Abca1 - ATP binding cassette subfamily A member 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 313210

Summary

Enables ATPase-coupled transmembrane transporter activity and high-density lipoprotein particle binding activity. Involved in several processes, including cellular response to cholesterol; lipid transport; and lipoprotein biosynthetic process. Located in basolateral plasma membrane and cell surface. Biomarker of several diseases, including extrahepatic cholestasis; fatty liver disease; membranous glomerulonephritis; obesity; and premature menopause. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hypolipoproteinemia (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human ABCA1 (ATP binding cassette subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Abca1 Products (1)

mRNA Protein Name
NM_178095.3 NP_835196.2 phospholipid-transporting ATPase ABCA1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATPase-coupled transmembrane transporter activity IDA
IDA: Inferred from direct assay
12909583 RGD
enables high-density lipoprotein particle binding IDA
IDA: Inferred from direct assay
15907796 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to cholesterol IEP
IEP: Inferred from expression pattern
15907796 RGD
involved in cellular response to cytokine stimulus IEP
IEP: Inferred from expression pattern
25445438 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
21554872 RGD
involved in cholesterol transport IDA
IDA: Inferred from direct assay
12909583 RGD
involved in cholesterol transport IMP
IMP: Inferred from mutant phenotype
14993246 RGD
involved in lipoprotein biosynthetic process IEP
IEP: Inferred from expression pattern
21554872 RGD
involved in lipoprotein biosynthetic process IMP
IMP: Inferred from mutant phenotype
14993246 RGD
involved in phospholipid transport IDA
IDA: Inferred from direct assay
12909583 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
15710224 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
25612518 RGD
involved in response to vitamin B3 IEP
IEP: Inferred from expression pattern
19878707 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
14690017 RGD
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
28660384 RGD
located in cell surface IDA
IDA: Inferred from direct assay
15907796 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phospholipid-transporting ATPase ABCA1

  • ATP-binding cassette sub-family A member 1

  • ATP-binding cassette, sub-family A (ABC1), member 1

  • ATP-binding cassette, subfamily A (ABC1), member 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0388 Probucol 99.92% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-134377 Bocidelpar Modulator 98.08% Phase 2
HY-P6306A CS-6253 TFA 98.08% Phase 1

Pre-clinical Phase

Bioactive Molecules (34)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0086 DIDS sodium salt Inhibitor 99.13% Unkown
HY-W020012 Fluoresterol 99.65% Unkown
HY-P6306 CS-6253 98.84% Unkown
HY-N2419 Erythrodiol 99.75% Unkown
HY-18282 AZ876 Agonist 99.77% Unkown
HY-123402 GSK3987 Agonist 99.19% Unkown
HY-N0686 Pseudoprotodioscin Inhibitor 99.17% Unkown
HY-143200 OSBPL7-IN-1 Inhibitor 99.84% Unkown
HY-123148 IMB-808 Agonist 99.84% Unkown
HY-N0364 Falcarindiol 99.48% Unkown
HY-141645 IMM-H007 97.69% Unkown
HY-117006 E1231 Activator 98.46% Unkown
HY-NP203 High density lipoprotein (human) Activator 98.00% Unkown
HY-W674245 10-Hydroxyhexadecanoic acid 99.53% Unkown
HY-W590664 C2 Dihydroceramide 99.9% Unkown
HY-122936 Tanshindiol C 98.47% Unkown
HY-173230 ABCA1 inducer 2 98.22% Unkown
HY-RS00037 ABCA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W201317 E17241 Agonist 95.04% Unkown
HY-185104 Ginsenoside C-K hexapropionate ester Agonist 98.88% Unkown
HY-115780 E17110 Agonist / Unkown
HY-117555 4010B-30 Activator / Unkown
HY-121671 TBTC Activator 97.22% Unkown
HY-121693 DIDS Inhibitor / Unkown
HY-169080 ABCA1 inducer 1 Inducer / Unkown
HY-170570 PFM046 / Unkown
HY-179278 LXR agonist 4 Agonist / Unkown
HY-184312 PPAR agonist 8 / Unkown
HY-184354 NO-Pravastatin / Unkown
HY-186045 SKLB06489 / Unkown
HY-N13361 Elodeoidileon A Agonist / Unkown
HY-181520 ABCA1 inducer 3 Inducer / Unkown
HY-RS16554 Abca1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22987 Abca1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abca1 NCBI NCBI:19