HMC-B17
HMC-B17 is a selective, orally bioavailable HPK1 inhibitor (IC50 = 1.39 nM) that potentiates anti-PD-L1 efficacy. HMC-B17 potently enhances the IL-2 secretion in Jurkat cells (EC50 = 11.56 nM). HMC-B17 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2935913-83-8
- Formula: C27H29N3O2
- Molecular Weight:427.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All MAP4K Isoforms
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Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BEAS-2B | IC50 |
>8 μM
Compound: F03; HMC-B17
|
Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by Cell Titer Glo assay
|
[PMID: 38350360] |
| Jurkat | IC50 |
>8 μM
Compound: F03; HMC-B17
|
Cytotoxicity against human Jurkat cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human Jurkat cells incubated for 48 hrs by Cell Titer Glo assay
|
[PMID: 38350360] |
| L02 | IC50 |
>8 μM
Compound: F03; HMC-B17
|
Cytotoxicity against human L02 cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human L02 cells incubated for 48 hrs by Cell Titer Glo assay
|
[PMID: 38350360] |
| MCF-10A | IC50 |
>8 μM
Compound: F03; HMC-B17
|
Cytotoxicity against human MCF-10A cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human MCF-10A cells incubated for 48 hrs by Cell Titer Glo assay
|
[PMID: 38350360] |
| WRL68 | IC50 |
>8 μM
Compound: F03; HMC-B17
|
Cytotoxicity against human WRL68 cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human WRL68 cells incubated for 48 hrs by Cell Titer Glo assay
|
[PMID: 38350360] |
Chemical Information
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CAS No. 2935913-83-8
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Molecular Weight 427.54
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Formula C27H29N3O2
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SMILES
COC1=C(C=C(C=C1)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)C5CCN(C)CC5)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)