Piritrexim
Based on 1 Customer Validation
Piritrexim (BW 301U) is a potent dihydrofolate reductase (DHFR) inhibitor against Pneumocystis carinii and Toxoplasma gondii, with IC50 values of 0.038 and 0.011 μM, respectively. Piritrexim can be used for acquired immune deficiency syndrome (AIDS) research. Piritrexim also is an anticancer agent.
For research use only. We do not sell to patients.
- Purity: 99.07%
- CAS No.: 72732-56-0
- Formula: C17H19N5O2
- Molecular Weight:325.37
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
24 nM
Compound: PTX
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Cytotoxic activity evaluated against A549 tumor cells
Cytotoxic activity evaluated against A549 tumor cells
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[PMID: 8632413] |
| CCRF S-180 | ED50 |
0.012 μM
Compound: BW-301U
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Cytotoxic activity against the S180 cell cultures
Cytotoxic activity against the S180 cell cultures
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[PMID: 6928967] |
| CCRF-CEM | IC50 |
0.013 μM
Compound: 5
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Concentration causing inhibition of CCRF-CEM human leukemic lymphoblasts growth in a 72 hr culture
Concentration causing inhibition of CCRF-CEM human leukemic lymphoblasts growth in a 72 hr culture
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[PMID: 15974594] |
| D54 cell line | IC50 |
230 nM
Compound: PTX
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Cytotoxic Activity was evaluated against D54 tumor cells
Cytotoxic Activity was evaluated against D54 tumor cells
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[PMID: 8632413] |
| Daoy | IC50 |
70 nM
Compound: PTX
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Cytotoxic activity was evaluated against Daoy tumor cells
Cytotoxic activity was evaluated against Daoy tumor cells
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[PMID: 8632413] |
| HCT-8 | IC50 |
68 nM
Compound: PTX
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Cytotoxic Activity was evaluated against HCT-8 tumor cells
Cytotoxic Activity was evaluated against HCT-8 tumor cells
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[PMID: 8632413] |
| L1210 | ED50 |
0.002 μM
Compound: BW-301U
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Cytotoxic activity against the L1210 cell cultures
Cytotoxic activity against the L1210 cell cultures
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[PMID: 6928967] |
| NCI-H460 | IC50 |
260 nM
Compound: PTX
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Cytotoxic Activity was evaluated against H460 tumor cells
Cytotoxic Activity was evaluated against H460 tumor cells
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[PMID: 8632413] |
| P388 | IC50 |
21 nM
Compound: PTX
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Cytotoxic activity was evaluated against P388D1 tumor cells
Cytotoxic activity was evaluated against P388D1 tumor cells
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[PMID: 8632413] |
| U-373MG ATCC | IC50 |
55 nM
Compound: PTX
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Cytotoxic activity was evaluated against U373MG tumor cells
Cytotoxic activity was evaluated against U373MG tumor cells
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[PMID: 8632413] |
| U-87MG ATCC | IC50 |
48 nM
Compound: PTX
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Cytotoxic activity was evaluated against U87MG tumor cells
Cytotoxic activity was evaluated against U87MG tumor cells
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[PMID: 8632413] |
| Vero | IC50 |
30 nM
Compound: PTX
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Cytotoxic Activity was evaluated against Vero tumor cells
Cytotoxic Activity was evaluated against Vero tumor cells
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[PMID: 8632413] |
| W256 | ED50 |
0.008 μM
Compound: BW-301U
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Cytotoxic activity against the Walker 256 carcinosarcoma in rats
Cytotoxic activity against the Walker 256 carcinosarcoma in rats
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[PMID: 6928967] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 72732-56-0
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Appearance Solid
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Molecular Weight 325.37
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Formula C17H19N5O2
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Color Off-white to light yellow
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SMILES
CC1=C(CC2=C(C=CC(OC)=C2)OC)C=NC3=NC(N)=NC(N)=C13
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Synonyms
BW 301U; NSC 351521
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Rosowsky A, et al. 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. J Med Chem. 1993 Oct 15;36(21):3103-12. [Content Brief]
[2]. Zink M, et al. Structural variations of piritrexim, a lipophilic inhibitor of human dihydrofolate reductase: synthesis, antitumor activity and molecular modeling investigations. Eur J Med Chem. 2004 Dec;39(12):1079-88. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Piritrexim Related Classifications
HY-106434 Related Classifications
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