Limk1 - LIM domain kinase 1 Gene

Rattus norvegicus

Gene ID: 65172 | Gene type: protein coding

About Limk1

Primary_assembly 12: 22,026,672-22,060,606 forward strand.mRatBN7.2:CM026985.1

This gene has 3 transcripts (splice variants), 262 orthologues, 23 paralogues and is associated with 11 phenotypes. Biased expression in Brain (RPKM 42.9), Adrenal (RPKM 25.5) and 9 other tissues.

Summary

Predicted to enable heat shock protein binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of ubiquitin-protein transferase activity; positive regulation of cellular component organization; and protein phosphorylation. Located in several cellular components, including Golgi apparatus; axonal growth cone; and perinuclear region of cytoplasm. Orthologous to human LIMK1 (LIM domain kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Limk1 Products(1)

mRNA	Protein	Name
NM_031727.2	NP_113915.2	LIM domain kinase 1

Limk1 Protein Structure

LIM1_LIMK1

LIM2_LIMK1

PDZ

STKc_LIMK1

0
100
200
300
400
500
600
647 a.a.

Protein Preferred Names

Protein Names

LIM domain kinase 1

LIM motif-containing protein kinase 1	LIM-domain containing, protein kinase 1
LIMK-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18305	BMS-5	Inhibitor	99.51%	Unkown
HY-18304	BMS-3	Inhibitor	99.46%	Unkown
HY-122630	TH-257	Inhibitor	98.01%	Unkown
HY-19353	SR7826	Inhibitor	98.74%	Unkown
HY-120097	R-10015	Inhibitor	99.72%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-120025	CRT0105950	Inhibitor	99.91%	Unkown
HY-151539	TH470	Inhibitor	99.57%	Unkown
HY-128062	LIMK1 inhibitor BMS-4	Inhibitor	≥99.0%	Unkown
HY-N10868	8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide	Inhibitor	/	Unkown
HY-14227	LIMK-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Limk1	NCBI	NCBI:3984

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