Kl - Klotho Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83504

Summary

Predicted to enable Fibroblast Growth Factor binding activity and Fibroblast Growth Factor receptor binding activity. Involved in several processes, including norepinephrine biosynthetic process; response to angiotensin; and response to vitamin D. Predicted to be located in membrane. Used to study familial hyperlipidemia; hypertension; and kidney failure. Biomarker of chronic kidney disease (multiple); hypertension; retinitis pigmentosa; secondary hyperparathyroidism; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho). [provided by Alliance of Genome Resources, Apr 2022]

Kl Products (1)

mRNA Protein Name
NM_031336.2 NP_112626.1 klotho precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
20086041 RGD
involved in norepinephrine biosynthetic process IMP
IMP: Inferred from mutant phenotype
20086041 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
22891896 RGD
involved in response to angiotensin IEP
IEP: Inferred from expression pattern
11967236 RGD
involved in response to fibroblast growth factor IEP
IEP: Inferred from expression pattern
17992255 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
20631679 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

klotho

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13204A Biperiden Inhibitor 99.11% Unkown
HY-13204 Biperiden hydrochloride Inhibitor 99.90% Unkown
HY-13204B Biperiden lactate Inhibitor / Unkown
HY-13204R Biperiden hydrochloride (Standard) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-128895 KL1333 99.94% Phase 2
HY-108468 KL001 99.06% Phase 1
HY-19842 GS-9667 Agonist 98.08% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99544 Tagitanlimab Inhibitor ≥99.0% Phase 3

Pre-clinical Phase

Bioactive Molecules (29)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145597 KL-11743 99.40% Unkown
HY-D0286 Fluorol Yellow 088 ≥98.0% Unkown
HY-148185 T01-1 99.87% Unkown
HY-123972 SEC inhibitor KL-2 Inhibitor 99.49% Unkown
HY-122720 SEC inhibitor KL-1 Activator 99.58% Unkown
HY-134194 KL201 98.18% Unkown
HY-119506 KL044 99.50% Unkown
HY-172825 KL4-219A Degrader 99.85% Unkown
HY-159688 Cefditoren 98.14% Unkown
HY-164496 KL-50 Inhibitor 99.82% Unkown
HY-169087 MJBIA9836 99.67% Unkown
HY-121849 KL-1156 Inhibitor / Unkown
HY-128895A KL1333 hydrochloride Modulator / Unkown
HY-13204S Biperiden-d5 hydrochloride Inhibitor / Unkown
HY-134193 KL101 / Unkown
HY-143969S KL140061A-d4 / Unkown
HY-148185S T01-1-d5 / Unkown
HY-155972 CRM1-IN-1 Inhibitor / Unkown
HY-155972A CRM1-IN-2 / Unkown
HY-169086 KL-465 / Unkown
HY-180263 KLHDC2 ligand 4 / Unkown
HY-P12013 PEG12KL4 / Unkown
HY-RS07324 KL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10569 PIP5KL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13204AS Biperiden-d5 Inhibitor / Unkown
HY-174774 Human BMPR1B mRNA / Unkown
HY-188012 Desmethyl germinone / Unkown
HY-RS17481 Kl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23939 Kl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991302 KL-A289 Inhibitor / Unkown
HY-P990184 Anti-Mouse MHC Class II (βchain) Antibody (KL277) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kl NCBI NCBI:9365