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CCL28 - C-C motif chemokine ligand 28 Gene

Also Known as MEC; CCK1; SCYA28

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56477

About CCL28

Cytogenetic location: 5p12 Genomic coordinates (GRCh38): 5:43,356,975-43,412,391 (from NCBI)

This gene has 4 transcripts (splice variants), 99 orthologues and 1 paralogue. Biased expression in salivary gland (RPKM 40.6), colon (RPKM 10.6) and 5 other tissues.

Summary

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

CCL28 Products (4)

mRNA	Protein	Name
NM_001301873.2	NP_001288802.1	C-C motif chemokine 28 isoform a precursor
NM_001301874.2	NP_001288803.1	C-C motif chemokine 28 isoform a precursor
NM_001301875.2	NP_001288804.1	C-C motif chemokine 28 isoform b
NM_148672.3	NP_683513.1	C-C motif chemokine 28 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables chemokine activity	IDA IDA: Inferred from direct assay	18308860	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP IMP: Inferred from mutant phenotype	12538707	GOA
involved in cell chemotaxis	IDA IDA: Inferred from direct assay	18308860	GOA
involved in cytolysis in another organism	IMP IMP: Inferred from mutant phenotype	12538707	GOA
involved in killing of cells of another organism	IMP IMP: Inferred from mutant phenotype	12538707	GOA
involved in negative regulation of leukocyte tethering or rolling	IDA IDA: Inferred from direct assay	18308860	GOA
involved in positive regulation of cell-matrix adhesion	IDA IDA: Inferred from direct assay	18308860	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12538707	GOA
colocalizes with secretory granule	IDA IDA: Inferred from direct assay	12538707	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL28 Protein Structure

IL8

0
100
127 a.a.

Protein Preferred Names	Protein Names
C-C motif chemokine 28	CC chemokine CCL28

CCL28 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CCL28	Q9NRJ3	TSC1	Homo sapiens	Q86WV8	Y2H Prey Pooling	32296183
Intra	CCL28	Q9NRJ3	TSC1	Homo sapiens	Q86WV8	Y2H Array	32296183
Intra	CCL28	Q9NRJ3	CCL17	Homo sapiens	Q92583	Filter Binding	28381538
Intra	CCL28	Q9NRJ3	CCL17	Homo sapiens	Q92583	SPR	28381538
Intra	CCL28	Q9NRJ3	PF4	Homo sapiens	P02776	Filter Binding	28381538
Intra	CCL28	Q9NRJ3	PF4	Homo sapiens	P02776	SPR	28381538
Intra	CCL28	Q9NRJ3	CCL5	Homo sapiens	P13501	Filter Binding	28381538
Intra	CCL28	Q9NRJ3	CCL5	Homo sapiens	P13501	SPR	28381538
Intra	CCL28	Q9NRJ3	PSMA3	Homo sapiens	P25788	Validated Y2H	25416956
Intra	CCL28	Q9NRJ3	PSMA3	Homo sapiens	P25788	Y2H Array	25416956
Intra	CCL28	Q9NRJ3	CXCL12	Homo sapiens	P48061	SPR	28381538
Intra	CCL28	Q9NRJ3	CXCL12	Homo sapiens	P48061	Filter Binding	28381538
Intra	CCL28	Q9NRJ3	CCL11	Homo sapiens	P51671	Filter Binding	28381538
Intra	CCL28	Q9NRJ3	DYNLT3	Homo sapiens	P51808	Y2H Prey Pooling	32296183
Intra	CCL28	Q9NRJ3	DYNLT3	Homo sapiens	P51808	Y2H Array	32296183
Intra	CCL28	Q9NRJ3	DDI1	Homo sapiens	Q8WTU0	Y2H Prey Pooling	32296183
Intra	CCL28	Q9NRJ3	DDI1	Homo sapiens	Q8WTU0	Y2H Array	32296183
Intra	CCL28	Q9NRJ3	DDI1	Homo sapiens	Q8WTU0	Y2H	21516116
Intra	CCL28	Q9NRJ3	DDI1	Homo sapiens	Q8WTU0	Y2H Array	31515488
Intra	CCL28	Q9NRJ3	CCL26	Homo sapiens	Q9Y258	Filter Binding	28381538
Intra	CCL28	Q9NRJ3	CXCL10	Homo sapiens	P02778	Filter Binding	28381538
Intra	CCL28	Q9NRJ3	CCL21	Homo sapiens	O00585	Filter Binding	28381538

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCL28 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7250	MEC/CCL28 Protein, Human	Q9NRJ3-1 (S20-Y127)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75447	MEC/CCL28 Protein, Human (His)	Q9NRJ3-1 (I23-Y127)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Pancreatitis	Mumps Pancreatitis
Acute Hemorrhagic Pancreatitis	Pancreatitis, Acute Hemorrhagic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS17249	Ccl28 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02098	CCL28 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04369	ENC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174754	Human CCL28 mRNA		/	Unkown
HY-RS23703	Ccl28 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P992198	Anti-CCL28 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CCL28	RGD	RGD:619937
Canis familiaris	CCL28	VGNC	VGNC:38890
Mus musculus	CCL28	MGD	MGI:1861731
Bos taurus	CCL28	VGNC	VGNC:26953
Macaca mulatta	CCL28	VGNC	VGNC:70815
Others	CCL28	NCBI