Bmp2 - bone morphogenetic protein 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29373

Summary

Enables growth factor activity; identical protein binding activity; and protein domain specific binding activity. Involved in several processes, including BMP signaling pathway; cellular response to mechanical stimulus; and response to retinoic acid. Acts upstream of or within positive regulation of neurogenesis and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; extracellular space; and vesicle. Part of protein-containing complex. Human ortholog(s) of this gene implicated in bone disease (multiple); hemochromatosis type 1; otosclerosis; prostate cancer; and tooth agenesis. Orthologous to human BMP2 (Bone Morphogenetic Protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Bmp2 Products (1)

mRNA Protein Name
NM_017178.2 NP_058874.2 bone morphogenetic protein 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables growth factor activity IDA
IDA: Inferred from direct assay
12398941 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
12871556 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
12871556 RGD
Biological Process GO Annotation Evidence References Source
involved in BMP signaling pathway IDA
IDA: Inferred from direct assay
12398941 RGD
involved in cardiac muscle hypertrophy in response to stress IMP
IMP: Inferred from mutant phenotype
26873969 RGD
involved in cellular response to BMP stimulus IEP
IEP: Inferred from expression pattern
9246083 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
20877159 RGD
involved in ovulation cycle IEP
IEP: Inferred from expression pattern
15283681 RGD
acts upstream of or within positive regulation of neurogenesis IDA
IDA: Inferred from direct assay
8616889 RGD
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8616889 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
10404008 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
8385738 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
18758911 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12871556 RGD
located in vesicle IDA
IDA: Inferred from direct assay
18758911 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bone morphogenetic protein 2

  • BMP-2

  • BMP-2A

  • bone morphogenetic protein 2A

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100009 Ufenamate Inhibitor 99.89% Unkown

Pre-clinical Phase

Bioactive Molecules (41)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126675A AS2863619 98.02% Unkown
HY-16712 LDN-214117 Inhibitor 99.54% Unkown
HY-P0254 Kisspeptin-10, human 99.86% Unkown
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-N0265 Asperosaponin VI Inhibitor 99.62% Unkown
HY-N0316 Mollugin 99.79% Unkown
HY-N2375 L-Quebrachitol Activator 99.51% Unkown
HY-P5832 BMP2-derived peptide Activator 98.04% Unkown
HY-126675 AS2863619 free base 99.87% Unkown
HY-123940 SGC-AAK1-1 Inhibitor 98.47% Unkown
HY-N1461 Dihydrodaidzein 99.38% Unkown
HY-107245 Segetalin B 99.9% Unkown
HY-P0254A Kisspeptin-10, human TFA 99.56% Unkown
HY-101290A BMT-090605 hydrochloride Inhibitor 98.76% Unkown
HY-120179 LP-922761 98.21% Unkown
HY-142042 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles Inhibitor 99.84% Unkown
HY-Y1123 2-Aminoacetamide hydrochloride Activator 99.89% Unkown
HY-158203 BMP agonist 2 Agonist 99.26% Unkown
HY-N8920 Syringetin 99.42% Unkown
HY-135871 BMT-124110 99.15% Unkown
HY-162653 SGC-CDKL2/AAK1/BMP2K-1 98.55% Unkown
HY-173149 CDD-2789 Inhibitor / Unkown
HY-N0946 (-)-Pinoresinol 4-O-glucoside Inhibitor 98.0% Unkown
HY-120179A LP-922761 hydrate 98.0% Unkown
HY-135871A BMT-124110 formic Inhibitor / Unkown
HY-N8261 Amicoumacin B 98.8% Unkown
HY-RS01536 BMP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01537 BMP2K Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181293 PROTAC AAK1 degrader-1 Degrader / Unkown
HY-N0265R Asperosaponin VI (Standard) Inhibitor 99.46% Unkown
HY-RS17130 Bmp2k Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W190842 m-PEG2-NHS ester 98.0% Unkown
HY-101290 BMT-090605 Inhibitor 98.27% Unkown
HY-121025 BUR1 Inhibitor 99.65% Unkown
HY-126675G AS2863619 (GMP) / Unkown
HY-N16118 Asperosaponin V Modulator / Unkown
HY-N2682B Dehydrodiconiferyl alcohol Agonist 98.32% Unkown
HY-RS01553 Bmpr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16626 Bmp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23061 Bmp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23575 Bmp2k Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmp2 NCBI NCBI:650