MRPS2 - mitochondrial ribosomal protein S2 Gene

Also Known as S2mt; CGI-91; MRP-S2; COXPD36

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51116

About MRPS2

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:135,499,965-135,504,673 (from NCBI)

This gene has 8 transcripts (splice variants), 204 orthologues and is associated with 2 phenotypes. Ubiquitous expression in kidney (RPKM 13.4), ovary (RPKM 10.7) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

MRPS2 Products (2)

mRNA	Protein	Name
NM_001371401.1	NP_001358330.1	28S ribosomal protein S2, mitochondrial
NM_016034.5	NP_057118.1	28S ribosomal protein S2, mitochondrial

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in mitochondrial ribosome assembly	IMP IMP: Inferred from mutant phenotype	29576219	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of mitochondrial small ribosomal subunit	IDA IDA: Inferred from direct assay	25838379	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRPS2 Protein Structure

Ribosomal_S2

0
100
200
296 a.a.

Protein Preferred Names	Protein Names
28S ribosomal protein S2, mitochondrial	mitochondrial small ribosomal subunit protein uS2m

Related Diseases

Diseases	Alias
Combined Oxidative Phosphorylation Deficiency 36	COXPD36
Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly	Asphyxiating Thoracic Dystrophy 2 SRTD2 Atd2 Jatd Jeune Asphyxiating Thoracic Dystrophy Jeune Syndrome 2
Hypoglycemia	Hypoglycaemia Low Blood Sugar Hypoglycaemia Nos Spontaneous Hypoglycaemia Nondiabetic Hypoglycaemia Hypoglycaemic Disorder Nos Hypoglycaemic Syndrome
Combined Oxidative Phosphorylation Deficiency
Combined Oxidative Phosphorylation Deficiency 9	COXPD9 Combined Oxidative Phosphorylation Defect Type 9 Combined Oxidative Phosphorylation Deficiency, Type 9
Brain Glioblastoma Multiforme	Brain Glioblastoma Glioblastoma Multiforme Of Brain Glioblastoma Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0501	Danofloxacin mesylate	Inhibitor	99.88%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N1423	Glycocholic acid		99.90%	Phase 3
HY-16773	Vedroprevir	Inhibitor	/	Phase 2
HY-12888	AZD5099	Inhibitor	98.40%	Phase 1

Pre-clinical Phase

Bioactive Molecules (24)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108347	CP-100356 hydrochloride	Inhibitor	99.68%	Unkown
HY-N0217	Benzoylaconine		99.92%	Unkown
HY-129987	Estradiol 17-(β-D-Glucuronide) sodium	Substrate	98.91%	Unkown
HY-W008226	Phloracetophenone		99.96%	Unkown
HY-W353102	Estradiol 17-(β-D-Glucuronide)	Substrate	99.0%	Unkown
HY-N1423A	Glycocholic acid sodium		99.24%	Unkown
HY-N1423S	Glycocholic acid-d4		99.92%	Unkown
HY-D1078	5(6)-Carboxy-2',7'-dichlorofluorescein diacetate	Substrate	97.5%	Unkown
HY-N0248	Saikosaponin B2		99.98%	Unkown
HY-D0194	5(6)-Carboxy-2',7'-dichlorofluorescein		99.03%	Unkown
HY-W585842	Estradiol 3-glucuronide	Substrate	98.00%	Unkown
HY-W013105	Sodium glycocholate hydrate, 98%		99.91%	Unkown
HY-B0947	Sulfanitran		99.67%	Unkown
HY-N1423B	Glycocholic acid hydrate		99.85%	Unkown
HY-N0406	2"-O-beta-L-galactopyranosylorientin		99.91%	Unkown
HY-N4108	Hypophyllanthin	Inhibitor	98.84%	Unkown
HY-N7755	Estradiol 3-glucuronide sodium	Substrate	98%	Unkown
HY-N1423S1	Glycocholic acid-d5		99.9%	Unkown
HY-108347A	CP-100356	Inhibitor	/	Unkown
HY-B0947S1	Sulfanitran-13C6		/	Unkown
HY-RS08678	MRPS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W702907	DM-4103	Inhibitor	/	Unkown
HY-W754548	Glycocholic acid-13C2,d4		/	Unkown
HY-B0947S	Sulfanitran-d4		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MRPS2	VGNC	VGNC:31660
Macaca mulatta	MRPS2	VGNC	VGNC:74761
Mus musculus	MRPS2	MGD	MGI:2153089
Canis familiaris	MRPS2	VGNC	VGNC:54332
Felis catus	MRPS2	VGNC	VGNC:63617
Rattus norvegicus	MRPS2	RGD	RGD:1309116
Others	MRPS2	NCBI