RCM-1
Based on 7 publication(s) in Google Scholar
RCM-1 is a forkhead box M1 (FOXM1) inhibitor with an EC50 of 0.72 μM in U2OS cells. RCM-1 blocks the nuclear localization and increased the proteasomal degradation of FOXM1. RCM-1 can be used for asthma and other chronic airway diseases research.
For research use only. We do not sell to patients.
- Purity: 98.56%
- CAS No.: 339163-65-4
- Formula: C20H12N2OS4
- Molecular Weight:424.58
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) RCM-1
More- Redox Biol. 2026 May:92:104108. [Abstract]
- Adv Healthc Mater. 2026 Jan 4:e03543. [Abstract]
- Cell Death Discov. 2022 Aug 9;8(1):354. [Abstract]
- Mol Syst Biol. 2025 Sep;21(9):1263-1281. [Abstract]
- Transl Oncol. 2025 Feb 21:54:102327. [Abstract]
- Cell Signal. 2024 Dec:124:111467. [Abstract]
- Acta Biochim Biophys Sin (Shanghai). 2024 Apr 25;56(4):621-633. [Abstract]
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Biological Activity
FOXM1[1].
RCM-1 blocks the nuclear localization and increased the proteasomal degradation of FOXM1, a transcription factor critical for the differentiation of goblet cells from airway progenitor cells. In cultured airway epithelial cells, RCM-1 reduces IL-13 and STAT6 signaling and prevented the expression of the STAT6 target genes Spdef and Foxa3, which are key transcriptional regulators of goblet cell differentiation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 339163-65-4
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Appearance Solid
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Molecular Weight 424.58
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Formula C20H12N2OS4
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Color Off-white to gray
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SMILES
N#CC1=C(C2=CC=CS2)C=C(C3=CC=CS3)N=C1SCC(C4=CC=CS4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (7)
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Journal Impact Factor
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Most Recent
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Redox Biol
SIRT3-mediated deacetylation of FoxM1 prevents pulmonary fibrosis via modulating the activation of pulmonary fibroblasts. [Abstract]2026 May:92:104108. PMID: 41797045
RCM-1 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 May:92:104108. [Abstract]
Western blot analysis of nuclear FoxM1, CTHRC1, α-SMA, and Collagen I expression in TGF-β1-treated pulmonary fibroblasts accompany with or without RCM-1 (1 mg/kg, i.p.)treatment.
RCM-1 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 May:92:104108. [Abstract]
EdU assay for the proliferation of TGF-β1-treated pulmonary fibroblasts accompany with or without RCM-1 (1 mg/kg, i.p.)treatment.
RCM-1 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 May:92:104108. [Abstract]
Hematoxylin–eosin (H&E) and masson's trichrome staining for the lung tissues from BLM-treated mice injected with or without RCM-1 (1 mg/kg, i.p.).
RCM-1 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 May:92:104108. [Abstract]
The survival of BLM-treated mice injected with or without RCM-1 (1 mg/k, i.p.).
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Adv Healthc Mater
Bioinspired Microgel Assembly of Liver-Derived Decellularized Extracellular Matrix Enhances Dentin-Pulp Regeneration via Stemness Awakening. [Abstract]2026 Jan 4:e03543. PMID: 41486849 -
Cell Death Discov
Down-regulated m6A reader FTO destabilizes PHF1 that triggers enhanced stemness capacity and tumor progression in lung adenocarcinoma. [Abstract]2022 Aug 9;8(1):354. PMID: 35945194 -
Mol Syst Biol
2025 Sep;21(9):1263-1281. PMID: 40588571 -
Transl Oncol
Thiostrepton suppresses intrahepatic cholangiocarcinoma progression via FOXM1-mediated tumor-associated macrophages reprogramming. [Abstract]2025 Feb 21:54:102327. PMID: 39986191 -
Cell Signal
Fangchinoline inhibits metastasis and reduces inflammation-induced epithelial-mesenchymal transition by targeting the FOXM1-ADAM17 axis in hepatocellular carcinoma. [Abstract]2024 Dec:124:111467. PMID: 39393566 -
Acta Biochim Biophys Sin (Shanghai)
Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis. [Abstract]2024 Apr 25;56(4):621-633. PMID: 38516704
Solvent & Solubility
DMSO : 16.67 mg/mL (39.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
Rd76-9 rhabdomyosarcoma, B16-FlO melanoma, H2122 lung adenocarcinoma, 4T1 breast carcinoma, MyC-CaP prostate carcinoma and KPC-2 pancreatic carcinoma cells are seeded in 6-well plates and incubated overnight. The cells are treated with 20 μM concentration of RCM-1 for 24, 48 and 72 h and cell growth is analyzed by counting alive cells using trypan blue. Cells treated with DMSO are used as controls[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Mice[1]
Mouse Rd76-9 rhabdomyosarcoma cells (1×106 cells) are injected intramuscularly in the flanks of C56Bl/6J mice (n=8 mice per group). Seven days after the tumor cells inoculation, 40 μL of either Vehicle (DMSO) or RCM-1 (20 mg/kg body weight) are injected intraperitoneally in the animals every other day. The animals are sacrificed and tumors are harvested on day 16. RCM-1 treatment decreases Rd76-9 tumor growth as compared to the DMSO-treated group. Mouse B 16-FlO melanoma cells (1×106 cells) are injected subcutaneously in C56Bl/6J mice (n=7 animals per group). Three days after the tumor cell inoculation, 40 μL of either Vehicle (DMSO) or RCM1 (20 mg/Kg body weight) are injected intraperitoneally in the animals every other day. The animals are sacrificed and tumors are harvested on day 12[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3553 mL | 11.7763 mL | 23.5527 mL | 58.8817 mL |
| 5 mM | 0.4711 mL | 2.3553 mL | 4.7105 mL | 11.7763 mL | |
| 10 mM | 0.2355 mL | 1.1776 mL | 2.3553 mL | 5.8882 mL | |
| 15 mM | 0.1570 mL | 0.7851 mL | 1.5702 mL | 3.9254 mL | |
| 20 mM | 0.1178 mL | 0.5888 mL | 1.1776 mL | 2.9441 mL | |
| 25 mM | 0.0942 mL | 0.4711 mL | 0.9421 mL | 2.3553 mL | |
| 30 mM | 0.0785 mL | 0.3925 mL | 0.7851 mL | 1.9627 mL |
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