BMP2 - bone morphogenetic protein 2 Gene

Also Known as BDA2; BMP2A; SSFSC; SSFSC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 650

About BMP2

Cytogenetic location: 20p12.3 Genomic coordinates (GRCh38): 20:6,767,686-6,780,246 (from NCBI)

This gene has 1 transcript (splice variant), 215 orthologues, 31 paralogues and is associated with 6 phenotypes. Broad expression in fat (RPKM 13.9), colon (RPKM 12.1) and 21 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]

BMP2 Products (2)

mRNA	Protein	Name
NM_001200.4	NP_001191.1	bone morphogenetic protein 2 preproprotein
NM_001200.4	NP_001191.1	bone morphogenetic protein 2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables BMP receptor binding	IDA IDA: Inferred from direct assay	7811286	GOA
enables BMP receptor binding	IPI IPI: Inferred from physical interaction	18184661	GOA
enables co-receptor binding	IPI IPI: Inferred from physical interaction	16604073	GOA
enables cytokine activity	IMP IMP: Inferred from mutant phenotype	27860183	GOA
enables growth factor activity	IDA IDA: Inferred from direct assay	22227436	GOA
enables phosphatase activator activity	IDA IDA: Inferred from direct assay	9213002	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8413626	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	22227436	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	16049014	GOA
involved in BMP signaling pathway	IEP IEP: Inferred from expression pattern	16194878	GOA
involved in BMP signaling pathway	IGI IGI: Inferred from genetic interaction	22450430	GOA
acts upstream of or within BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	17472960	GOA
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	17992660	GOA
involved in cardiac epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	18184661	GOA
involved in cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	21311046	GOA
acts upstream of or within cardiocyte differentiation	IDA IDA: Inferred from direct assay	15110716	GOA
involved in cardiocyte differentiation	IMP IMP: Inferred from mutant phenotype	19736317	GOA
involved in cellular response to BMP stimulus	IMP IMP: Inferred from mutant phenotype	18326817	GOA
involved in chondrocyte differentiation	IDA IDA: Inferred from direct assay	16194878	GOA
involved in endodermal-mesodermal cell signaling	IDA IDA: Inferred from direct assay	19736317	GOA
acts upstream of or within epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	15110716	GOA
involved in epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	18184661	GOA
involved in heart development	IDA IDA: Inferred from direct assay	18545679	GOA
involved in heart induction	IDA IDA: Inferred from direct assay	19736317	GOA
involved in lung vasculature development	IMP IMP: Inferred from mutant phenotype	17992660	GOA
involved in mesenchymal cell differentiation	IDA IDA: Inferred from direct assay	9693150	GOA
involved in mesenchyme development	IMP IMP: Inferred from mutant phenotype	20890042	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15254224	GOA
acts upstream of negative regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	18382765	GOA
involved in negative regulation of aldosterone biosynthetic process	IDA IDA: Inferred from direct assay	19584291	GOA
involved in negative regulation of calcium-independent cell-cell adhesion	IDA IDA: Inferred from direct assay	16194878	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	18545679	GOA
involved in negative regulation of canonical Wnt signaling pathway	IEP IEP: Inferred from expression pattern	17202865	GOA
involved in negative regulation of cardiac muscle cell differentiation	IDA IDA: Inferred from direct assay	18545679	GOA
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	11502704	GOA
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	9187146	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19584291	GOA
involved in negative regulation of cortisol biosynthetic process	IDA IDA: Inferred from direct assay	19584291	GOA
involved in negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	23399447	GOA
acts upstream of negative regulation of gene expression	IDA IDA: Inferred from direct assay	23399447	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	28124060	GOA
involved in negative regulation of insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	19584291	GOA
involved in negative regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	18382765	GOA
involved in negative regulation of smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	28467929	GOA
involved in negative regulation of steroid biosynthetic process	IDA IDA: Inferred from direct assay	19584291	GOA
acts upstream of negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19736317	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9187146	GOA
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway	IGI IGI: Inferred from genetic interaction	28467929	GOA
acts upstream of or within osteoblast differentiation	IDA IDA: Inferred from direct assay	15150273	GOA
involved in osteoblast differentiation	IDA IDA: Inferred from direct assay	15254224	GOA
involved in osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	27860183	GOA
acts upstream of positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18382765	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16049014	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	22540193	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	19664780	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	22540193	GOA
acts upstream of or within positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	18382765	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	16049014	GOA
involved in positive regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	17992660	GOA
acts upstream of or within positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9187146	GOA
involved in positive regulation of bone mineralization	IDA IDA: Inferred from direct assay	18436533	GOA
involved in positive regulation of bone mineralization involved in bone maturation	IDA IDA: Inferred from direct assay	16433617	GOA
acts upstream of or within positive regulation of cartilage development	IDA IDA: Inferred from direct assay	3201241	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	24778011	GOA
involved in positive regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	20890042	GOA
acts upstream of positive regulation of gene expression	IDA IDA: Inferred from direct assay	18382765	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	16243309	GOA
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	22450430	GOA
acts upstream of positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23399447	GOA
acts upstream of or within positive regulation of ossification	IDA IDA: Inferred from direct assay	9213002	GOA
involved in positive regulation of p38MAPK cascade	IDA IDA: Inferred from direct assay	22540193	GOA
acts upstream of or within positive regulation of peroxisome proliferator activated receptor signaling pathway	IGI IGI: Inferred from genetic interaction	28467929	GOA
acts upstream of or within positive regulation of phosphatase activity	IDA IDA: Inferred from direct assay	9213002	GOA
involved in positive regulation of protein binding	IDA IDA: Inferred from direct assay	16604073	GOA
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	17472960	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	8653785	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9187146	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16433617	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18326817	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15671031	GOA
acts upstream of or within telencephalon development	IDA IDA: Inferred from direct assay	9187146	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of BMP receptor complex	IDA IDA: Inferred from direct assay	16604073	GOA
located in cell surface	IDA IDA: Inferred from direct assay	22227436	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	22227436	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	16604073	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMP2 Protein Structure

TGFb_propeptide

TGF_beta

0
100
200
300
396 a.a.

Protein Preferred Names	Protein Names
bone morphogenetic protein 2	bone morphogenetic protein 2A

BMP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BMP2	P12643	BMPR1A	Homo sapiens	P36894	Competition Binding	19804412
Intra	BMP2	P12643	BMPR1A	Homo sapiens	P36894	SPR	21054789
Intra	BMP2	P12643	BMPR1A	Homo sapiens	P36894	X-Ray Diffraction	10881198
Intra	BMP2	P12643	BMPR1A	Homo sapiens	P36894	GMS	25938661
Intra	BMP2	P12643	BMPR1A	Homo sapiens	P36894	SPR	16672363
Intra	BMP2	P12643	BMPR1A	Homo sapiens	P36894	Anti Bait CoIP	19804412
Intra	BMP2	P12643	BMPR1A	Homo sapiens	P36894	Light Scattering	25938661
Intra	BMP2	P12643	BMPR1A	Homo sapiens	P36894	GMS	10881198
Intra	BMP2	P12643	BMPR1A	Homo sapiens	P36894	X-Ray Diffraction	15064755
Intra	BMP2	P12643	BMPR1A	Homo sapiens	P36894	Crosslink	19804412
Intra	BMP2	P12643	BMPR1A	Homo sapiens	P36894	SPR	20860622
Intra	BMP2	P12643	BMPR1A	Homo sapiens	P36894	GMS	16672363
Intra	BMP2	P12643	BMPR1A	Homo sapiens	P36894	SPR	25938661
Intra	BMP2	P12643	NOG	Homo sapiens	Q13253	SPR	19804412
Cross	BMP2	P12643	Acvr2a	Mus musculus	P27038	SPR	16672363
Intra	BMP2	P12643	HJV	Homo sapiens	Q6ZVN8	SPR	18335997
Intra	BMP2	P12643	RGMB	Homo sapiens	Q6NW40	Light Scattering	25938661
Intra	BMP2	P12643	RGMB	Homo sapiens	Q6NW40	X-Ray Diffraction	25938661
Intra	BMP2	P12643	RGMB	Homo sapiens	Q6NW40	GMS	25938661
Intra	BMP2	P12643	RGMB	Homo sapiens	Q6NW40	SAXS	25938661
Intra	BMP2	P12643	RGMB	Homo sapiens	Q6NW40	SPR	25938661
Intra	BMP2	P12643	HJV	Homo sapiens	Q6ZVN8-1	SPR	25938661
Intra	BMP2	P12643	HJV	Homo sapiens	Q6ZVN8-1	X-Ray Diffraction	25938661
Intra	BMP2	P12643	BMPR1B	Homo sapiens	O00238	SPR	19229295

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BMP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7006	BMP-2 Protein, Human/Mouse/Rat	P12643 (Q283-R396)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7006A	BMP-2 Protein, Human/Mouse/Rat (His)	P12643 (Q283-R396)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7006AF	Animal-Free BMP-2 Protein, Human/Mouse/Rat (His)	P12643 (Q283-R396)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700556	BMP-2 Protein, Human/Mouse/Rat (P. pastoris, His)	P12643 (Q283-R396)	≥ 90%, as determined by reducing SDS-PAGE.

BMP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81093	BMP-2 Antibody	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
HY-P84076	BMP-2 Antibody (YA3773)	ICC/IF, FC, ELISA	Human
HY-P84076A	BMP-2 Antibody (YA3773)(PBS only)	ICC/IF, FC, ELISA	Human
HY-P86447	BMP-2 Antibody (YA6139)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Short Stature, Facial Dysmorphism, And Skeletal Anomalies With Or Without Cardiac Anomalies 1	SSFSC1 Short Stature, Facial Dysmorphism, And Skeletal Anomalies With Or Without Cardiac Anomalies SSFSC
Brachydactyly, Type A2	Brachydactyly Type A2 BDA2 Mohr-Wriedt Type Brachydactyly Brachymesophalangy Ii Brachymesophalangy Type 2 Brachymesophalangy 2 Brachydactyly, Mohr-Wriedt Type Brachydactyly A2
Hemochromatosis, Type 1	Hemochromatosis Hemochromatosis Type 1 Hereditary Hemochromatosis Hh HFE1 Hfe Hemochromatosis, Modifier Of Symptomatic Form Of Classic Hemochromatosis Symptomatic Form Of Hemochromatosis Type 1 Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis Haemochromatosis Iron Storage Disorder Bronze Diabetes Hereditary Haemochromatosis Hlah Hfe Hemochromatosis, Hereditary Diabetes Bronze Classic Hemochromatosis Hfe-Associated Hereditary Hemochromatosis Hemochromatosis Classic Bronzed Cirrhosis Familial Hemochromatosis Genetic Hemochromatosis Hc Pigmentary Cirrhosis Primary Hemochromatosis Troisier-Hanot-Chauffard Syndrome Von Recklenhausen-Applebaum Disease Hemochromatosis 1 Primary Hereditary Hemochromatosis Bronze Cirrhosis
Atrial Septal Defect 1	ASD1 Atrial Heart Septal Defect 1 Asd
Short Stature, Facial Dysmorphism, And Skeletal Anomalies With Or Without Cardiac Anomalies 2	Short Stature, Facial Dysmorphism, And Skeletal Anomalies With Or Without Cardiac Anomalies SSFSC2 Ssfsc Doid:0112358
Transposition Of The Great Arteries, Dextro-Looped	Transposition Of The Great Arteries DTGA1 Dextro-Looped Transposition Of The Great Arteries DTGA Congenitally Uncorrected Transposition Of The Great Arteries Congenitally Uncorrected Transposition Of The Great Vessels D-Tga Isolated Ventriculoarterial Discordance Ventriculoarterial Discordance With Atrioventricular Concordance Dextro-Transposition Of The Great Arteries Transposition Of The Great Vessels Great Vessels Transposition Transposition Of The Great Arteries, Dextro-Looped 1 Arteries, Great, Transposition, Dextro-Looped Ventriculoarterial Discordance, Isolated D-Transposition Of The Great Arteries Complete Transposition Tga Tgv Transposition Of Great Vessels Transposition Of The Great Arteries Dextro-Looped 1 Dextro-Looped Transposition Of The Great Arteries 1 Discordant Ventriculoarterial Connection Complete Transposition Of Great Vessels Great Vessels Complete Transposition Total Great Vessel Transposition Transposition Of Great Arteries Complete Tga - [Transposition Of The Great Arteries] Tga - [Transposition Of Great Arteries] Tgv - [Transposition Of Great Vessels] Transposition Of Great Vessels Nos Transposed Vessels Nos
20p12.3 Microdeletion Syndrome	Del(20)(P12.3) Monosomy 20p12.3
Craniosynostosis 7	Craniosynostosis 7, Susceptibility To CRS7 Craniosynostosis 7, Digenic Crs7, Digenic Craniosynostosis, Susceptibility To, Type 7
Osteonecrosis	Bone Necrosis Avascular Necrosis Of Bone Aseptic Necrosis Necrosis Of Bone Nos Aseptic Osteonecrosis Aseptic Necrosis Of Bone, Site Unspecified Aseptic Or Avascular Bone Necrosis Aseptic Necrosis Of Bone Necrotic Bone Necrotizing Bone Spontaneous Osteonecrosis Osteoradionecrosis
Ankylosis
Brachydactyly
Osteomyelitis
Keutel Syndrome	KTLS Pulmonic Stenosis, Brachytelephalangism, And Calcification Of Cartilages Pulmonic Stenosis Brachytelephalangism And Calcification Of Cartilages Pulmonic Stenosis-Brachytelephalangism-Calcification Of Cartilages Syndrome
Degenerative Disc Disease	Intervertebral Disc Degeneration Cervical Disc Degenerative Disorder Cervical Disc Degenerative Disease Lumbar Disc Degeneration Vertebral Disc Disease Degeneration Of Lumbar Intervertebral Disc Intervertebral Disc Disorder Discogenic Disease
Osseous Heteroplasia, Progressive	Progressive Osseous Heteroplasia POH Osteoma Cutis Familial Ectopic Ossification Ectopic Ossification Familial Type Ectopic Ossification Heterotopic Ossification Ectopic Ossification, Familial Cutaneous Ossification Myositis Ossificans Progressiva Osteodermia Osteosis Cutis Ossification Heterotopic Heteroplasia, Osseous, Progressive Fibrodysplasia Ossificans Progressiva
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Dental Pulp Necrosis	Pulp Necrosis Necrotic Pulp Necrosis Of The Pulp Dead Pulp Devitalised Pulp Putrescent Pulpitis Devitalized Tooth Dental Pulp Gangrene Pulp Gangrene Nonvital Tooth Pulpless Tooth Putrescent Pulp
Embryonal Carcinoma	Embryonal Neoplasm Embryonal Cancer Primary Extragonadal Embryonal Carcinoma Embryo Neoplasm Carcinoma Embryonal Cancer Embryonal Carcinoma, Embryonal Extragonadal Embryonal Carcinoma Cancer, Embryonal
Fibrodysplasia Ossificans Progressiva	Myositis Ossificans Progressiva Progressive Myositis Ossificans FOP Progressive Ossifying Myositis Myositis Ossificans Stone Man Syndrome Man Of Stone Myositis Ossificans Progressive Diffuse Progressive Ossifying Polymyositis Fibrodysplasia Ossificans Congenita Myositis Ossificans Progressiva, Site Unspecified Münchmeyer Disease Fop - [Fibrodysplasia Ossificans Progressiva] Progressive Myositis Ossificans Calcification
Diastrophic Dysplasia	Diastrophic Dwarfism DTD Dd Diastrophic Dysplasia, Broad Bone-Platyspondylic Variant Dysplasia, Diastrophic Diastrophic Dysplasia Variant
Otosclerosis	Otospongiosis
Teratocarcinoma	Mixed Embryonal Carcinoma And Teratoma
Chondrosarcoma	Cartilaginous Cancer Chondrosarcoma Of Bone Primary Chondrosarcoma Of The Bone CHDSA
Endosteal Hyperostosis, Autosomal Dominant	Osteosclerosis Worth Syndrome Osteosclerosis, Autosomal Dominant Hyperostosis, Endosteal Endosteal Hyperostosis, Worth Type Worth Disease Autosomal Dominant Endosteal Hyperostosis Autosomal Dominant Osteosclerosis, Worth Type Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus Autosomal Dominant Osteosclerosis Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus Worth'S Syndrome Worth Type Autosomal Dominant Osteosclerosis Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus Osteosclerosis, Autosomal Dominant, Worth Type WENHY Endosteal Hyperostosis Autosomal Dominant Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus Osteosclerosis Autosomal Dominant Acquired Osteosclerosis
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Pilomatrixoma	Pilomatricoma PTR Epithelioma Calcificans Of Malherbe Benign Pilomatricoma Calcifying Epithelioma Of Malherbe Pilomatricoma, Somatic Benign Pilomatrixoma Malherbe Calcifying Epithelioma
Spondylolisthesis	Slipped Vertebrae Acquired Spondylolisthesis
Pleomorphic Adenoma	Mixed Tumor Of The Salivary Gland Adenoma Pleomorphic Adenoma, Pleomorphic Mixed Salivary Gland Tumor Mixed Tumor, Not Otherwise Specified
Osteoarthritis	Osteoarthrosis Degenerative Joint Disease Hypertrophic Arthritis Arthropathy Degenerative Polyarthritis Degenerative Arthritis Osteoarthrosis And Allied Disorder Arthritis, Degenerative Oa Osteoarthritis Deformans Osteoarthrosis Deformans Kashin-Beck Disease
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Ischemic Bone Disease
Ossification Of The Posterior Longitudinal Ligament Of Spine	OPLL Ossification Of The Posterior Longitudinal Ligament Of The Spine Ossification Of Posterior Longitudinal Ligament Of Spine Ossification, Posterior Longitudinal Ligament Spine
Dental Pulp Disease	Dental Pulp Diseases Dental Pulp Disorder Disorder Of Pulp Of Tooth Pulp Disorder
Wolff-Parkinson-White Syndrome	Wolff-Parkinson-White Pattern Wpw Syndrome Anomalous Atrioventricular Excitation Anomalous A-V Excitation Ventricular Pre-Excitation With Arrhythmia WPWS Ventricular Familial Preexcitation Syndrome Preexcitation Syndrome Ventricular Preexcitation Wpw - [Wolff-Parkinson- White] Syndrome Pre-Excitation Syndrome
Aortic Valve Disease 2	Aortic Valve Stenosis Aortic Stenosis Rheumatic Aortic Stenosis AOVD2 Bicuspid Aortic Valve Rheumatic Aortic Valve Stenosis Valvular Aortic Stenosis Aortic Valve Disease, Type 2 Aortic Valve Stricture Aortic Valve Obstruction Obstructed Aorta Valve Rheumatic Aortic Obstruction Rheumatic Aortic Valve Obstruction Rheumatic Aortic Stricture Aortic Valve Regurgitation Aortic Insufficiency With Stenosis Rheumatic Aortic Valve Stenosis With Insufficiency Rheumatic Aortic Stenosis With Incompetence Rheumatic Aortic Stenosis With Regurgitation
Gingival Recession	Localized Gingival Recession Gingival Recession, Localized Minimal Gingival Recession Moderate Gingival Recession Severe Gingival Recession Gingival Recession, Minimal Gingival Recession, Severe Atrophy Of Gums Gum Atrophy Gingival Atrophy
Spondylosis	Lumbar Spondylosis With Myelopathy Lumbosacral Spondylosis Without Myelopathy Spondylogenic Compression Of Lumbar Spinal Cord Spondylogenic Compression Of Thoracic Spinal Cord Spondylosis With Myelopathy Thoracic Or Lumbar Spondylosis With Myelopathy
Dental Caries	Dental Caries Extending Into Pulp Dental Caries Of Smooth Surface Dental Caries Pit And Fissure Smooth Surface Dental Caries Dental Decay Carious Teeth Dental Cavity Saprodontia Teeth Decayed Tooth Caries Tooth Decay
Spondylolysis	Acquired Spondylolysis
Craniopharyngioma	Neoplasm Of Rathke'S Pouch Adamantinomatous Tumor Craniopharyngeal Duct Tumor Dysodontogenic Epithelial Tumor Rathke'S Pouch Tumor
Hyperphosphatemia
Proximal Symphalangism	Cushing'S Symphalangism Symphalangism, Proximal Hereditary Absence Of Proximal Interphalangeal Joints Strasburger-Hawkins-Eldridge Syndrome Strasburger-Hawkins-Eldridge-Hargrave-Mckusick Syndrome Symphalangism, Proximal, 1a Symphalangism, Proximal, 1b Vessel'S Syndrome Symphalangism, Cushing Type
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Tooth Resorption
Diffuse Idiopathic Skeletal Hyperostosis	Hyperostosis, Diffuse Idiopathic Skeletal Ankylosing Vertebral Hyperostosis Dish Disseminated Idiopathic Skeletal Hyperostosis Forestier Disease Forestier'S Disease Hyperostosis Diffuse Idiopathic Skeletal
Bone Remodeling Disease
Bone Resorption Disease	Bone Resorption
Glucocorticoid-Induced Osteoporosis	Steroid-Induced Osteoporosis
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Bone Structure Disease
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Intervertebral Disc Disease	Lumbar Disc Disease Intervertebral Disc Disorder IDD Lumbar Disc Herniation Lumbar Disc Degeneration Intervertebral Disc Disease, Susceptibility To Lumbar Disc Herniation, Susceptibility To Lumbar Disc Disease, Susceptibility To Intervertebral Disc Degeneration Discogenic Disease Discogenic Disorder Disorder Of Intervertebral Disc Intervertebral Disk Degeneration Intervertebral Disk Disease Ldd Ldh Lumbar Disc Degeneration, Susceptibility To Degeneration Of Lumbar Intervertebral Disc Intervertebral Disk Displacement
Dental Pulp Calcification	Pulp Calcification Pulp Calcifications Pulpal Calcifications Dental Pulp Stone
Cardiomyopathy, Familial Restrictive, 3	RCM3 Restrictive Cardiomyopathy 3 Familial Restrictive Cardiomyopathy 3 Cardiomyopathy, Familial Restrictive 3 Cardiomyopathy, Restrictive, Familial, Type 3
Adult Liposarcoma
Bone Deterioration Disease
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Plantar Fasciitis	Fasciitis, Plantar
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Radiculopathy	Pinched Nerve Nerve Root Disorder Radiculopathy, Site Unspecified Radicular Neuropathy Radicular Syndrome Radicular Pain Radiculitis Radiculitis Nos Spinal Root Pain Nerve Root Neuritis Radiculopathy In Spondylosis
Osteochondritis Dissecans	Osteochondritis Ocd Konig Disease
Chronic Recurrent Multifocal Osteomyelitis	Chronic Multifocal Osteomyelitis CRMO Cmo Cno/Crmo Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis Osteomyelitis, Chronic Multifocal Multifocal Osteomyelitis, Chronic Chronic Osteomyelitis Chronic Multifocal Osteomyelitis, Unspecified Site Crmo - [Chronic Multifocal Osteomyelitis] Chronic Osteomyelitis With Draining Sinus, Unspecified Site Bone Fistula With Chronic Osteomyelitis
Arthropathy	Ankylosis Of Ankle And Foot Joint Ankylosis Of Forearm Joint Ankylosis Of Hand Joint Ankylosis Of Joint Of Ankle And/Or Foot Ankylosis Of Joint Of Forearm Ankylosis Of Joint Of Hand Ankylosis Of Joint Of Lower Leg Ankylosis Of Joint Of Multiple Sites Ankylosis Of Joint Of Pelvic Region And Thigh Ankylosis Of Joint Of Shoulder Region Ankylosis Of Joint Of Upper Arm Ankylosis Of Lower Leg Joint Ankylosis Of Multiple Joints Ankylosis Of Upper Arm Joint Infectious Arthropathy Joint Ankylosis Of The Ankle And Foot Joint Ankylosis Of The Ankle And/Or Foot Joint Ankylosis Of The Forearm Joint Ankylosis Of The Hand Joint Ankylosis Of The Lower Leg Joint Ankylosis Of The Pelvic Region And Thigh Joint Ankylosis Of The Shoulder Region Joint Ankylosis Of The Upper Arm Joint Diseases Joint Disease Arthropathy Associated With Infection
Hemochromatosis Type 2	Juvenile Hemochromatosis Juvenile Hereditary Hemochromatosis Hfe2 Jhh Hemochromatosis Juvenile Iron Overload Disease Juvenile Hemochromatosis, Juvenile Hemochromatosis, Type 2 Hemochromatosis Hemochromatosis, Type 1
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Fibrochondrogenesis	Fbcg1 Fbcg2 Fibrochondrogenesis-1 Fibrochondrogenesis-2 Fibrochondrogenesis 1 Fibrochondrogenesis 2
Exostosis	Osteophyte Exostoses Orbital Exostosis Exostosis Of Orbit Bone Spur Bony Outgrowth Swimmer'S Exostosis Osteophytes External Exotoses Cartilaginous Exostosis
Cartilage Disease	Cartilage Diseases Cartilage Cartilage Disorder Chondropathy Cartilage Disorders
Enchondromatosis, Multiple, Ollier Type	Ollier Disease Enchondromatosis Dyschondroplasia Osteochondromatosis Multiple Cartilaginous Enchondroses Multiple Enchondromatosis Enchondromatosis With Haemangiomata Enchondromatosis, Multiple Kast'S Syndrome Ollier'S Syndrome Enchondromatosis Multiple ENCHOM Maffucci Disease Olliers Disease Hereditary Multiple Exostoses Chondromatosis
Osteochondrosis	Osteochondritis Apophysitis Epiphysitis Osteochondritis Juvenilis Epiphyseal Necrosis Juvenile Osteochondrosis Of Tibial Tubercle
Dyssegmental Dysplasia, Silverman-Handmaker Type	DDSH Silverman-Handmaker Type Dyssegmental Dysplasia Dyssegmental Dysplasia Silverman-Handmaker Type Dyssegmental Dwarfism Silverman-Handmaker Type Dyssegmental Dwarfism, Silverman-Handmaker Type Anisospondylic Camptomicromelic Dwarfism, Silverman-Handmaker Type Anisospondylic Camptomicromelic Dwarfism Silverman-Handmaker Type Dysplasia, Dyssegmental, Silverman-Handmaker Type
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted
Bone Development Disease
Cleidocranial Dysplasia	Cleidocranial Dysostosis CLCD Cleidocranial Dysplasia, Forme Fruste, Dental Anomalies Only Cleidocranial Dysplasia, Forme Fruste, With Brachydactyly CCD Marie-Sainton Disease Dysplasia Cleidocranial Dento-Osseous Dysplasia Marie-Sainton Syndrome Dysplasia, Cleidocranial
Juvenile Polyposis Syndrome	JPS Juvenile Intestinal Polyposis Jip Pji Juvenile Gastrointestinal Polyposis Juvenile Polyposis Polyposis, Juvenile Intestinal Polyposis, Familial, Of Entire Gastrointestinal Tract Polyposis Familial Of Entire Gastrointestinal Tract Polyposis Juvenile Intestinal Polyposis Syndrome, Juvenile
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Diabetes Mellitus	Diabetes
Diamond-Blackfan Anemia 6	DBA6 Aase-Smith Syndrome Ii Aase Syndrome Aase Smith Syndrome 2 Rpl5-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 6 Diamond-Blackfan Anemia 1
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Brachydactyly, Type A1	Brachydactyly Type A1 BDA1 Farabee-Type Brachydactyly Farabee Type Brachydactyly Brachydactyly Farabee Type Brachydactyly, Farabee Type Brachydactyly A1 Brachydactyly
Synostosis
Stickler Syndrome, Type I	Stickler Syndrome 1 Stickler Syndrome Type 1 STL1 Aom Stickler Syndrome, Type 1 Stickler Syndrome, Vitreous Type 1 Stickler Syndrome, Membranous Vitreous Type Arthroophthalmopathy, Hereditary Progressive Arthro-Ophthalmopathy Hereditary Progressive Stickler Syndrome Membranous Vitreous Type Stickler Syndrome Type I Stickler Syndrome Vitreous Type 1
Orofacial Cleft	Cleft, Orofacial
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100009	Ufenamate	Inhibitor	99.89%	Unkown

Pre-clinical Phase

Bioactive Molecules (40)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126675A	AS2863619		98.02%	Unkown
HY-16712	LDN-214117	Inhibitor	99.54%	Unkown
HY-P0254	Kisspeptin-10, human		99.86%	Unkown
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-N0265	Asperosaponin VI	Inhibitor	99.62%	Unkown
HY-N0316	Mollugin		99.79%	Unkown
HY-N2375	L-Quebrachitol	Activator	99.51%	Unkown
HY-P5832	BMP2-derived peptide	Activator	98.04%	Unkown
HY-126675	AS2863619 free base		99.87%	Unkown
HY-123940	SGC-AAK1-1	Inhibitor	98.47%	Unkown
HY-107245	Segetalin B		99.9%	Unkown
HY-P0254A	Kisspeptin-10, human TFA		99.56%	Unkown
HY-101290A	BMT-090605 hydrochloride	Inhibitor	98.76%	Unkown
HY-120179	LP-922761		98.21%	Unkown
HY-142042	3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles	Inhibitor	99.84%	Unkown
HY-Y1123	2-Aminoacetamide hydrochloride	Activator	99.89%	Unkown
HY-158203	BMP agonist 2	Agonist	99.26%	Unkown
HY-N8920	Syringetin		99.42%	Unkown
HY-135871	BMT-124110		99.15%	Unkown
HY-162653	SGC-CDKL2/AAK1/BMP2K-1		98.55%	Unkown
HY-173149	CDD-2789	Inhibitor	/	Unkown
HY-N0946	(-)-Pinoresinol 4-O-glucoside	Inhibitor	98.0%	Unkown
HY-120179A	LP-922761 hydrate		98.0%	Unkown
HY-135871A	BMT-124110 formic	Inhibitor	/	Unkown
HY-N8261	Amicoumacin B		98.8%	Unkown
HY-RS01536	BMP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01537	BMP2K Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181293	PROTAC AAK1 degrader-1	Degrader	/	Unkown
HY-N0265R	Asperosaponin VI (Standard)	Inhibitor	99.46%	Unkown
HY-RS17130	Bmp2k Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W190842	m-PEG2-NHS ester		98.0%	Unkown
HY-101290	BMT-090605	Inhibitor	98.27%	Unkown
HY-121025	BUR1	Inhibitor	99.65%	Unkown
HY-126675G	AS2863619 (GMP)		/	Unkown
HY-N16118	Asperosaponin V	Modulator	/	Unkown
HY-N2682B	Dehydrodiconiferyl alcohol	Agonist	98.32%	Unkown
HY-RS01553	Bmpr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16626	Bmp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23061	Bmp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23575	Bmp2k Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BMP2	VGNC	VGNC:80033
Mus musculus	BMP2	MGD	MGI:88177
Rattus norvegicus	BMP2	RGD	RGD:2211
Macaca mulatta	BMP2	VGNC	VGNC:70261
Canis familiaris	BMP2	VGNC	VGNC:38478
Bos taurus	BMP2	VGNC	VGNC:26517
Others	BMP2	NCBI