IW927
Based on 1 Customer Validation
IW927 is a photochemically enhanced TNF-α-TNFR1 interaction inhibitor that blocks the binding of TNF-α to TNFRc1 with an IC50 value of 50 nM. IW927 binds reversibly to the TNFRc1 with weak affinity (Kd = 40-100 μM), covalently modifies the receptor via a photochemical reaction, and does not bind the related cytokine receptors TNFRc2 or CD40. IW927 disrupts TNFα-induced IκB phosphorylation with an IC50 value of 600 nM. IW927 can be used to develop light-independent inhibitors.
For research use only. We do not sell to patients.
- Purity: 99.23%
- CAS No.: 389142-48-7
- Formula: C22H23N3O3S2
- Molecular Weight:441.57
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IW927 (1 μM in the light or 100 μM in the dark, 5 min) exhibits significant light dependence, forming irreversible covalent binding to TNFRc1 only under light conditions and only reversible binding under light-protected conditions[1].
IW927 (24 h) does not display any cytotoxicity at concentrations as high as 100 μM in Ramos cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 389142-48-7
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Appearance Solid
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Molecular Weight 441.57
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Formula C22H23N3O3S2
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Color Yellow to orange
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SMILES
O=C(C1=CC2=C(C=C(S2)C3=CC=CC(OC)=C3)N1C4=S)N4CCCN5CCOCC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 10 mg/mL (22.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2646 mL | 11.3232 mL | 22.6465 mL | 56.6162 mL |
| 5 mM | 0.4529 mL | 2.2646 mL | 4.5293 mL | 11.3232 mL | |
| 10 mM | 0.2265 mL | 1.1323 mL | 2.2646 mL | 5.6616 mL | |
| 15 mM | 0.1510 mL | 0.7549 mL | 1.5098 mL | 3.7744 mL | |
| 20 mM | 0.1132 mL | 0.5662 mL | 1.1323 mL | 2.8308 mL |
IW927 Related Classifications
HY-118922 Related Classifications
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