Ccl2 - C-C motif chemokine ligand 2 Gene

Also Known as MCP-1; Scya2; Sigje

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24770

Summary

Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and leukocyte migration. Located in several cellular components, including perikaryon; perinuclear region of cytoplasm; and rough endoplasmic reticulum. Colocalizes with C-fiber. Used to study several diseases, including artery disease (multiple); diabetic angiopathy; interstitial lung disease (multiple); kidney disease (multiple); and pancreatitis (multiple). Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); lung disease (multiple); non-alcoholic fatty liver disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system Cancer (multiple); and tuberculosis (multiple). Orthologous to human CCL2 (C-C motif chemokine ligand 2). [provided by Alliance of Genome Resources, Apr 2022]

Ccl2 Products (1)

mRNA Protein Name
NM_031530.1 NP_113718.1 C-C motif chemokine 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemokine activity IDA
IDA: Inferred from direct assay
11104723 RGD
enables heparin binding IPI
IPI: Inferred from physical interaction
16127145 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
19420110 RGD
involved in cellular response to ATP IEP
IEP: Inferred from expression pattern
19125410 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
14512159 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
17237237 RGD
involved in cellular response to fatty acid IEP
IEP: Inferred from expression pattern
14656734 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
26222724 RGD
involved in cellular response to high density lipoprotein particle stimulus IEP
IEP: Inferred from expression pattern
18483405 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
17180354 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
14512159 RGD
involved in cellular response to interleukin-6 IEP
IEP: Inferred from expression pattern
8921263 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
8921263 RGD
involved in cellular response to lipoprotein particle stimulus IEP
IEP: Inferred from expression pattern
11473635 RGD
involved in cellular response to macrophage colony-stimulating factor stimulus IEP
IEP: Inferred from expression pattern
8921263 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: Inferred from expression pattern
7589574 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
11274229 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
14512159 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
14512159 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16331110 RGD
involved in chemokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18584881 RGD
involved in chronic inflammatory response IEP
IEP: Inferred from expression pattern
15104336 RGD
involved in cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
16174730 RGD
involved in glial cell migration IMP
IMP: Inferred from mutant phenotype
23010641 RGD
involved in intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
15978006 RGD
involved in leukocyte migration involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
8774140 RGD
involved in lymphocyte chemotaxis IDA
IDA: Inferred from direct assay
11104723 RGD
involved in macrophage chemotaxis IDA
IDA: Inferred from direct assay
16127145 RGD
involved in mammary gland involution IEP
IEP: Inferred from expression pattern
20110414 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
8788206 RGD
involved in maternal process involved in parturition IEP
IEP: Inferred from expression pattern
18606702 RGD
involved in neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
16127145 RGD
involved in positive regulation of NMDA glutamate receptor activity IGI
IGI: Inferred from genetic interaction
27094552 RGD
involved in positive regulation of cell adhesion IDA
IDA: Inferred from direct assay
8103296 RGD
involved in positive regulation of cell-cell adhesion IDA
IDA: Inferred from direct assay
10225970 RGD
involved in positive regulation of cellular extravasation IDA
IDA: Inferred from direct assay
10225970 RGD
involved in positive regulation of collagen biosynthetic process IDA
IDA: Inferred from direct assay
8663511 RGD
involved in positive regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
14693680 RGD
involved in positive regulation of leukocyte mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
8103296 RGD
involved in positive regulation of leukocyte migration IDA
IDA: Inferred from direct assay
7943176 RGD
involved in positive regulation of leukocyte migration IMP
IMP: Inferred from mutant phenotype
14512159 RGD
involved in positive regulation of macrophage chemotaxis IDA
IDA: Inferred from direct assay
9430491 RGD
involved in positive regulation of monocyte chemotaxis IDA
IDA: Inferred from direct assay
1387671 RGD
involved in positive regulation of protein targeting to membrane IDA
IDA: Inferred from direct assay
22222817 RGD
involved in positive regulation of synaptic transmission IDA
IDA: Inferred from direct assay
18584881 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
24826069 RGD
involved in positive regulation of wound healing IMP
IMP: Inferred from mutant phenotype
12831234 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
18797164 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
18475188 RGD
involved in response to cyclosporin A IEP
IEP: Inferred from expression pattern
15059785 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17935147 RGD
involved in response to gamma radiation IEP
IEP: Inferred from expression pattern
19084914 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
19210118 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
19278353 RGD
involved in response to isolation stress IEP
IEP: Inferred from expression pattern
33411841 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19111613 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
18606702 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
18606702 RGD
involved in response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
15855648 RGD
involved in response to vitamin B3 IEP
IEP: Inferred from expression pattern
19420110 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18388116 RGD
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14505427 RGD
involved in vascular endothelial growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14693680 RGD
Cellular Component GO Annotation Evidence References Source
located in C-fiber IDA
IDA: Inferred from direct assay
18076762 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
19059387 RGD
located in dendrite IDA
IDA: Inferred from direct assay
16025454 RGD
located in endocytic vesicle IDA
IDA: Inferred from direct assay
12080327 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
19060786 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15978006 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
16025454 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
14512159 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-C motif chemokine 2

  • chemokine (C-C motif) ligand 2

  • immediate-early serum-responsive JE protein

  • immediate-early serum-responsive protein JE

  • monocyte chemoattractant protein 1

  • monocyte chemotactic protein 1

  • small inducible cytokine A2

  • small inducible gene JE

Recombinant Ccl2 Proteins

Cat. No. Product Name Accession Purity
HY-P7236 MCP-1/CCL2 Protein, Rat (HEK293, C-His) P14844 (Q24-N148) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0673 Pirfenidone Inhibitor 99.99% Yes
HY-B1322A Amodiaquine 99.92% Unkown
HY-B1322 Amodiaquine dihydrochloride dihydrate 99.97% Unkown
HY-B1203 Fludrocortisone 98.99% Yes
HY-B1322B Amodiaquine dihydrochloride 99.97% Unkown
HY-B0673R Pirfenidone (Standard) Inhibitor 99.97% Unkown
HY-B1076 Medrysone 99.79% Unkown
HY-B1203R Fludrocortisone (Standard) / Unkown

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-B0498 Bindarit Inhibitor 99.59% Phase 3
HY-B0673S1 Deupirfenidone 99.93% Phase 3
HY-165528 Histamine glutarimide Inhibitor / Phase 3
HY-148100A Emapticap pegol sodium Inhibitor 91.38% Phase 2
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99188 Carlumab Inhibitor 97.80% Phase 2
HY-P99450 Avdoralimab Inhibitor 99.25% Phase 2
HY-P99781 Plozalizumab Inhibitor 99.53% Phase 2

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W007376 Indole-3-carboxaldehyde 99.96% Unkown
HY-120501 B022 Inhibitor 99.27% Unkown
HY-115644 BMS-470539 dihydrochloride Agonist 99.85% Unkown
HY-120897 NS-3-008 hydrochloride Inhibitor 99.67% Unkown
HY-160552 244cis 99.67% Unkown
HY-116247 ST247 Agonist 99.88% Unkown
HY-N0444 Rubiadin 99.20% Unkown
HY-B0673S Pirfenidone-d5 Inhibitor 98.88% Unkown
HY-170415 EGR-1-IN-3 Inhibitor 99.13% Unkown
HY-W013675 2-Methoxyhydroquinone Pre-designed Set 99.57% Unkown
HY-NP192 Sericin 0% Unkown
HY-148100 Emapticap pegol Inhibitor 91.38% Unkown
HY-149202 UT-11 Inhibitor 98.25% Unkown
HY-P11553A ECL1i TFA Inhibitor 97.36% Unkown
HY-RS02089 CCL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16514 Ccl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B1203S Fludrocortisone-d5 / Unkown
HY-108554 Q94 hydrochloride Antagonist / Unkown
HY-121896 DSHN Activator / Unkown
HY-144334 CHIKV-IN-3 Inhibitor / Unkown
HY-163655 Glutaminyl Cyclase Inhibitor 6 Inhibitor / Unkown
HY-171680 Anti-CCL2 (Carlumab)-SMCC-DM1 / Unkown
HY-171681 Anti-CCL2 (Carlumab)-SPDB-DM4 / Unkown
HY-171682 Anti-CCL2 (Carlumab)-McMMAF / Unkown
HY-171683 Anti-CCL2 (Carlumab)-VcMMAE / Unkown
HY-171684 Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38 / Unkown
HY-171685 Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA / Unkown
HY-171895 12-Nitrolinoleate / Unkown
HY-173518 SIN 14 / Unkown
HY-176255 TBK1 degrader-4 Inhibitor / Unkown
HY-178926 RAGE406R Inhibitor / Unkown
HY-180831 BRD4 D1-IN-3 Inhibitor / Unkown
HY-185153 MC-VC-PAB-DMEA-PEG2-Duocarmycin SA / Unkown
HY-B1203S1 Fludrocortisone-d2 / Unkown
HY-B1322AS1 Amodiaquine-d10 hydrochloride / Unkown
HY-N3887 Evoxine Inhibitor / Unkown
HY-P11553 ECL1i Inhibitor / Unkown
HY-W104821 Rosolic acid Activator / Unkown
HY-168782 Resolvin D2 n-3 DPA Inhibitor / Unkown
HY-174763 Human CCL2 mRNA / Unkown
HY-177933 mNOX-E36 Inhibitor / Unkown
HY-183423 MK256 Inhibitor / Unkown
HY-RS22945 Ccl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990297 Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) Inhibitor 99.5% Unkown
HY-P99149 Anti-Mouse TNFR2 Antibody (TR75-54.7) Inhibitor 98.864% Unkown
HY-P991280 BMS-981164 Inhibitor 95.36% Unkown
HY-P991208 Flt-3L-Ig (hum/hum) 98% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccl2 NCBI NCBI:6347