2. Neuronal Signaling Stem Cell/Wnt PI3K/Akt/mTOR
  3. GSK-3 Amyloid-β Cholinesterase (ChE)
  4. hAChE-IN-5

hAChE-IN-5 (compound 49) is a potent hAChE and hBuChE inhibitor with IC50 values of 0.17 μM and 0.17 μM, respectively. hAChE-IN-5 shows potent GSK3β inhibition with an IC50 value of 0.21 μM. hAChE-IN-5 is used as tau protein aggregation and Aβ1-42 self-aggregation inhibitor. hAChE-IN-5 can bind virtually with the PAS affecting Aβ aggregation, thus preventing Aβ-dependent neurotoxicity. hAChE-IN-5 can penetrate BBB and has the potential for multi-targeted anti-Alzheimer's agents research.

For research use only. We do not sell to patients.

hAChE-IN-5 Chemical Structure

hAChE-IN-5 Chemical Structure

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hAChE-IN-5 Related Antibodies

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Description

hAChE-IN-5 (compound 49) is a potent hAChE and hBuChE inhibitor with IC50 values of 0.17 μM and 0.17 μM, respectively. hAChE-IN-5 shows potent GSK3β inhibition with an IC50 value of 0.21 μM. hAChE-IN-5 is used as tau protein aggregation and Aβ1-42 self-aggregation inhibitor. hAChE-IN-5 can bind virtually with the PAS affecting Aβ aggregation, thus preventing Aβ-dependent neurotoxicity. hAChE-IN-5 can penetrate BBB and has the potential for multi-targeted anti-Alzheimer's agents research[1].

Molecular Weight

444.12

Formula

C18H12Br2N4
SMILES

BrC1=CC=C(C2=C3C(NN=C3N)=NC(C4=CC=C(Br)C=C4)=C2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hAChE-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hAChE-IN-5GSK-3Amyloid-βCholinesterase (ChE)Glycogen synthase kinase-3Glycogen synthase kinase 3β-amyloid peptideAβAbetahAChEhBuChEGSK3βtau proteinaggregationAβ1-42self-aggregationPASneurotoxicityBBBAlzheimerInhibitorinhibitorinhibit

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