2. Gene
  3. IGF1R - insulin like growth factor 1 receptor Gene

IGF1R - insulin like growth factor 1 receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Canis lupus familiaris (sub-species: familiaris)
Gene ID: 442951 | Gene type: protein coding

About IGF1R

Primary_assembly 3: 42,203,091-42,501,470 forward strand.ROS_Cfam_1.0:CM025102.1

This gene has 3 transcripts (splice variants), 276 orthologues and 54 paralogues.

IGF1R Products(2)

mRNA Protein Name
XM_038661228.1 XP_038517156.1 insulin-like growth factor 1 receptor isoform X2
XM_038661229.1 XP_038517157.1 insulin-like growth factor 1 receptor isoform X1

IGF1R Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (50 - 160)

Furin-like

Furin-like: pfam00757 (174 - 329)

Recep_L_domain

Recep_L_domain: pfam01030 (351 - 466)

FN3

FN3: cd00063 (493 - 605)

FN3

FN3: cd00063 (610 - 653)

FN3

FN3: cd00063 (834 - 923)

PTKc_InsR_like

PTKc_InsR_like: cd05032 (991 - 1267)

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  • 1367 a.a.
Protein Preferred Names Protein Names

insulin-like growth factor 1 receptor

receptor tyrosine kinase

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15656 Ceritinib Inhibitor 99.95% Yes
HY-15656A Ceritinib dihydrochloride Inhibitor 99.90% Yes
HY-B0025 Voglibose Inhibitor 98.0% Unkown
HY-15656AR Ceritinib dihydrochloride (Standard) Inhibitor / Unkown
HY-15656R Ceritinib (Standard) Inhibitor 99.72% Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99165 Teprotumumab Inhibitor 99.46% Unkown
Clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-15494 Picropodophyllin 99.85% Phase 2
HY-10200 BMS-754807 Inhibitor 99.42% Phase 2
HY-19565 KW-2450 tosylate / Phase 2
HY-B0794B AZ7550 Mesylate Inhibitor 98.70% Phase 1
HY-B0794 AZ7550 Inhibitor 97.09% Phase 1
HY-15749 XL228 Inhibitor 99.64% Phase 1
HY-13326 ASP3026 99.88% Phase 1
HY-B0794A AZ7550 hydrochloride Inhibitor 98.66% Phase 1
Inhibitory Antibodies (8)
Cat. No. Product Name Effect
Purity Phase
HY-P99294 Ganitumab Inhibitor 96.00% Phase 3
HY-P990084 Veligrotug 99.25% Phase 3
HY-P99189 Cixutumumab Inhibitor 99.63% Phase 2
HY-P99284 Dalotuzumab 97.43% Phase 2
HY-P99197 Figitumumab Inhibitor ≥99.0% Phase 2
HY-P99218 Robatumumab Inhibitor 98.00% Phase 2
HY-P99712 Lonigutamab 95.00% Phase 2
HY-P99672 Istiratumab Inhibitor 98.45% Phase 2
Pre-clinical Phase
Bioactive Molecules (65)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113402 Gamma-glutamylcysteine 98.53% Unkown
HY-116624 MAZ51 99.96% Unkown
HY-50866 NVP-AEW541 99.92% Unkown
HY-10262 BMS-536924 99.83% Unkown
HY-15609 AZD-3463 99.31% Unkown
HY-10252 NVP-ADW742 99.30% Unkown
HY-10253 AG1024 99.50% Unkown
HY-13203 NVP-TAE 226 99.77% Unkown
HY-N7922 Urolithin M5 Inhibitor 97.31% Unkown
HY-N0908 Ginsenoside Rg5 99.88% Unkown
HY-10524 GSK1904529A 99.03% Unkown
HY-N1990 Gypenoside XLIX 99.88% Unkown
HY-113402A Gamma-glutamylcysteine TFA 96.68% Unkown
HY-P5133 Synstatin (92-119) Inhibitor 97.61% Unkown
HY-Y1322 Triphenyl phosphate 99.67% Unkown
HY-P3226 JB-1 99.63% Unkown
HY-100349 SU4312 Inhibitor 99.74% Unkown
HY-P5438 Srctide Substrate 99.71% Unkown
HY-18785 Indirubin Derivative E804 Inhibitor 98.54% Unkown
HY-113402R Gamma-glutamylcysteine (Standard) 98.14% Unkown
HY-135680 I-OMe-Tyrphostin AG 538 Inhibitor 98.03% Unkown
HY-145110 IGF-1R inhibitor-2 Inhibitor 98.36% Unkown
HY-156914 IGF-1R/SRC-IN-1 Inhibitor 99.86% Unkown
HY-125102 AZ12253801 Inhibitor / Unkown
HY-15656S Ceritinib-d7 Inhibitor 98.00% Unkown
HY-177760 PrCP-7414 / Unkown
HY-15494R Picropodophyllin (Standard) 99.70% Unkown
HY-21291 SU-4313 Modulator 99.31% Unkown
HY-B0794S AZ7550-d5 Inhibitor / Unkown
HY-N6611 Chimaphilin Inhibitor 99.80% Unkown
HY-50866B NVP-AEW541 dihydrochloride / Unkown
HY-100038 AZD9362 Inhibitor / Unkown
HY-10252A cis-NVP-ADW742 Inhibitor / Unkown
HY-10438 BMS-577098 Inhibitor / Unkown
HY-108230 ALK-IN-12 Inhibitor / Unkown
HY-116059 EGFR-IN-199 Inhibitor / Unkown
HY-118046 GSK2163632A Inhibitor / Unkown
HY-13312A GTx-134 / Unkown
HY-15494S Picropodophyllin-d3 / Unkown
HY-15494S1 Picropodophyllin-d6 / Unkown
HY-15656B Ceritinib mesylate Inhibitor / Unkown
HY-162506 IGF-1R inhibitor-3 Inhibitor / Unkown
HY-167854 KW-2450 free base Inhibitor / Unkown
HY-169572 IGF-1R inhibitor-5 Inhibitor / Unkown
HY-169600 IGF-1R inhibitor-4 Inhibitor / Unkown
HY-17603A (E)-Belizatinib Inhibitor / Unkown
HY-177622 Cibrigirsen Inhibitor / Unkown
HY-177622A Cibrigirsen sodium Inhibitor / Unkown
HY-179732 PROTAC ALK degrader-4 / Unkown
HY-180972 PROTAC EML4-ALK Degrader-2 Inhibitor / Unkown
HY-182264 Masoprocol tetrapivalate Inhibitor / Unkown
HY-183292 SH-1092 Inhibitor / Unkown
HY-402309 IGF-1R modulator 1 Modulator / Unkown
HY-E70730 INSR Recombinant Human Active Protein Kinase / Unkown
HY-RS06615 IGF1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06616 Igf1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06617 Igf1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100349A cis-SU4312 Inhibitor / Unkown
HY-113402AR Gamma-glutamylcysteine TFA (Standard) / Unkown
HY-113402B Gamma-glutamylcysteine ammonium / Unkown
HY-14357 BMS 695735 Inhibitor / Unkown
HY-168616 CL-A3-7 Inhibitor / Unkown
HY-174654 Human IGF1R mRNA / Unkown
HY-174721 Human EGFR mRNA / Unkown
HY-W749516 Voglibose-13C3 Inhibitor / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P991134 Elegrobart Inhibitor 95.27% Unkown
HY-P991253 BIIB022 Inhibitor / Unkown
HY-P991255 VRDN-002 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens IGF1R NCBI NCBI:3480
Macaca fascicularis IGF1R NCBI NCBI:102130142
Mus musculus IGF1R NCBI NCBI:16001
Rattus norvegicus IGF1R NCBI NCBI:25718