Tnks - tankyrase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 290794

About Tnks

Primary_assembly 16: 57,225,094-57,366,260 forward strand.mRatBN7.2:CM026989.1

This gene has 2 transcripts (splice variants), 279 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in Kidney (RPKM 111.8), Lung (RPKM 14.4) and 9 other tissues.

Summary

Predicted to enable histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Involved in cellular response to nutrient. Predicted to be located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNKS (tankyrase). [provided by Alliance of Genome Resources, Apr 2022]

Tnks Products (1)

mRNA Protein Name
NM_001106084.2 NP_001099554.2 poly [ADP-ribose] polymerase tankyrase-1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to nutrient IEP
IEP: Inferred from expression pattern
25876076 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tnks Protein Structure

PTZ00322

PTZ00322: cl31426 (166 - 258)

ANK

ANK: sd00045 (207 - 235)

PHA02876

PHA02876: cl31517 (220 - 605)

ANK

ANK: sd00045 (237 - 268)

ANK

ANK: sd00045 (270 - 301)

ANK

ANK: sd00045 (360 - 388)

ANK

ANK: sd00045 (390 - 421)

ANK

ANK: sd00045 (423 - 454)

ANK

ANK: sd00045 (512 - 544)

ANK

ANK: sd00045 (546 - 577)

ANK

ANK: sd00045 (579 - 608)

PHA03095

PHA03095: cl33707 (641 - 965)

ANK

ANK: sd00045 (675 - 703)

ANK

ANK: sd00045 (705 - 736)

ANK

ANK: sd00045 (738 - 769)

ANK

ANK: sd00045 (825 - 856)

ANK

ANK: sd00045 (858 - 889)

ANK

ANK: sd00045 (891 - 922)

SAM_tankyrase1,2

SAM_tankyrase1,2: cd09524 (1013 - 1078)

tankyrase_like

tankyrase_like: cd01438 (1080 - 1302)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1317 a.a.
Protein Preferred Names Protein Names

poly [ADP-ribose] polymerase tankyrase-1

  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

  • tankyrase-1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108845 Tenecteplase Inhibitor 95.00% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12418 Stenoparib Inhibitor 98.0% Phase 2
HY-147245 Basroparib Inhibitor 98.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (68)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-16910 WIKI4 Inhibitor 99.93% Unkown
HY-14443 XMD8-92 Inhibitor 99.48% Unkown
HY-13990 NVP-TNKS656 99.68% Unkown
HY-12438 G007-LK Inhibitor 99.24% Unkown
HY-13968 JW 55 Inhibitor 99.83% Unkown
HY-145267 OM-153 Inhibitor 99.30% Unkown
HY-123851 MSC2504877 Inhibitor 99.25% Unkown
HY-12975 AZ6102 Inhibitor 99.53% Unkown
HY-147316 TP-5801 Inhibitor 98.55% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-15811 XMD8-87 Inhibitor 99.57% Unkown
HY-15800A CZC-25146 Inhibitor 99.10% Unkown
HY-19351 MN-64 Inhibitor 99.61% Unkown
HY-101243 XMD16-5 Inhibitor 98.20% Unkown
HY-148061 DB1113 99.86% Unkown
HY-U00422 K-756 Inhibitor 99.25% Unkown
HY-148063 DB0614 96.07% Unkown
HY-153996 CT1113 99.61% Unkown
HY-126248 Tankyrase-IN-2 99.06% Unkown
HY-147316A TP-5801 TFA Inhibitor 99.55% Unkown
HY-147886 PARP1-IN-11 Inhibitor 99.42% Unkown
HY-121719 TIQ-A Inhibitor 99.85% Unkown
HY-156332 TNKS-2-IN-2 Inhibitor 99.47% Unkown
HY-164478 G-631 Inhibitor 99.88% Unkown
HY-12577 TNKS1/2-IN-1 Inhibitor 99.24% Unkown
HY-143338 ART-IN-1 Inhibitor 98.91% Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 98.66% Unkown
HY-173349 TDI-012804 Inhibitor / Unkown
HY-23338 TNKS-2-IN-1 Inhibitor 95.03% Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-108516 TC-E 5001 Inhibitor / Unkown
HY-114943 TNKS-IN-1 Inhibitor 99.55% Unkown
HY-117700 TNKS-IN-2 Inhibitor / Unkown
HY-12601 TNKS 22 Inhibitor / Unkown
HY-12602 TNKS-IN-4 Inhibitor / Unkown
HY-13990G NVP-TNKS656 (GMP) / Unkown
HY-145111 TNK2-IN-1 Inhibitor / Unkown
HY-152197 Tankyrase-IN-3 Inhibitor / Unkown
HY-152198 Tankyrase-IN-4 Inhibitor / Unkown
HY-153259 TNKS1/2-IN-2 Inhibitor / Unkown
HY-155246 PARP1-IN-15 / Unkown
HY-167762 TNKS-2-IN-4 Inhibitor / Unkown
HY-172747 TNKS-2-IN-3 Inhibitor / Unkown
HY-180926 PARP10-IN-4 Inhibitor / Unkown
HY-181752 FGFR3-IN-12 / Unkown
HY-E70868 TNK1 Recombinant Human Active Protein Kinase / Unkown
HY-RS14837 TNK1 Human Pre-designed siRNA Set A / Unkown
HY-RS14838 TNK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14839 TNKS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14840 Tnks Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14841 Tnks Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14842 TNKS1BP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14843 TNKS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14844 Tnks2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14845 TNKS2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W294889 OUL245 Inhibitor / Unkown
HY-10893 TNK-651 Inhibitor / Unkown
HY-118731 TNK-6123 Activator / Unkown
HY-153332 Tankyrase-IN-5 Inhibitor / Unkown
HY-15800 CZC-25146 hydrochloride Inhibitor / Unkown
HY-168925 EXQ-2d Inhibitor / Unkown
HY-173480 TNKS-IN-3 Inhibitor / Unkown
HY-180867 TNKS modulator-1 / Unkown
HY-RS16928 Tnk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18502 Tnk1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS23371 Tnk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24984 Tnk1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnks NCBI NCBI:8658