IL21R - interleukin 21 receptor Gene

Also Known as NILR; CD360; IMD56

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 50615

About IL21R

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:27,402,174-27,452,042 (from NCBI)

This gene has 6 transcripts (splice variants), 131 orthologues, 7 paralogues and is associated with 70 phenotypes. Biased expression in lymph node (RPKM 10.1), appendix (RPKM 5.4) and 7 other tissues.

Summary

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I Cytokine Receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

IL21R Products (3)

mRNA	Protein	Name
NM_021798.4	NP_068570.1	interleukin-21 receptor isoform 1 precursor
NM_181078.3	NP_851564.1	interleukin-21 receptor isoform 1 precursor
NM_181079.5	NP_851565.4	interleukin-21 receptor isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables cytokine receptor activity	IDA IDA: Inferred from direct assay	11016959	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	11016959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
interleukin-21 receptor	IL-21 receptor

Recombinant IL21R Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72559	IL-21R Protein, Human (HEK293, His)	Q9HBE5 (C20-P236)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77714	IL-21R Protein, Human (HEK293, Fc)	Q9HBE5 (C20-P236)	≥ 95%, as determined by Bis-Tris PAGE.

IL21R Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84805	CD360 Antibody (YA4502)	ICC/IF, FC, ELISA	Human
HY-P84805A	CD360 Antibody (YA4502)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Immunodeficiency 56	Il21r Immunodeficiency IMD56 Combined Immunodeficiency Due To Il21r Deficiency Autosomal Recessive Primary Immunodeficiency Il21r-Related
Ige Responsiveness, Atopic	ATOPY Atopy, Susceptibility To Ige, Elevated Level Of IGER Immunoglobulin E, Basic Level Of, In Serum Ige, Level Of Igel Ige Response Underlying Allergic Asthma And Rhinitis Atopic Hypersensitivity Immediate Hypersensitivity
Immunodeficiency 31c	IMD31C Candidiasis, Familial, 7 Candf7 Candidiasis, Familial Chronic Mucocutaneous, Autosomal Dominant Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome Autoimmune Enteropathy And Endocrinopathy - Susceptibility To Chronic Infections Syndrome Immunodeficiency 31c, Chronic Mucocutaneous Candidiasis, Autosomal Dominant Autosomal Dominant Chronic Mucocutaneous Familial Candidiasis Autosomal Dominant Immunodeficiency 31c Familial Candidiasis 7 Chronic Mucocutaneous Candidiasis 7 Immunodeficiency 31c, Autosomal Dominant Immunodeficiency, Type 31c, Autosomal Dominant
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991272	ATR-107	Inhibitor	99.9%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06735	IL21R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174621	Human IL21R mRNA		/	Unkown
HY-RS22573	Il21r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29091	Il21r Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990218	Anti-Mouse IL-21R Antibody (4A9)		99.96%	Unkown
HY-P992241	Anti-IL-21R Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IL21R	VGNC	VGNC:73727
Mus musculus	IL21R	MGD	MGI:1890475
Rattus norvegicus	IL21R	RGD	RGD:1304950
Felis catus	IL21R	VGNC	VGNC:67775
Canis familiaris	IL21R	VGNC	VGNC:41968
Bos taurus	IL21R	VGNC	VGNC:30142
Others	IL21R	NCBI