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Cat. No.: HY-147665

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hCAIX-IN-7

hCAIX-IN-7 (compound 6c) is a potent and selective hCAIX inhibitor with K_Is of >10000, >10000, 43.0, 410.6 nM for hCAI, hCAII, hCAIV, hCAIX, respectively.

For research use only. We do not sell to patients.

CAS No.: 2451479-58-4
Formula: C₁₈H₁₂FNO₃
Molecular Weight:309.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

hCAIX-IN-7 Chemical Structure

CAS No.: 2451479-58-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

hCAIX-IN-7 (compound 6c) is a potent and selective hCAIX inhibitor with K_Is of >10000, >10000, 43.0, 410.6 nM for hCAI, hCAII, hCAIV, hCAIX, respectively^[1].

IC₅₀ & Target

K_I: >10000 nM (hCAI); >10000 nM (hCAII); 43.0 nM (hCAIV); 410.6 nM (hCAIX)^[1]

All Carbonic Anhydrase Isoforms :

Chemical Information

CAS No. 2451479-58-4
Molecular Weight 309.29
Formula C₁₈H₁₂FNO₃
SMILES

O=C(NC1=CC2=C(OC(C=C2)=O)C=C1)/C=C/C3=CC=CC(F)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Swain B, et al. New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation. Bioorg Med Chem. 2020 Aug 1;28(15):115586. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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hCAIX-IN-7

All Carbonic Anhydrase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

hCAIX-IN-7 Related Classifications

HY-147665 Related Classifications