2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. TRP Channel Endogenous Metabolite
  4. Hydroxy-α-sanshool

Hydroxy-α-sanshool 

Cat. No.: HY-N6825 Purity: 99.57%
COA Handling Instructions

Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 µM, respectively. Hydroxy-α-sanshool can be used for pain research.

For research use only. We do not sell to patients.

Hydroxy-α-sanshool Chemical Structure

Hydroxy-α-sanshool Chemical Structure

CAS No. : 83883-10-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 325 In-stock
Liquid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 325 In-stock
Liquid
5 mg USD 295 In-stock
10 mg USD 480 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Hydroxy-α-sanshool Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Hydroxy-α-sanshool

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Description

Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 µM, respectively. Hydroxy-α-sanshool can be used for pain research[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Hydroxy-α-sanshool (0-10 mM; 20 s) induces inward currents in cultured DRG neuron[2].
Hydroxy-α-sanshool (1 mM; 0-1 min) increases intracellular Ca2+ in cultured DRG neuron[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hydroxy-α-sanshool Related Antibodies

Cell Viability Assay[2]

Cell Line: Dorsal root ganglion (DRG) neurons
Concentration: 0-10 mM
Incubation Time: 20 s
Result: Induced small but robust inward currents for DRG neuron with an EC50 of 66.2 μM.

Cell Viability Assay[2]

Cell Line: Dorsal root ganglion (DRG) neurons
Concentration: 1 mM
Incubation Time: 0-1 min
Result: Led to an intracellular Ca2+ increase in the majority of DRG neurons tested (98 of 100).
In Vivo

Hydroxy-α-sanshool (intradermal injection; 4 mg per mouse; once) shows paw-licking response in wild-type and TRPV1-deficient mice[2].
Hydroxy-α-sanshool (1 mM) is markedly aversive to WT mice, but in TRPV1 KO mice, the aversion is almost entirely eliminated (P<0.001)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type and TRPV1-deficient mice[2]
Dosage: 4 mg per mouse
Administration: Intradermal injection; 4 mg per mouse; once
Result: Reduced paw-licking response in TRPV1-deficient mice (160 times, P < 0.05).
Showed paw-licking response in wild-type mice (mean 284.8 times) in 20 min.
Molecular Weight

263.38

Appearance

Viscous liquid

Formula

C16H25NO2
CAS No.
SMILES

C/C=C/C=C/C=C\CC/C=C/C(NCC(C)(O)C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (379.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7968 mL 18.9840 mL 37.9680 mL
5 mM 0.7594 mL 3.7968 mL 7.5936 mL
10 mM 0.3797 mL 1.8984 mL 3.7968 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (9.49 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (9.49 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.90 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.57%

COA (240 KB) LCMS (91 KB)

Handling Instructions (2659 KB)
References
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Hydroxy-α-sanshool Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

Hydroxy-α-sanshool83883-10-7TRP ChannelEndogenous MetaboliteTransient receptor potential channelspaindorsal root ganglion neuronsDRG neuronsInhibitorinhibitorinhibit

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