FPS-ZM1
Based on 63 publication(s) in Google Scholar
FPS-ZM1 is a high-affinity and BBB-permeable RAGE inhibitor with a Ki of 25 nM.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 945714-67-0
- Formula: C20H22ClNO
- Molecular Weight:327.85
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
Publications Citing Use of MedChemExpress (MCE) FPS-ZM1
More- Nat Commun. 2025 Aug 9;16(1):7368. [Abstract]
- Nat Commun. 2025 Jul 24;16(1):6807. [Abstract]
- Adv Sci (Weinh). 2026 Jan 20:e16355. [Abstract]
- Adv Sci (Weinh). 2025 Jun 25:e03722. [Abstract]
- Exp Hematol Oncol. 2024 Jun 26;13(1):63. [Abstract]
- Theranostics. 2020 Apr 27;10(13):5687-5703 [Abstract]
- Nano Today. 2024 Aug.
- Diabetologia. 2020 May;63(5):987-1001. [Abstract]
- Cancer Lett. 2025 Sep 4:218017. [Abstract]
- J Neuroinflammation. 2020 Oct 9;17(1):295. [Abstract]
- Int J Biol Sci. 2024 Jan 1;20(2):784-800. [Abstract]
- Nano Res. 04 March 2022.
- Phytomedicine. 2025 Dec 26:150:157744. [Abstract]
- Phytomedicine. 2024 Jul:129:155654. [Abstract]
- Brain Behav Immun. 2017 Jan:59:322-332. [Abstract]
- Biomed Pharmacother. 2024 Jul 15:177:117111. [Abstract]
- Stem Cell Res Ther. 2024 Nov 15;15(1):431. [Abstract]
- Cell Rep. 2026 Jan 22;45(2):116897. [Abstract]
- Arch Toxicol. 2025 Dec 8. [Abstract]
- Cell Rep. 2024 May 10;43(5):114226. [Abstract]
- Cell Rep. 2022 Sep 20;40(12):111401. [Abstract]
- NPJ Regen Med. 2020 Oct 30;5(1):19. [Abstract]
- J Agric Food Chem. 2025 Aug 27;73(34):21566-21577. [Abstract]
- J Clin Immunol. 2025 Nov 15;45(1):160. [Abstract]
- J Invest Dermatol. 2022 Oct;142(10):2591-2602.e8. [Abstract]
- Biochem Pharmacol. 2020 May;175:113849. [Abstract]
- Cell Prolif. 2018 Oct;51(5):e12471 [Abstract]
- J Ethnopharmacol. 2026 May 10:362:121366. [Abstract]
- J Ethnopharmacol. 2025 Oct 27:356:120818. [Abstract]
- Chem Biol Interact. 2021 Oct 1:348:109625. [Abstract]
- Cells. 2025 Mar 8;14(6):397. [Abstract]
- Int Immunopharmacol. 2025 Jun 18:161:115112. [Abstract]
- Int Immunopharmacol. 2025 Feb 3:149:114192. [Abstract]
- Eur J Pharm Sci. 2024 Jun 10:106829. [Abstract]
- Neuropharmacology. 2020 Dec 1;180:108304. [Abstract]
- Mol Neurobiol. 2025 Jun;62(6):7183-7204. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Jan 6:167656. [Abstract]
- Exp Neurol. 2024 Aug 1:114912. [Abstract]
- Drug Dev Res. 2024 Jun;85(4):e22219. [Abstract]
- J Inflamm Res. 2024 Oct 1:17:6935-6954. [Abstract]
- iScience. 2022 Aug 4;25(9):104872. [Abstract]
- Sci Rep. 2025 Jul 1;15(1):21506. [Abstract]
- Sci Rep. 2023 Nov 9;13(1):19440. [Abstract]
- ACS Chem Neurosci. 2021 Jan 6;12(1):63-78. [Abstract]
- Cell Signal. 2026 Jul:143:112490. [Abstract]
- Cytokine. 2024 May 14:180:156635. [Abstract]
- Food Chem Toxicol. 2024 Jun 11:190:114762. [Abstract]
- J Immunol. 2020 May 1;204(9):2589-2599. [Abstract]
- BMC Endocr Disord. 2024 Aug 29;24(1):164. [Abstract]
- Oral Dis. 2025 Oct 27. [Abstract]
- J Nat Med. 2021 Jun;75(3):675-681. [Abstract]
- Immunol Invest. 2022 Jul;51(5):1243-1256. [Abstract]
- Biochim Biophys Acta Gen Subj. 2025 Oct 22;1869(12):130873. [Abstract]
- Biochim Biophys Acta Gen Subj. 2024 Jun 1:130650. [Abstract]
- Neurosci Lett. 2018 Nov 1:686:33-40. [Abstract]
- In Vitro Cell Dev Biol Anim. 2023 Apr;59(4):289-299. [Abstract]
- Res Sq. 2024 Oct 15.
- bioRxiv. 2024 May 14.
- SSRN. 2023 Oct 18.
- Research Square Print. 2023 Feb 8.
- Evid Based Complement Alternat Med. 2022 Feb 25:2022:7781910. [Abstract]
- Oxid Med Cell Longev. 2021 Aug 2;2021:9993240. [Abstract]
- Research Square Preprint. 2020 Sep.
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WB
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WB
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IF
Biological Activity
Ki: 25 nM (RAGE)[1]
FPS-ZM1 inhibits Aβ/RAGE binding in CHO cells with approximately 2-fold greater affinity than its parent molecule, FPS2. FPS-ZM1 inhibits binding of other known RAGE ligands to sRAGE, including S100 calcium-binding protein B and amphoterin. FPS-ZM1 is more effective than FPS2 in reducing Aβ40-induced increases inBACE1 mRNA and protein levels and the generation of sAPPβ, an APP cleavage product of BACE1 indicative of BACE1 activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 945714-67-0
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Appearance Solid
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Molecular Weight 327.85
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Formula C20H22ClNO
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Color White to off-white
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SMILES
ClC1=CC=C(C(N(C2CCCCC2)CC3=CC=CC=C3)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (63)
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Journal Impact Factor
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Most Recent
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Nat Commun
Design of Ig-like binders targeting α-synuclein fibril for mitigating its pathological activities. [Abstract]2025 Aug 9;16(1):7368. PMID: 40783395 -
Nat Commun
Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice. [Abstract]2025 Jul 24;16(1):6807. PMID: 40707439 -
Adv Sci (Weinh)
OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα. [Abstract]2026 Jan 20:e16355. PMID: 41560298 -
Adv Sci (Weinh)
Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia-Reperfusion Injury. [Abstract]2025 Jun 25:e03722. PMID: 40557450 -
Exp Hematol Oncol
cGAS-ISG15-RAGE axis reprogram necroptotic microenvironment and promote lymphatic metastasis in head and neck cancer. [Abstract]2024 Jun 26;13(1):63. PMID: 38926796 -
Theranostics
2020 Apr 27;10(13):5687-5703 PMID: 32483412 -
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Diabetologia
Extracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability. [Abstract]2020 May;63(5):987-1001. PMID: 32072192 -
Cancer Lett
S100A4 facilitates radiation-induced tumor repopulation by driving polyploid giant cancer cells budding. [Abstract]2025 Sep 4:218017. PMID: 40914345 -
J Neuroinflammation
Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury. [Abstract]2020 Oct 9;17(1):295. PMID: 33036632 -
Int J Biol Sci
Inhibition of the HMGB1/RAGE axis protects against cisplatin-induced ototoxicity via suppression of inflammation and oxidative stress. [Abstract]2024 Jan 1;20(2):784-800. PMID: 38169643 -
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Phytomedicine
Jinlida ameliorates diabetic kidney disease via gut microbiota-dependent production of pyridoxamine targeting renal AGEs/RAGE and TGF-β pathways. [Abstract]2025 Dec 26:150:157744. PMID: 41485293 -
Phytomedicine
Protective effects of Wenqingyin on sepsis-induced acute lung injury through regulation of the receptor for advanced glycation end products pathway. [Abstract]2024 Jul:129:155654. PMID: 38723525 -
Brain Behav Immun
Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1. [Abstract]2017 Jan:59:322-332. PMID: 27647532 -
Biomed Pharmacother
Bongkrekic acid alleviates airway inflammation via breaking the mPTP/mtDAMPs/RAGE feedback loop in a steroid-insensitive asthma model. [Abstract]2024 Jul 15:177:117111. PMID: 39013220 -
Stem Cell Res Ther
AGEs impair osteogenesis in orthodontic force-induced periodontal ligament stem cells through the KDM6B/Wnt self-reinforcing loop. [Abstract]2024 Nov 15;15(1):431. PMID: 39548506 -
Cell Rep
A monoclonal antibody targeting the C-terminal of α-synuclein fibrils mitigates pathology in a Parkinson's disease model. [Abstract]2026 Jan 22;45(2):116897. PMID: 41575853 -
Arch Toxicol
Mechanism of liver fibrosis induced by life-long triclosan exposure in offspring rats: an adverse outcome pathway framework validated by in vivo and in vitro experiments. [Abstract]2025 Dec 8. PMID: 41361110 -
Cell Rep
Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus. [Abstract]2024 May 10;43(5):114226. PMID: 38733586 -
Cell Rep
Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia. [Abstract]2022 Sep 20;40(12):111401. PMID: 36130498 -
NPJ Regen Med
2020 Oct 30;5(1):19. PMID: 33298919 -
J Agric Food Chem
Molecular Mechanism of Glycation Structure-Mediated Immune Recognition and Sensitization by Typical Milk Allergens. [Abstract]2025 Aug 27;73(34):21566-21577. PMID: 40801482 -
J Clin Immunol
S100A4 Induces Neutrophilic Inflammation in Chronic Rhinosinusitis with Nasal Polyps via TLR4 Pathway. [Abstract]2025 Nov 15;45(1):160. PMID: 41240201 -
J Invest Dermatol
Advanced Glycation End Products Promote Melanogenesis by Activating NLRP3 Inflammasome in Human Dermal Fibroblasts. [Abstract]2022 Oct;142(10):2591-2602.e8. PMID: 35421403 -
Biochem Pharmacol
Thrombin/PAR-1 activation induces endothelial damages via NLRP1 inflammasome in gestational diabetes. [Abstract]2020 May;175:113849. PMID: 32059841 -
Cell Prolif
Blockade of receptors of advanced glycation end products ameliorates diabetic osteogenesis of adipose-derived stem cells through DNA methylation and Wnt signalling pathway. [Abstract]2018 Oct;51(5):e12471 PMID: 30014569
FPS-ZM1 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2018 Oct;51(5):e12471 [Abstract]
The effect of FPS-ZM1 treatment on osteogenic potential of adipose-derived stem cells (ASCs). FPS-ZM1 blocks RAGE in the FPS and advanced glycation end products (AGEs)+FPS-ZM1 groups.
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J Ethnopharmacol
Taohong Siwu decoction and its components regulate the M1/M2 polarization of macrophages to alleviate inflammatory injury in sepsis via the RAGE. [Abstract]2026 May 10:362:121366. PMID: 41692111 -
J Ethnopharmacol
Sishen pill alleviates DSS induced colitis through AGE/RAGE/NLRP3 pathway based on transcriptomics analysis. [Abstract]2025 Oct 27:356:120818. PMID: 41161619 -
Chem Biol Interact
Catalpol ameliorates endothelial dysfunction and inflammation in diabetic nephropathy via suppression of RAGE/RhoA/ROCK signaling pathway. [Abstract]2021 Oct 1:348:109625. PMID: 34416245 -
Cells
2025 Mar 8;14(6):397. PMID: 40136646 -
Int Immunopharmacol
TLR3-mediated NET formation and macrophage activation in acute liver failure: Targeting IL-36 signaling to attenuate inflammatory drivers. [Abstract]2025 Jun 18:161:115112. PMID: 40554259 -
Int Immunopharmacol
Inhibiting HMGB1/AGER/NF-κB pathway prevents pro-inflammatory microglia polarization and protect photoreceptors in retinitis pigmentosa. [Abstract]2025 Feb 3:149:114192. PMID: 39904032 -
Eur J Pharm Sci
CYP2E1 mediated advanced oxidation protein products exacerbate acetaminophen induced drug-derived liver injury in vitro and in vivo. [Abstract]2024 Jun 10:106829. PMID: 38866111 -
Neuropharmacology
RP1, a RAGE antagonist peptide, can improve memory impairment and reduce Aβ plaque load in the APP/PS1 mouse model of Alzheimer's disease. [Abstract]2020 Dec 1;180:108304. PMID: 32931813 -
Mol Neurobiol
The Receptor for Advanced Glycation End-products in the Mouse Anterior Cingulate Cortex is Involved in Neuron‒Astrocyte Coupling in Chronic Inflammatory Pain and Anxiety Comorbidity. [Abstract]2025 Jun;62(6):7183-7204. PMID: 39863743 -
Biochim Biophys Acta Mol Basis Dis
Renal tubular S100A7a impairs fatty acid oxidation and exacerbates renal fibrosis via both intracellular and extracellular pathway. [Abstract]2025 Jan 6:167656. PMID: 39778778 -
Exp Neurol
2024 Aug 1:114912. PMID: 39097075 -
Drug Dev Res
Oxymatrine attenuates sepsis-induced inflammation and organ injury via inhibition of HMGB1/RAGE/NF-κB signaling pathway. [Abstract]2024 Jun;85(4):e22219. PMID: 38845211 -
J Inflamm Res
The AGEs/RAGE Signaling Pathway Regulates NLRP3-Mediated Neuronal Pyroptosis After MCAO Injury in Lepr-/- Obese Rats. [Abstract]2024 Oct 1:17:6935-6954. PMID: 39372588 -
iScience
Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE. [Abstract]2022 Aug 4;25(9):104872. PMID: 36034219 -
Sci Rep
S100A8 regulated by estrogen improves injured endometrial epithelium reconstruction by promoting tight junction formation and stromal cell transformation. [Abstract]2025 Jul 1;15(1):21506. PMID: 40596550 -
Sci Rep
Dysfunctional TLR1 reduces the therapeutic efficacy of chemotherapy by attenuating HMGB1-mediated antitumor immunity in locally advanced colorectal cancer. [Abstract]2023 Nov 9;13(1):19440. PMID: 37945630 -
ACS Chem Neurosci
FPS-ZM1 Alleviates Neuroinflammation in Focal Cerebral Ischemia Rats via Blocking Ligand/RAGE/DIAPH1 Pathway. [Abstract]2021 Jan 6;12(1):63-78. PMID: 33300334 -
Cell Signal
Molecular mechanism of S100P promotes hepatocellular carcinoma by regulating MYBL2-mediated transcription of AURKB. [Abstract]2026 Jul:143:112490. PMID: 41856224 -
Cytokine
Chrysin mitigated neuropathic pain and peripheral sensitization in knee osteoarthritis rats by repressing the RAGE/PI3K/AKT pathway regulated by HMGB1. [Abstract]2024 May 14:180:156635. PMID: 38749277 -
Food Chem Toxicol
The role of HMGB1 on SiC NPs-induced inflammation response in lung epithelial-macrophage co-culture system. [Abstract]2024 Jun 11:190:114762. PMID: 38871110 -
J Immunol
Proinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape. [Abstract]2020 May 1;204(9):2589-2599. PMID: 32198140 -
BMC Endocr Disord
FPS-ZM1 attenuates the deposition of lipid in the liver of diabetic mice by sterol regulatory element binding protein-1c. [Abstract]2024 Aug 29;24(1):164. PMID: 39210356 -
Oral Dis
2025 Oct 27. PMID: 41146398 -
J Nat Med
Identification of pheophorbide a as an inhibitor of receptor for advanced glycation end products in Mallotus japonicus. [Abstract]2021 Jun;75(3):675-681. PMID: 33625682 -
Immunol Invest
2022 Jul;51(5):1243-1256. PMID: 34018452 -
Biochim Biophys Acta Gen Subj
P2X7 receptor contributes to DNA damage repair and acquisition of malignant phenotypes in irradiated human glioblastoma cells. [Abstract]2025 Oct 22;1869(12):130873. PMID: 41135637 -
Biochim Biophys Acta Gen Subj
Involvement of RAGE in radiation-induced acquisition of malignant phenotypes in human glioblastoma cells. [Abstract]2024 Jun 1:130650. PMID: 38830560 -
Neurosci Lett
TLR4 signaling pathway mediates the LPS/ischemia-induced expression of monocytechemotactic protein-induced protein 1 in microglia. [Abstract]2018 Nov 1:686:33-40. PMID: 30179651
FPS-ZM1 purchased from MedChemExpress. Usage Cited in: Neurosci Lett. 2018 Nov 1:686:33-40. [Abstract]
Western Blot analyses show the protein expression of MCPIP1 after the treatment of PBS and LPS (with TAK-242, C29, FPS-ZM1).
FPS-ZM1 purchased from MedChemExpress. Usage Cited in: Neurosci Lett. 2018 Nov 1:686:33-40. [Abstract]
Images show the expression of MCPIP1 after the treatment of of PBS and LPS (with TAK-242, C29, FPS-ZM1).
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In Vitro Cell Dev Biol Anim
Macrophage pyroptosis promotes synovial fibrosis through the HMGB1/TGF- β1 axis: an in vivo and in vitro study. [Abstract]2023 Apr;59(4):289-299. PMID: 37195554 -
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Evid Based Complement Alternat Med
Resveratrol Inhibits High Glucose-Induced H9c2 Cardiomyocyte Hypertrophy and Damage via RAGE-Dependent Inhibition of the NF- κ B and TGF- β 1/Smad3 Pathways. [Abstract]2022 Feb 25:2022:7781910. PMID: 35251212 -
Oxid Med Cell Longev
Recombinant High-Mobility Group Box 1 (rHMGB1) Promotes NRF2-Independent Mitochondrial Fusion through CXCR4/PSMB5-Mediated Drp1 Degradation in Endothelial Cells. [Abstract]2021 Aug 2;2021:9993240. PMID: 34394840 -
Solvent & Solubility
DMSO : 58.33 mg/mL (177.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.63 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.63 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocol
Human sRAGE is immobilized (10 μg/mL) overnight at 4°C in 96-well microtiter plates and blocked with 3% bovine serum albumin. 125I-labeled Aβ40, HMGB1, or S100B at 5 nM in the absence and presence of various concentrations of FPS2 or FPS-ZM1 (10 to 1,000 nM) is added to the wells containing immobilized sRAGE and incubated for 1 hour at room temperature in PBS. Wells are washed with cold PBS to remove unbound radiolabeled ligands, and the radioactivity is analyzed[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
To determine whether FPS2 and FPS-ZM1 are toxic to CHO cells, the cells are treated for 72 hours with different concentrations of inhibitors ranging from 10 nM to 10 μM. The cellular toxicity is determined using the WST-8 Assay Kit[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Rats: Starting from 1 week before intrahippocampal injection, FZM1 and AGEs+FZM1 rats are intraperitoneally injected with FPS-ZM1 (1 mg/kg/d at a volume of 2 mL) for 4 weeks; rats in the AGEs and the control groups are intraperitoneally injected with normal saline with the same volume for 4 weeks. Three weeks after AGEs intrahippocampal injection, the escape latency time of rats is assayed with Morris water maze test, and then all rats are sacrificed[2].
Mice: FPS2 or FPS-ZM1 are administered i.v. (1 mg/kg) via the femoral vein and arterial blood samples (30 μL) collected at 1, 5, 10, 15, and 20 minutes via the cannulated femoral artery. Plasma is separated by centrifugation at 4°C and immediately stored at -80°C until analysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Portuguese - PT (537 KB)
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Handling Instructions (2659 KB)
References
[1]. Deane R, et al. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012 Apr;122(4):1377-92. [Content Brief]
[2]. Hong Y, et al. Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus. Neurochem Res. 2016 May;41(5):1192-9. [Content Brief]
[3]. Lian YJ, et al. Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1. Brain Behav Immun. 2017 Jan;59:322-332. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0502 mL | 15.2509 mL | 30.5018 mL | 76.2544 mL |
| 5 mM | 0.6100 mL | 3.0502 mL | 6.1004 mL | 15.2509 mL | |
| 10 mM | 0.3050 mL | 1.5251 mL | 3.0502 mL | 7.6254 mL | |
| 15 mM | 0.2033 mL | 1.0167 mL | 2.0335 mL | 5.0836 mL | |
| 20 mM | 0.1525 mL | 0.7625 mL | 1.5251 mL | 3.8127 mL | |
| 25 mM | 0.1220 mL | 0.6100 mL | 1.2201 mL | 3.0502 mL | |
| 30 mM | 0.1017 mL | 0.5084 mL | 1.0167 mL | 2.5418 mL | |
| 40 mM | 0.0763 mL | 0.3813 mL | 0.7625 mL | 1.9064 mL | |
| 50 mM | 0.0610 mL | 0.3050 mL | 0.6100 mL | 1.5251 mL | |
| 60 mM | 0.0508 mL | 0.2542 mL | 0.5084 mL | 1.2709 mL | |
| 80 mM | 0.0381 mL | 0.1906 mL | 0.3813 mL | 0.9532 mL | |
| 100 mM | 0.0305 mL | 0.1525 mL | 0.3050 mL | 0.7625 mL |