1. PI3K/Akt/mTOR
  2. PI3K
  3. GSK2292767

GSK2292767 is a potent and selective inhibitor of PI3Kδ, with a pIC50 of 10.1. GSK2292767 showing greater than 500-fold selective over the other PI3K isoforms. GSK2292767 can be used for the research of respiratory disease.

For research use only. We do not sell to patients.

GSK2292767 Chemical Structure

GSK2292767 Chemical Structure

CAS No. : 1254036-66-2

Size Price Stock Quantity
5 mg USD 190 In-stock
10 mg USD 300 In-stock
25 mg USD 640 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

GSK2292767 is a potent and selective inhibitor of PI3Kδ, with a pIC50 of 10.1. GSK2292767 showing greater than 500-fold selective over the other PI3K isoforms. GSK2292767 can be used for the research of respiratory disease[1].

IC50 & Target[1]

PI3Kδ

10.1 (pIC50)

In Vivo

GSK2292767 exhibits high clearance (50 mL/min/kg) in vivo and low oral bioavailability (F < 2%) in a rat PK study[1].
GSK2292767 (0.01-1 μM) has no effect on QT interval, Tp‑e, or QRS and no significant risk of TdP arrhythmias in a rabbit cardiac ventricular wedge assay[1].
GSK2292767 protects against eosinophil recruitment with an ED50 of 35 μg/kg in the brown Norway rat acute OVA model of Th2 driven inflammation in the lungs of rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

512.58

Formula

C24H28N6O5S

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CS(=O)(NC1=CC(C2=CC3=C(C(C4=NC=C(CN5C[C@@H](C)O[C@@H](C)C5)O4)=C2)C=NN3)=CN=C1OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (243.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9509 mL 9.7546 mL 19.5091 mL
5 mM 0.3902 mL 1.9509 mL 3.9018 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9509 mL 9.7546 mL 19.5091 mL 48.7729 mL
5 mM 0.3902 mL 1.9509 mL 3.9018 mL 9.7546 mL
10 mM 0.1951 mL 0.9755 mL 1.9509 mL 4.8773 mL
15 mM 0.1301 mL 0.6503 mL 1.3006 mL 3.2515 mL
20 mM 0.0975 mL 0.4877 mL 0.9755 mL 2.4386 mL
25 mM 0.0780 mL 0.3902 mL 0.7804 mL 1.9509 mL
30 mM 0.0650 mL 0.3252 mL 0.6503 mL 1.6258 mL
40 mM 0.0488 mL 0.2439 mL 0.4877 mL 1.2193 mL
50 mM 0.0390 mL 0.1951 mL 0.3902 mL 0.9755 mL
60 mM 0.0325 mL 0.1626 mL 0.3252 mL 0.8129 mL
80 mM 0.0244 mL 0.1219 mL 0.2439 mL 0.6097 mL
100 mM 0.0195 mL 0.0975 mL 0.1951 mL 0.4877 mL
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GSK2292767 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GSK2292767
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HY-15280
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