HPGDS - hematopoietic prostaglandin D synthase Gene

Also Known as GSTS; PGD2; PGDS; GSTS1; GSTS1-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27306

About HPGDS

Cytogenetic location: 4q22.3 Genomic coordinates (GRCh38): 4:94,298,535-94,342,836 (from NCBI)

This gene has 3 transcripts (splice variants), 134 orthologues and 11 paralogues. Broad expression in placenta (RPKM 12.7), lung (RPKM 6.6) and 16 other tissues.

Summary

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]

HPGDS Products (1)

mRNA	Protein	Name
NM_014485.3	NP_055300.1	hematopoietic prostaglandin D synthase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	12627223	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	12627223	GOA
enables prostaglandin-D synthase activity	IDA IDA: Inferred from direct assay	12627223	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	12627223	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in prostaglandin metabolic process	IDA IDA: Inferred from direct assay	12627223	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HPGDS Protein Structure

GST_N

GST_C

0
100
199 a.a.

Protein Preferred Names	Protein Names
hematopoietic prostaglandin D synthase	GST class-sigma

HPGDS Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HPGDS	O60760	MELTF	Homo sapiens	P08582-2	Y2H Prey Pooling	25416956
Intra	HPGDS	O60760	LIF	Homo sapiens	P15018	Validated Y2H	32296183
Intra	HPGDS	O60760	SIX6OS1	Homo sapiens	Q8N1H7	Y2H Prey Pooling	32296183
Intra	HPGDS	O60760	SIX6OS1	Homo sapiens	Q8N1H7	Y2H Array	32296183
Intra	HPGDS	O60760	SIX6OS1	Homo sapiens	Q8N1H7	Validated Y2H	32296183
Intra	HPGDS	O60760	ABHD17A	Homo sapiens	Q96GS6	Y2H Array	25416956
Intra	HPGDS	O60760	ABHD17A	Homo sapiens	Q96GS6	Y2H Prey Pooling	25416956
Intra	HPGDS	O60760	ARRDC3	Homo sapiens	Q96B67	Validated Y2H	25416956
Intra	HPGDS	O60760	ARRDC3	Homo sapiens	Q96B67	Validated Y2H	32296183
Intra	HPGDS	O60760	ARRDC3	Homo sapiens	Q96B67	Y2H Array	32296183
Intra	HPGDS	O60760	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	25416956
Intra	HPGDS	O60760	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	32296183
Intra	HPGDS	O60760	PDE3B	Homo sapiens	Q13370	Y2H Prey Pooling	32296183
Intra	HPGDS	O60760	PDE3B	Homo sapiens	Q13370	Validated Y2H	32296183
Intra	HPGDS	O60760	PDE3B	Homo sapiens	Q13370	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HPGDS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71036	HPGDS Protein, Human	O60760 (M1-L199)	≥ 95%, as determined by reducing SDS-PAGE.

HPGDS Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81994	Prostaglandin D Synthase Antibody (YA1739)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P81994A	Prostaglandin D Synthase Antibody (YA1739)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
O'Nyong'Nyong Fever	O'Nyong-Nyong Fever O'Nyong-Nyong Mosquito-Borne Viral Fever O'Nyong-Nyong Arthritis Onn - [O'Nyong-Nyong Fever]
Intermediate Malignant Teratoma	Malignant Teratoma, Intermediate Intermediate Immature Teratoma
Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly	Asphyxiating Thoracic Dystrophy 2 SRTD2 Atd2 Jatd Jeune Asphyxiating Thoracic Dystrophy Jeune Syndrome 2
Filarial Elephantiasis	Lymphatic Filariasis Elephantiasis Filariasis Bancroftian Elephantiasis Bancroftian Filarial Chyluria Elephantiasis Of Eyelid Bancroftian Filariasis Elephantitis Malayi Tropical Eosinphilia Wuchereria Bancrofti Infection Wuchereriasis Elephantiasis, Filarial Filarial Elephantiases Infection By Wuchereria Bancrofti Filarial Lymphangitis Tropical Elephantiasis Filarial Chylocele
Fascioliasis	Fasciola Hepatica Infection Infection By Fasciola Sheep Liver Fluke Infection Liver Flukes Fasciola Infestation Sheep Liver Fluke Disease Liver Fluke Infestation Liver Flukes Nos Liver Fluke Infection Liver Fluke Disease
Parasitic Ectoparasitic Infectious Disease	Ectoparasitic Infestations Ectoparasitism
Skin Papilloma	Cutaneous Papilloma Papilloma Of Skin Papilloma Skin
Inflammatory Bowel Disease 16	IBD16 Inflammatory Bowel Disease 16, Susceptibility To
Methylmalonic Aciduria And Homocystinuria, Cbld Type	Homocystinuria, Cbld Type, Variant 1 Methylmalonic Aciduria And Homocystinuria Type Cbld Vitamin B12-Responsive Methylmalonic Acidemia, Type Cbldv2 MAHCD Methylmalonic Acidemia And Homocystinuria, Cbld Type Methylmalonic Aciduria, Cblh Type, Formerly Methylmalonic Acidemia, Cblh Type, Formerly Methylmalonic Aciduria, Cbld Type, Variant 2 Cobalamin D Deficiency Methylcobalamin Deficiency Type Cbldv1 Functional Methionine Synthase Deficiency Type Cbldv1 Vitamin B12-Responsive Methylmalonic Aciduria, Type Cbldv2 Methylmalonic Acidemia With Homocystinuria, Type Cbld Cbld Defect Cobalamin D Defect Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cbld Methylmalonic Aciduria With Homocystinuria, Type Cbld Homocystinuria Cbld Variant 1 Methylmalonic Acidemia And Homocystinuria Cbld Type Methylmalonic Aciduria And Homocystinuria Cbld-Combined Methylmalonic Aciduria And Homocystinuria Cbld Original Methylmalonic Aciduria Cbld Variant 2 Aciduria, Methylmalonic, And Homocystinuria, Cbld Type
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-116449	2-Benzoylthiophene		99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108259	HQL-79	Inhibitor	99.89%	Unkown
HY-10439	HPGDS inhibitor 1	Inhibitor	99.42%	Unkown
HY-12791	hPGDS-IN-1	Inhibitor	99.92%	Unkown
HY-139972	PROTAC(H-PGDS)-7		99.42%	Unkown
HY-110167	TFC 007	Inhibitor	98.01%	Unkown
HY-126134	HPGDS inhibitor 2	Inhibitor	99.70%	Unkown
HY-146662	HPGDS inhibitor 3	Inhibitor	/	Unkown
HY-157577	PROTAC(H-PGDS)-8	Degrader	/	Unkown
HY-RS06338	HPGD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06339	Hpgd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06340	Hpgd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06341	HPGDS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120581	ML388	Inhibitor	/	Unkown
HY-139171	F092	Inhibitor	99.79%	Unkown
HY-RS17229	Hpgds Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23682	Hpgds Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HPGDS	VGNC	VGNC:54312
Felis catus	HPGDS	VGNC	VGNC:62837
Macaca mulatta	HPGDS	VGNC	VGNC:73410
Mus musculus	HPGDS	MGD	MGI:1859384
Bos taurus	HPGDS	VGNC	VGNC:29941
Rattus norvegicus	HPGDS	RGD	RGD:69251
Others	HPGDS	NCBI