MLN - motilin Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4295

About MLN

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:33,794,673-33,804,003 (from NCBI)

This gene has 3 transcripts (splice variants) and 92 orthologues. Restricted expression toward duodenum (RPKM 82.5).

Summary

This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. [provided by RefSeq, May 2010]

MLN Products (3)

mRNA	Protein	Name
NM_001040109.2	NP_001035198.1	promotilin isoform 2 preproprotein
NM_001184698.2	NP_001171627.1	promotilin isoform 3 preproprotein
NM_002418.3	NP_002409.1	promotilin isoform 1 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables motilin receptor binding	IPI IPI: Inferred from physical interaction	10381885	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLN Protein Structure

Motilin_ghrelin

Motilin_assoc

0
100
115 a.a.

Protein Preferred Names	Protein Names
promotilin	prepromotilin

MLN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MLN	P12872	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	MLN	P12872	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	MLN	P12872	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	MLN	P12872	TTC19	Homo sapiens	Q6DKK2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MLN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70285	Promotilin/MLN Protein, Human (HEK293, His)	P12872-1 (F26-K115)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Gastroparesis	Gastroparesis Syndrome Delayed Gastric Emptying Gastric Atonia Gastroparalysis
Duodenogastric Reflux
Functional Gastric Disease
Pylorospasm
Dumping Syndrome	Jejunal Syndrome Dumping Dumping Syndrome Postgastrectomy Syndromes Postgastric Surgery Syndrome Postgastrectomy Syndrome Post Cibal Syndrome Postgastrectomy Dumping Syndrome
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Neurogenic Bowel
Pyloric Stenosis
Autonomic Neuropathy	Diabetic Autonomic Neuropathy
Constipation
Zollinger-Ellison Syndrome	Gastrinoma Pancreatic Ulcerogenic Tumor Syndrome Z E Syndrome Zes Ze - [Zollinger-Ellison] Syndrome
Hypertrophic Pyloric Stenosis	Congenital Hypertrophic Pyloric Stenosis Pyloric Stenosis, Hypertrophic Congenital Or Infantile Stricture Of Pylorus Achalasia Of The Pylorus Congenital Hypertrophy Of The Pylorus Infantile Hypertrophy Of The Pylorus Infantile Constriction Of The Pylorus Congenital Stenosis Of The Pylorus Congenital Constriction Of The Pylorus Congenital Stricture Of The Pylorus Infantile Hypertrophic Pyloric Stenosis Infantile Stenosis Of The Pylorus Infantile Stricture Of The Pylorus Congenital Or Infantile Constriction Of Pylorus Infantile Pyloric Obstruction Infantile Pyloric Hypertrophy Pylorus Achalasia Pyloric Constriction Infantile Pyloric Stricture Infantile Pyloric Stenosis Congenital Spasm Of Pylorus Congenital Pylorospasm Congenital Pyloric Stricture Congenital Pyloric Spasm Congenital Or Infantile Spasm Of Pylorus Congenital Or Infantile Obstruction Of Pylorus Congenital Pyloric Stenosis
Functional Colonic Disease	Colonic Diseases, Functional
Irritable Bowel Syndrome	Irritable Colon Psychogenic Ibs Ibs - [Irritable Bowel Syndrome] Spastic Bowel Syndrome
Gallbladder Disease	Gallbladder Diseases Gall Bladder Gall Bladder Diseases Abnormal Gallbladder Function
Space Motion Sickness
Acute Porphyria	Porphyrias, Hepatic Hepatic Porphyria Porphyria Hepatic Acute Intermittent Porphyria
Duodenal Ulcer	Stress Ulcer Curling Ulcer Stress Ulcer Of Stomach Curling'S Ulcers Duodenal Ulcer Disease Duodenal Ulcers Duodenal Peptic Ulcer
Postgastrectomy Syndrome	Postgastrectomy Syndromes Postgastric Surgery Syndrome
Rumination Disorder	Rumination Syndrome Psychogenic Rumination Rumination Disorders
Paralytic Ileus	Adynamic Ileus Paralytic Ileus Of Bowel Ileus Nos Paralysis Of Bowel Paralysis Of Intestine Adynamic Intestinal Obstruction Paralytic Intestinal Ileus
Colonic Pseudo-Obstruction	Primary Chronic Pseudo-Obstruction Of Colon
Functional Diarrhea	Functional Diarrhoea
Gastrointestinal System Disease	Gastrointestinal Disease Gastrointestinal Diseases Alimentary System Disease Digestive System Disorder Gastroenteropathy Gastrointestinal Disorder Git Disease Digestive System Diseases Gastrointestinal Disorders Digestive System Disease Digestive System Disorders
Pneumatosis Cystoides Intestinalis
Postcholecystectomy Syndrome	Post Cholecystectomy Syndrome
Gastroenteritis	Cholera Morbus Infectious Colitis, Enteritis And Gastroenteritis Enteritis Due To Astrovirus Rotaviral Gastroenteritis Viral Gastroenteritis Due To Rotavirus
Esophagitis	Acute Esophagitis
Perianal Hematoma	External Thrombosed Haemorrhoids Thrombosed External Hemorrhoids
Dyskinesia Of Esophagus	Esophageal Motility Disorders Dyskinesia Of Oesophagus Esophageal Dysmotility Esophageal Motility Disorder Oesophageal Dysmotility Oesophageal Motor Disorder Esophageal Spasm
Blind Loop Syndrome	Bacterial Overgrowth Syndrome
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Volvulus Of Midgut	Volvulus Intestinal Volvulus Intestinal Malrotation, Familial Familial Intestinal Malrotation Twist Of Intestine, Bowel, Or Colon
Peptic Esophagitis	Reflux Esophagitis Peptic Reflux Disease Reflux Oesophagitis Esophagitis, Peptic Gastro-Esophageal Reflux Disease With Esophagitis
Hernia, Hiatus	Hiatal Hernia Hiatus Hernia Diaphragmatic - Hiatus -Hernia Hernia, Hiatal
Intestinal Obstruction	Inspissated Milk Syndrome Milk Curd Syndrome
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Intestinal Pseudo-Obstruction	Chronic Intestinal Pseudoobstruction Chronic Intestinal Pseudo-Obstruction Cipo Neuronal Intestinal Dysplasia Hollow Visceral Myopathy Familial Visceral Neuropathy Paralytic Ileus Intestinal Pseudoobstruction Chronic Idiopathic Intestinal Pseudo-Obstruction Ciip Congenital Short Bowel Syndrome Enteric Neuropathy Familial Visceral Myopathy Ipo Pseudo-Obstruction Of Intestine Pseudointestinal Obstruction Syndrome Pseudoobstructive Syndrome Congenital Idiopathic Intestinal Pseudoobstruction Visceral Myopathy, Familial
Capillary Malformations, Congenital	Familial Multiple Nevi Flammei Nevi Flammei, Familial Multiple CMC Port-Wine Stain Capillary Malformations Cmal Familial Multiple Port-Wine Stains Capillary Malformation Capillary Malformations, Congenital, 1, Somatic, Mosaic Congenital Capillary Malformations Port-Wine Stain Familial Multiple Hereditary Capillary Malformations Capillary Malformations, Hereditary Capillary Malformations, Congenital, Type 1, Somatic, Mosaic Strawberry Nevus Of Skin Naevus Flammeus
Diabetes Mellitus	Diabetes
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10453	Ixazomib		99.85%	Yes
HY-15246	Tovorafenib	Inhibitor	99.17%	Unkown
HY-10452	Ixazomib citrate		99.87%	Yes

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9911	Vedolizumab	Antagonist	99.90%	Unkown

Clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10971	Alisertib		99.84%	Phase 3
HY-10484	Pevonedistat hydrochloride		99.19%	Phase 3
HY-13328	Sapanisertib		99.88%	Phase 2
HY-19414	MLN-4760	Inhibitor	99.93%	Phase 2
HY-12285	Serabelisib	Inhibitor	99.44%	Phase 2
HY-10202	Tandutinib		99.48%	Phase 2
HY-100487	TAK-243		99.86%	Phase 1
HY-128586	TAS4464		99.21%	Phase 1
HY-10180	MLN8054	Inhibitor	99.01%	Phase 1
HY-123763	MLN3126	Antagonist	98.02%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99781	Plozalizumab	Inhibitor	99.53%	Phase 2
HY-P99662	Indusatumab vedotin		96.37%	Phase 2

Pre-clinical Phase

Bioactive Molecules (24)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-70062	Pevonedistat		99.98%	Unkown
HY-111373	RapaLink-1		99.65%	Unkown
HY-15473	MLN120B	Inhibitor	99.76%	Unkown
HY-15155	MLN0905	Inhibitor	99.94%	Unkown
HY-N6746	Citrinin		99.94%	Unkown
HY-128586A	TAS4464 hydrochloride		98.91%	Unkown
HY-10202A	Tandutinib hydrochloride		99.29%	Unkown
HY-19414A	(R)-MLN-4760	Inhibitor	99.51%	Unkown
HY-15473A	MLN120B dihydrochloride	Inhibitor	99.45%	Unkown
HY-108090	MLN-0415	Inhibitor	98.02%	Unkown
HY-169358	L134	Degrader	99.37%	Unkown
HY-70062R	Pevonedistat (Standard)		99.51%	Unkown
HY-10971A	Alisertib sodium		/	Unkown
HY-10453S	Ixazomib-d7	Inhibitor	/	Unkown
HY-10180A	MLN8054 sodium	Inhibitor	/	Unkown
HY-123143	XR11576	Inhibitor	/	Unkown
HY-D3127	DCA-Mln		/	Unkown
HY-P6008	Myoregulin		/	Unkown
HY-P6008A	Myoregulin TFA		/	Unkown
HY-RS08498	MLN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08654	MRLN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-10202B	Tandutinib sulfate		/	Unkown
HY-RS23083	Mln Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W748328	Ixazomib-13C2,15N		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991360	MLN 591	Inhibitor	/	Unkown
HY-P991604	MLN2201	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MLN	VGNC	VGNC:74884
Rattus norvegicus	MLN	RGD	RGD:1642907
Felis catus	MLN	VGNC	VGNC:97180
Canis familiaris	MLN	VGNC	VGNC:54970
Bos taurus	MLN	VGNC	VGNC:31505
Others	MLN	NCBI