1. PI3K/Akt/mTOR
  2. PI3K
  3. GSK2292767

GSK2292767 

Cat. No.: HY-15280
Handling Instructions

GSK2292767 is a potent and selective inhibitor of PI3Kδ, with a pIC50 of 10.1. GSK2292767 showing greater than 500-fold selective over the other PI3K isoforms. GSK2292767 can be used for the research of respiratory disease.

For research use only. We do not sell to patients.

GSK2292767 Chemical Structure

GSK2292767 Chemical Structure

CAS No. : 1254036-66-2

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Description

GSK2292767 is a potent and selective inhibitor of PI3Kδ, with a pIC50 of 10.1. GSK2292767 showing greater than 500-fold selective over the other PI3K isoforms. GSK2292767 can be used for the research of respiratory disease[1].

IC50 & Target[1]

PI3Kδ

10.1 (pIC50)

In Vivo

GSK2292767 exhibits high clearance (50 mL/min/kg) in vivo and low oral bioavailability (F < 2%) in a rat PK study[1].
GSK2292767 (0.01-1 μM) has no effect on QT interval, Tp‑e, or QRS and no significant risk of TdP arrhythmias in a rabbit cardiac ventricular wedge assay[1].
GSK2292767 protects against eosinophil recruitment with an ED50 of 35 μg/kg in the brown Norway rat acute OVA model of Th2 driven inflammation in the lungs of rats[1].

Molecular Weight

512.58

Formula

C₂₄H₂₈N₆O₅S

CAS No.

1254036-66-2

SMILES

CS(=O)(NC1=CC(C2=CC3=C(C(C4=NC=C(CN5C[[email protected]@H](C)O[[email protected]@H](C)C5)O4)=C2)C=NN3)=CN=C1OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

GSK2292767GSK 2292767GSK-2292767PI3KPhosphoinositide 3-kinasePI3KδrespiratorydiseaseInhibitorinhibitorinhibit

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GSK2292767
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