1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. TRP Channel
    Endogenous Metabolite
  3. Hydroxy-α-sanshool

Hydroxy-α-sanshool 

Cat. No.: HY-N6825 Purity: 99.13%
Handling Instructions

Hydroxy-​α-​sanshool is an alkylamide isolated from pepper, acts as a TRPA1 covalent and TRPV1 non-covalent agonist, with EC50s of 69 and 1.1 µM, respectively.

For research use only. We do not sell to patients.

Hydroxy-α-sanshool Chemical Structure

Hydroxy-α-sanshool Chemical Structure

CAS No. : 83883-10-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 325 In-stock
Estimated Time of Arrival: December 31
Liquid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 325 In-stock
Estimated Time of Arrival: December 31
Liquid
5 mg USD 295 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Hydroxy-​α-​sanshool is an alkylamide isolated from pepper, acts as a TRPA1 covalent and TRPV1 non-covalent agonist, with EC50s of 69 and 1.1 µM, respectively[1].

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

263.38

Formula

C₁₆H₂₅NO₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (379.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7968 mL 18.9840 mL 37.9680 mL
5 mM 0.7594 mL 3.7968 mL 7.5936 mL
10 mM 0.3797 mL 1.8984 mL 3.7968 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (9.49 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (9.49 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.37%

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Product Name:
Hydroxy-α-sanshool
Cat. No.:
HY-N6825
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