Corydamine
Corydamine, 3-arylisoquinoline alkaloid, is a potent DNA topoisomerase I/II inhibitor. Corydamine has anti-cancer activity.
For research use only. We do not sell to patients.
- CAS No.: 49870-84-0
- Formula: C20H18N2O4
- Molecular Weight:350.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Topoisomerase Isoforms
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Biological Activity
|
Topoisomerase I |
Topoisomerase II |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BGC-823 | IC50 |
25.92 μM
Compound: 1
|
Antiproliferative activity against human BGC-823 cells after 72 hrs by MTT assay
Antiproliferative activity against human BGC-823 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| HCCLM9 | IC50 |
10.02 μM
Compound: 1
|
Antiproliferative activity against human HCCLM9 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCCLM9 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| HCT-116 | IC50 |
>150 μM
Compound: 1
|
Antiproliferative activity against human HCT-116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| HepG2 | IC50 |
45 μM
Compound: 1
|
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| HGC-27 | IC50 |
20.91 μM
Compound: 1
|
Antiproliferative activity against human HGC-27 cells after 72 hrs by MTT assay
Antiproliferative activity against human HGC-27 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| HL-60 | IC50 |
112.8 μM
Compound: 1
|
Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay
Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| HT-29 | IC50 |
23 μM
Compound: 1
|
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| Huh-7 | IC50 |
15.51 μM
Compound: 1
|
Antiproliferative activity against human Huh-7 cells after 72 hrs by MTT assay
Antiproliferative activity against human Huh-7 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| L02 | IC50 |
>150 μM
Compound: 1
|
Antiproliferative activity against human L02 cells after 72 hrs by MTT assay
Antiproliferative activity against human L02 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| MCF7 | IC50 |
49.9 μM
Compound: 1
|
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| MDA-MB-231 | IC50 |
19.3 μM
Compound: 1
|
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| RKO | IC50 |
63.5 μM
Compound: 1
|
Antiproliferative activity against human RKO cells after 72 hrs by MTT assay
Antiproliferative activity against human RKO cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| SGC-7901 | IC50 |
10620 μM
Compound: 1
|
Antiproliferative activity against human SGC-7901 cells after 72 hrs by MTT assay
Antiproliferative activity against human SGC-7901 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| SK-HEP1 | IC50 |
28.19 μM
Compound: 1
|
Antiproliferative activity against human SK-HEP1 cells after 72 hrs by MTT assay
Antiproliferative activity against human SK-HEP1 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| SW480 | IC50 |
25.4 μM
Compound: 1
|
Antiproliferative activity against human SW480 cells after 72 hrs by MTT assay
Antiproliferative activity against human SW480 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
| U-251 | IC50 |
19.1 μM
Compound: 1
|
Antiproliferative activity against human U-251 cells after 72 hrs by MTT assay
Antiproliferative activity against human U-251 cells after 72 hrs by MTT assay
|
[PMID: 34802836] |
Chemical Information
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CAS No. 49870-84-0
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Molecular Weight 350.37
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Formula C20H18N2O4
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SMILES
CNCCC1=C(C2=CC3=C(C=N2)C(OCO4)=C4C=C3)C=C(OCO5)C5=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)