Dcc - DCC netrin 1 receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25311

Summary

Enables identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron projection development; and response to amphetamine. Located in growth cone membrane and membrane raft. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; esophageal cancer; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Dcc Products (1)

mRNA	Protein	Name
NM_012841.2	NP_036973.1	netrin receptor DCC precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18585357	RGD
enables netrin receptor activity	IMP IMP: Inferred from mutant phenotype	8861902	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15788770	RGD
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	12840034	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in axon development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in axon guidance	IMP IMP: Inferred from mutant phenotype	8861902	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in corpus callosum development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in optic nerve development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	15811950	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	15737744	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	17996376	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	12840034	RGD
located in growth cone membrane	IDA IDA: Inferred from direct assay	18691385	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
netrin receptor DCC	colorectal tumor suppressor deleted in colorectal carcinoma putative colorectal tumor suppressor tumor suppressor protein DCC

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112306	Ripretinib		98.90%	Yes
HY-136256	Vimseltinib	Inhibitor	99.94%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13024	Rebastinib		99.84%	Phase 2
HY-160699	DCC-3116	Inhibitor	99.84%	Phase 2
HY-B0791	Altiratinib	Inhibitor	99.29%	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Y1092	N,N-Dicyclohexylcarbodiimide(DCC)	Activator	99.75%	Unkown
HY-W074890	Palmitoylglycine	Modulator	99.84%	Unkown
HY-W099632	2-Hexyldecanoic acid		99.71%	Unkown
HY-D2751	BP Fluor 488 cadaverine		98.15%	Unkown
HY-100855	DC_C66	Inhibitor	/	Unkown
HY-13024A	Rebastinib tosylate		/	Unkown
HY-163008	Dicamba-5-aminopentanoic acid		/	Unkown
HY-RS03571	DCC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-157262	Methyl isonicotinate-(CH2)2-COOH		/	Unkown
HY-D2764	Difluorocarboxyfluorescein cadaverine, 5-isomer		/	Unkown
HY-D2765	BP Fluor 405 cadaverine		/	Unkown
HY-D2772	5-TAMRA Cadaverine		/	Unkown
HY-RS17183	Dcc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23634	Dcc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dcc	NCBI	NCBI:1630