Limk1 - LIM domain kinase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65172

About Limk1

Primary_assembly 12: 22,026,672-22,060,606 forward strand.mRatBN7.2:CM026985.1

This gene has 3 transcripts (splice variants), 262 orthologues, 23 paralogues and is associated with 11 phenotypes. Biased expression in Brain (RPKM 42.9), Adrenal (RPKM 25.5) and 9 other tissues.

Summary

Predicted to enable heat shock protein binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of ubiquitin-protein transferase activity; positive regulation of cellular component organization; and protein phosphorylation. Located in several cellular components, including Golgi apparatus; axonal growth cone; and perinuclear region of cytoplasm. Orthologous to human LIMK1 (LIM domain kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Limk1 Products (1)

mRNA Protein Name
NM_031727.2 NP_113915.2 LIM domain kinase 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in regulation of modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
25884247 RGD
involved in regulation of modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
25884247 RGD
Cellular Component GO Annotation Evidence References Source
located in axonal growth cone IDA
IDA: Inferred from direct assay
15090620 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25884247 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25884247 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15090620 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Limk1 Protein Structure

LIM1_LIMK1

LIM1_LIMK1: cd09462 (4 - 76)

LIM2_LIMK1

LIM2_LIMK1: cd09464 (83 - 137)

PDZ

PDZ: pfam00595 (164 - 254)

STKc_LIMK1

STKc_LIMK1: cd14221 (344 - 610)

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  • 500
  • 600
  • 647 a.a.
Protein Preferred Names Protein Names

LIM domain kinase 1

  • LIM motif-containing protein kinase 1

  • LIM-domain containing, protein kinase 1

  • LIMK-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-157442 GLPG3312 Inhibitor 98.63% Phase 1

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18305 BMS-5 Inhibitor 99.84% Unkown
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-18304 BMS-3 Inhibitor 99.89% Unkown
HY-122630 TH-257 Inhibitor 98.36% Unkown
HY-148061 DB1113 99.86% Unkown
HY-120097 R-10015 Inhibitor 99.72% Unkown
HY-19353 SR7826 Inhibitor 99.30% Unkown
HY-151539 TH470 Inhibitor 99.62% Unkown
HY-120025 CRT0105950 Inhibitor 99.76% Unkown
HY-128062 LIMK1 inhibitor BMS-4 Inhibitor 99.1% Unkown
HY-14227 LIMK-IN-1 Inhibitor 99.33% Unkown
HY-174229 SM311 Inhibitor / Unkown
HY-175656 MDI-117740 Inhibitor / Unkown
HY-125444 TH251 Inhibitor / Unkown
HY-P12114 S3 peptide Inhibitor / Unkown
HY-N10868 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide Inhibitor / Unkown
HY-W150222 LIMK1-IN-3 Inhibitor / Unkown
HY-174247 CPS-021 Inhibitor / Unkown
HY-169605 LIMK1 inhibitor 1 Inhibitor / Unkown
HY-111103 CZh226 Inhibitor / Unkown
HY-12659B LX7101 monohydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Limk1 NCBI NCBI:3984