2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. L134

L134 is a potent PROTAC BRD4 degrader with a DC50 value of 7.36 nM. L134 mediates the degradation of BRD4 via the ubiquitin-proteasome system in a DCAF11-dependent manner (Blue: JQ-1 (carboxylic acid) (HY-78695), Black: linker (HY-W004640); Pink: E3 ligase ligand, L321 (HY-169359)).

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L134

L134 Chemical Structure

CAS No. : 3120166-93-7

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Based on 1 publication(s) in Google Scholar

L134 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

L134 is a potent PROTAC BRD4 degrader with a DC50 value of 7.36 nM. L134 mediates the degradation of BRD4 via the ubiquitin-proteasome system in a DCAF11-dependent manner (Blue: JQ-1 (carboxylic acid) (HY-78695), Black: linker (HY-W004640); Pink: E3 ligase ligand, L321 (HY-169359))[1].

IC50 & Target[1]

Cereblon

 

BRD4

7.36 nM (DC50)

Molecular Weight

962.47

Formula

C48H51ClF3N7O7S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=CC=C(C(/C=C2C(NC3=C\2C=CC(C(F)(F)F)=C3)=O)=C1)OCC(NCCCOCCOCCOCCCNC(C[C@@H]4N=C(C5=C(N6C4=NN=C6C)SC(C)=C5C)C7=CC=C(C=C7)Cl)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (51.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0390 mL 5.1950 mL 10.3899 mL
5 mM 0.2078 mL 1.0390 mL 2.0780 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0390 mL 5.1950 mL 10.3899 mL 25.9748 mL
5 mM 0.2078 mL 1.0390 mL 2.0780 mL 5.1950 mL
10 mM 0.1039 mL 0.5195 mL 1.0390 mL 2.5975 mL
15 mM 0.0693 mL 0.3463 mL 0.6927 mL 1.7317 mL
20 mM 0.0519 mL 0.2597 mL 0.5195 mL 1.2987 mL
25 mM 0.0416 mL 0.2078 mL 0.4156 mL 1.0390 mL
30 mM 0.0346 mL 0.1732 mL 0.3463 mL 0.8658 mL
40 mM 0.0260 mL 0.1299 mL 0.2597 mL 0.6494 mL
50 mM 0.0208 mL 0.1039 mL 0.2078 mL 0.5195 mL
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L134 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L1343120166-93-7L 134L-134PROTACsEpigenetic Reader DomainPROTAC BRD4 Degraderubiquitin-proteasome systemDCAF11Inhibitorinhibitorinhibit

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