Pde10a - phosphodiesterase 10A Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23984

About Pde10a

Chromosome 17: 8,744,204-9,205,480 forward strand.GRCm39:CM001010.3

This gene has 14 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 27 phenotypes. Biased expression in CNS E18 (RPKM 7.5), cortex adult (RPKM 4.9) and 13 other tissues.

Summary

Enables 3',5'-cyclic-nucleotide phosphodiesterase activity. Acts upstream of or within regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of protein kinase A signaling. Predicted to be located in membrane and perikaryon. Is expressed in alimentary system; cardiovascular system; nervous system; and sensory organ. Orthologous to human PDE10A (phosphodiesterase 10A). [provided by Alliance of Genome Resources, Apr 2022]

Pde10a Products (3)

mRNA Protein Name
NM_001290707.1 NP_001277636.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1
NM_001347321.1 NP_001334250.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3
NM_011866.2 NP_035996.2 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IDA
IDA: Inferred from direct assay
10359840 MGI
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IMP
IMP: Inferred from mutant phenotype
27058446 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18923023 MGI
acts upstream of or within regulation of cAMP/PKA signal transduction IMP
IMP: Inferred from mutant phenotype
18923023 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
31171447 MGI
is active in synapse IDA
IDA: Inferred from direct assay
31171447 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pde10a Protein Structure

GAF

GAF: pfam01590 (100 - 243)

GAF

GAF: smart00065 (276 - 431)

PDEase_I

PDEase_I: pfam00233 (523 - 754)

  • 0
  • 200
  • 400
  • 600
  • 796 a.a.
Protein Preferred Names Protein Names

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

  • dual-substrate cAMP and cGMP, cyclic nucleotide phosphodiesterase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-50098 Mardepodect Inhibitor 99.78% Phase 2
HY-12472 Balipodect Inhibitor 99.47% Phase 2
HY-14550 TP-10 Inhibitor 99.95% Phase 2
HY-153093 Elpipodect Inhibitor 98.95% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2
HY-152838 Gemlapodect Inhibitor / Phase 2
HY-12913 AMG 579 Inhibitor 98.95% Phase 1
HY-148954 PBF-999 Antagonist 98.89% Phase 1
HY-116253 JNJ-42396302 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (31)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50098A Mardepodect hydrochloride Inhibitor 99.94% Unkown
HY-W003486 5,7-Dichloropyrazolo[1,5-a]pyrimidine Inhibitor 99.69% Unkown
HY-135848 N-Methylbenzamide Inhibitor 99.93% Unkown
HY-18078 PQ-10 Inhibitor 99.41% Unkown
HY-131973 PDE10A-IN-2 hydrochloride Inhibitor 98.43% Unkown
HY-117604 THPP-1 Inhibitor 99.52% Unkown
HY-182638 CPL500036 / Unkown
HY-112704 PDE5-IN-2 Inhibitor / Unkown
HY-10030 Mardepodect succinate / Unkown
HY-10568 TC-E 5005 Inhibitor / Unkown
HY-120022 THPP-2 Inhibitor / Unkown
HY-120291 ASP9436 Inhibitor / Unkown
HY-120945 PDE10A-IN-1 Inhibitor / Unkown
HY-123154 PDE10A-IN-4 Inhibitor / Unkown
HY-123446 JNJ-42259152 / Unkown
HY-123743 JNJ-42314415 Inhibitor / Unkown
HY-14458 SCH-1518291 Inhibitor / Unkown
HY-153093A (1R,2R)-Elpipodect Inhibitor / Unkown
HY-158237 PDE10A-IN-3 Inhibitor / Unkown
HY-160111 PDM-042 Inhibitor / Unkown
HY-161663 Phosphodiesterase-IN-2 Inhibitor / Unkown
HY-173360 PDE10A-IN-5 Inhibitor / Unkown
HY-178987 BJH-86 Inhibitor / Unkown
HY-179645 Phosphodiesterase-IN-5 / Unkown
HY-18037 AMG-7980 / Unkown
HY-RS10199 PDE10A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10200 Pde10a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10201 Pde10a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117838 Phosphodiesterase 10-IN-2 Inhibitor / Unkown
HY-124392 AMG580 Antagonist / Unkown
HY-169773 Mardepodect precursor Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde10a NCBI NCBI:10846