hCAII-IN-2
hCAII-IN-2 (Compound 11f) is a cytosolic human carbonic anhydrase (hCA) inhibitor with Ki values of 261.4, 3.8, 19.6 and 45.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively.
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- CAS No.: 2408599-78-8
- Formule: C25H18ClN5O4S
- Masse moléculaire:519.96
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
Ki: 3.8 nM (hCA II), 19.6 nM (hCA IX), 45.2 nM (hCA XII), 261.4 nM (hCA I)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
2.71 μM
Compound: 11f
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs under hypoxia condition by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs under hypoxia condition by MTT assay
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[PMID: 31901743] |
| HeLa | IC50 |
8.8 μM
Compound: 11f
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs under normaxia condition by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs under normaxia condition by MTT assay
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[PMID: 31901743] |
| WI-38 | IC50 |
22.02 μM
Compound: 11f
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Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 31901743] |
Chemical Information
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CAS No. 2408599-78-8
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Masse moléculaire 519.96
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Formule C25H18ClN5O4S
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SMILES
NS(=O)(C1=CC=C(C=C1)N2C=C(C3=C2N=CN=C3NC4=C(C=CC=C4)C(O)=O)C5=CC=C(C=C5)Cl)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCAII-IN-2 Related Classifications
HY-146355 Related Classifications
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