 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TBC1D25 | Homo sapiens | Q3MII6 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | SCYL3 | Homo sapiens | Q8IZE3-2 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | SCYL3 | Homo sapiens | Q8IZE3-2 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | SCYL3 | Homo sapiens | Q8IZE3-2 | 34524948 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | NEDD4 | Homo sapiens | P46934-3 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | NEDD4 | Homo sapiens | P46934-3 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | DISC1 | Homo sapiens | Q9NRI5-2 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | DISC1 | Homo sapiens | Q9NRI5-2 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | DISC1 | Homo sapiens | Q9NRI5-2 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | AHNAK2 | Homo sapiens | Q8IVF2-3 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | AHNAK2 | Homo sapiens | Q8IVF2-3 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | NFIA | Homo sapiens | Q12857-2 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | NFIA | Homo sapiens | Q12857-2 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TMEM131 | Homo sapiens | Q0P631 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TMEM131 | Homo sapiens | Q0P631 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | PTPRR | Homo sapiens | Q15256-5 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | PTPRR | Homo sapiens | Q15256-5 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ATG2A | Homo sapiens | Q2TAZ0 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ATG2A | Homo sapiens | Q2TAZ0 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | KBTBD6 | Homo sapiens | Q86V97 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | KBTBD6 | Homo sapiens | Q86V97 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | KBTBD6 | Homo sapiens | Q86V97 | 25684205 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | KBTBD6 | Homo sapiens | Q86V97 | 25684205 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ATG101 | Homo sapiens | Q9BSB4 | 34524948 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | DNAAF4 | Homo sapiens | Q8WXU2 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | FNIP1 | Homo sapiens | Q8TF40 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TECPR2 | Homo sapiens | O15040 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | NSMAF | Homo sapiens | Q92636 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | STBD1 | Homo sapiens | O95210 | 34524948 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | STBD1 | Homo sapiens | O95210 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TBC1D2B | Homo sapiens | Q9UPU7 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ATG4A | Homo sapiens | Q8WYN0 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ATG4A | Homo sapiens | Q8WYN0 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ATG4A | Homo sapiens | Q8WYN0 | 25416956 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ATG4A | Homo sapiens | Q8WYN0 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ATG4A | Homo sapiens | Q8WYN0 | 25416956 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | SQSTM1 | Homo sapiens | Q13501 | 39009827 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | SQSTM1 | Homo sapiens | Q13501 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | SQSTM1 | Homo sapiens | Q13501 | 39009827 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | SQSTM1 | Homo sapiens | Q13501 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | SQSTM1 | Homo sapiens | Q13501 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | SQSTM1 | Homo sapiens | Q13501 | 37219487 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | NIPSNAP2 | Homo sapiens | O75323 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | NIPSNAP2 | Homo sapiens | O75323 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | DYNLL1 | Homo sapiens | P63167 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | DYNLL1 | Homo sapiens | P63167 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | SAFB2 | Homo sapiens | Q14151 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | SAFB2 | Homo sapiens | Q14151 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | IPO5 | Homo sapiens | O00410 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | HADHB | Homo sapiens | P55084 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | RCN2 | Homo sapiens | Q14257 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | RCN2 | Homo sapiens | Q14257 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | RCN2 | Homo sapiens | Q14257 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | HADHA | Homo sapiens | P40939 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TNIP1 | Homo sapiens | Q15025 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TNIP1 | Homo sapiens | Q15025 | 25416956 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TNIP1 | Homo sapiens | Q15025 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TNIP1 | Homo sapiens | Q15025 | 31515488 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TNIP1 | Homo sapiens | Q15025 | 25416956 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | KBTBD7 | Homo sapiens | Q8WVZ9 | 25416956 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | KBTBD7 | Homo sapiens | Q8WVZ9 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | KBTBD7 | Homo sapiens | Q8WVZ9 | 25416956 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | KBTBD7 | Homo sapiens | Q8WVZ9 | 25684205 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | PRKAR1A | Homo sapiens | P10644 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TAX1BP1 | Homo sapiens | Q86VP1 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TAX1BP1 | Homo sapiens | Q86VP1 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | PSMB4 | Homo sapiens | P28070 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | PSMB4 | Homo sapiens | P28070 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ATG4B | Homo sapiens | Q9Y4P1 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ATG4B | Homo sapiens | Q9Y4P1 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ATG4B | Homo sapiens | Q9Y4P1 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ATG4B | Homo sapiens | Q9Y4P1 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | BSDC1 | Homo sapiens | Q9NW68 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | BSDC1 | Homo sapiens | Q9NW68 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | BSDC1 | Homo sapiens | Q9NW68 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ZBTB22 | Homo sapiens | O15209 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ZBTB22 | Homo sapiens | O15209 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | NEDD4 | Homo sapiens | P46934 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | CALCOCO2 | Homo sapiens | Q13137 | 25416956 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | CALCOCO2 | Homo sapiens | Q13137 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | CALCOCO2 | Homo sapiens | Q13137 | 25416956 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | CALCOCO2 | Homo sapiens | Q13137 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | KXD1 | Homo sapiens | Q9BQD3 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | KXD1 | Homo sapiens | Q9BQD3 | 21516116 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | KXD1 | Homo sapiens | Q9BQD3 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | PBXIP1 | Homo sapiens | Q96AQ6 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | PBXIP1 | Homo sapiens | Q96AQ6 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | THAP7 | Homo sapiens | Q9BT49 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | THAP7 | Homo sapiens | Q9BT49 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TBC1D5 | Homo sapiens | Q92609 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TBC1D5 | Homo sapiens | Q92609 | 34524948 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TBC1D5 | Homo sapiens | Q92609 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | NBR1 | Homo sapiens | Q14596 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | NBR1 | Homo sapiens | Q14596 | 19250911 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | UBA5 | Homo sapiens | Q9GZZ9 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | CALCOCO1 | Homo sapiens | Q9P1Z2 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | CALCOCO1 | Homo sapiens | Q9P1Z2 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | CALCOCO1 | Homo sapiens | Q9P1Z2 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | NCOA7 | Homo sapiens | Q8NI08 | 34524948 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | NCOA7 | Homo sapiens | Q8NI08 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | BNIP3L | Homo sapiens | O60238 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | BNIP3L | Homo sapiens | O60238 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | MLX | Homo sapiens | Q9UH92-3 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ULK1 | Homo sapiens | O75385 | 34524948 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | OPRK1 | Homo sapiens | P41145 | 16431922 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | OPRK1 | Homo sapiens | P41145 | 16431922 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ATG7 | Homo sapiens | O95352 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | ATG3 | Homo sapiens | Q9NT62 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | STK3 | Homo sapiens | Q13188 | 20562859 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TP53INP1 | Homo sapiens | Q96A56 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TP53INP1 | Homo sapiens | Q96A56 | 32296183 | |
|
Intra
|
GABARAPL1 | Q9H0R8 | TP53INP1 | Homo sapiens | Q96A56 | 32296183 |
Recombinant GABARAPL1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70913 | GABARAPL1/GEC-1 Protein, Human (His) | Q9H0R8 (M1-K117) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Granulomatous Amebic Encephalitis |
|
|
| Primary Amebic Meningoencephalitis |
|
|
| Warburg Micro Syndrome 3 |
|
|
| Warburg Micro Syndrome 2 |
|
|
| Retinitis Pigmentosa |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Zellweger Syndrome |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | GABARAPL1 | VGNC | VGNC:99929 |
| Mus musculus | GABARAPL1 | MGD | MGI:1914980 |
| Canis familiaris | GABARAPL1 | VGNC | VGNC:57447 |
| Rattus norvegicus | GABARAPL1 | RGD | RGD:1596143 |
| Felis catus | GABARAPL1 | VGNC | VGNC:84022 |
| Bos taurus | GABARAPL1 | VGNC | VGNC:56201 |
| Others | GABARAPL1 | NCBI |