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Cat. No.: HY-157838

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HMC-B17

HMC-B17 is a selective, orally bioavailable HPK1 inhibitor (IC₅₀ = 1.39 nM) that potentiates anti-PD-L1 efficacy. HMC-B17 potently enhances the IL-2 secretion in Jurkat cells (EC₅₀ = 11.56 nM). HMC-B17 can be used for the research of cancer.

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CAS No.: 2935913-83-8
화학식: C₂₇H₂₉N₃O₂
분자량:427.54

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HMC-B17 Chemical Structure

CAS No.: 2935913-83-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All MAP4K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BEAS-2B	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]
Jurkat	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human Jurkat cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human Jurkat cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]
L02	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human L02 cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human L02 cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]
MCF-10A	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human MCF-10A cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human MCF-10A cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]
WRL68	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human WRL68 cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human WRL68 cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]

Chemical Information

CAS No. 2935913-83-8
분자량 427.54
화학식 C₂₇H₂₉N₃O₂
SMILES

COC1=C(C=C(C=C1)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)C5CCN(C)CC5)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zeng S, et al. Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody. Eur J Med Chem. 2024 Mar 5;267:116206. [Content Brief]

Calculators

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
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수량:
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HMC-B17

All MAP4K Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HMC-B17 Related Classifications

HY-157838 Related Classifications